Evaluation of the efficacy of chemotherapy for tubular carcinoma of the breast: A Surveillance, Epidemiology, and End Results cohort study
Abstract Background The use of systematic treatment for tubular carcinoma (TC) of the breast remained controversial. This study aimed to explore the efficacy of chemotherapy on TC to develop individualized treatment strategies. Methods Using the Surveillance, Epidemiology, and End Results (SEER) dat...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-05-01
|
| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.5763 |
| _version_ | 1797817673987391488 |
|---|---|
| author | Yuting Zhao Na Chai Shouyu Li Lutong Yan Can Zhou Jianjun He Huimin Zhang |
| author_facet | Yuting Zhao Na Chai Shouyu Li Lutong Yan Can Zhou Jianjun He Huimin Zhang |
| author_sort | Yuting Zhao |
| collection | DOAJ |
| description | Abstract Background The use of systematic treatment for tubular carcinoma (TC) of the breast remained controversial. This study aimed to explore the efficacy of chemotherapy on TC to develop individualized treatment strategies. Methods Using the Surveillance, Epidemiology, and End Results (SEER) database, 6486 eligible cases with TC and 309,304 with invasive ductal carcinoma (IDC) were collected. Breast cancer‐specific survival (BCSS) was assessed through multivariable Cox analyses and Kaplan–Meier analyses. Differences between groups were balanced using propensity score matching (PSM) and inverse probability of treatment weighting (IPTW). Results Compared with IDC patients, TC patients had a more favorable long‐term BCSS after PSM (hazard ratio = 0.62, p = 0.004) and IPTW (hazard ratio = 0.61, p < 0.001). Chemotherapy was an unfavorable predictor of BCSS for TC (hazard ratio = 3.20, p < 0.001). After stratifying by hormone receptor (HR) and lymph node (LN) status, chemotherapy was correlated with worse BCSS in the HR+/LN− subgroup (hazard ratio = 6.95, p = 0.001) but showed no impact on BCSS in the HR+/LN+ (hazard ratio = 0.75, p = 0.780) and HR−/LN− (hazard ratio = 7.87, p = 0.150) subgroups. Conclusions Tubular carcinoma is a low‐grade malignant tumor with favorable clinicopathological features and excellent long‐term survival. Adjuvant chemotherapy was not recommended for TC regardless of HR and LN status, while the therapy regimens should be carefully individualized. |
| first_indexed | 2024-03-13T08:56:56Z |
| format | Article |
| id | doaj.art-fb74e5dfbb2847fba0a565b9c642b0be |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-03-13T08:56:56Z |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-fb74e5dfbb2847fba0a565b9c642b0be2023-05-28T20:33:59ZengWileyCancer Medicine2045-76342023-05-01129103261033910.1002/cam4.5763Evaluation of the efficacy of chemotherapy for tubular carcinoma of the breast: A Surveillance, Epidemiology, and End Results cohort studyYuting Zhao0Na Chai1Shouyu Li2Lutong Yan3Can Zhou4Jianjun He5Huimin Zhang6Department of Breast Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Breast Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Breast Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Breast Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Breast Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Breast Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Breast Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaAbstract Background The use of systematic treatment for tubular carcinoma (TC) of the breast remained controversial. This study aimed to explore the efficacy of chemotherapy on TC to develop individualized treatment strategies. Methods Using the Surveillance, Epidemiology, and End Results (SEER) database, 6486 eligible cases with TC and 309,304 with invasive ductal carcinoma (IDC) were collected. Breast cancer‐specific survival (BCSS) was assessed through multivariable Cox analyses and Kaplan–Meier analyses. Differences between groups were balanced using propensity score matching (PSM) and inverse probability of treatment weighting (IPTW). Results Compared with IDC patients, TC patients had a more favorable long‐term BCSS after PSM (hazard ratio = 0.62, p = 0.004) and IPTW (hazard ratio = 0.61, p < 0.001). Chemotherapy was an unfavorable predictor of BCSS for TC (hazard ratio = 3.20, p < 0.001). After stratifying by hormone receptor (HR) and lymph node (LN) status, chemotherapy was correlated with worse BCSS in the HR+/LN− subgroup (hazard ratio = 6.95, p = 0.001) but showed no impact on BCSS in the HR+/LN+ (hazard ratio = 0.75, p = 0.780) and HR−/LN− (hazard ratio = 7.87, p = 0.150) subgroups. Conclusions Tubular carcinoma is a low‐grade malignant tumor with favorable clinicopathological features and excellent long‐term survival. Adjuvant chemotherapy was not recommended for TC regardless of HR and LN status, while the therapy regimens should be carefully individualized.https://doi.org/10.1002/cam4.5763breast cancer‐specific survivalchemotherapypropensity score matchingSEERtubular carcinoma |
| spellingShingle | Yuting Zhao Na Chai Shouyu Li Lutong Yan Can Zhou Jianjun He Huimin Zhang Evaluation of the efficacy of chemotherapy for tubular carcinoma of the breast: A Surveillance, Epidemiology, and End Results cohort study Cancer Medicine breast cancer‐specific survival chemotherapy propensity score matching SEER tubular carcinoma |
| title | Evaluation of the efficacy of chemotherapy for tubular carcinoma of the breast: A Surveillance, Epidemiology, and End Results cohort study |
| title_full | Evaluation of the efficacy of chemotherapy for tubular carcinoma of the breast: A Surveillance, Epidemiology, and End Results cohort study |
| title_fullStr | Evaluation of the efficacy of chemotherapy for tubular carcinoma of the breast: A Surveillance, Epidemiology, and End Results cohort study |
| title_full_unstemmed | Evaluation of the efficacy of chemotherapy for tubular carcinoma of the breast: A Surveillance, Epidemiology, and End Results cohort study |
| title_short | Evaluation of the efficacy of chemotherapy for tubular carcinoma of the breast: A Surveillance, Epidemiology, and End Results cohort study |
| title_sort | evaluation of the efficacy of chemotherapy for tubular carcinoma of the breast a surveillance epidemiology and end results cohort study |
| topic | breast cancer‐specific survival chemotherapy propensity score matching SEER tubular carcinoma |
| url | https://doi.org/10.1002/cam4.5763 |
| work_keys_str_mv | AT yutingzhao evaluationoftheefficacyofchemotherapyfortubularcarcinomaofthebreastasurveillanceepidemiologyandendresultscohortstudy AT nachai evaluationoftheefficacyofchemotherapyfortubularcarcinomaofthebreastasurveillanceepidemiologyandendresultscohortstudy AT shouyuli evaluationoftheefficacyofchemotherapyfortubularcarcinomaofthebreastasurveillanceepidemiologyandendresultscohortstudy AT lutongyan evaluationoftheefficacyofchemotherapyfortubularcarcinomaofthebreastasurveillanceepidemiologyandendresultscohortstudy AT canzhou evaluationoftheefficacyofchemotherapyfortubularcarcinomaofthebreastasurveillanceepidemiologyandendresultscohortstudy AT jianjunhe evaluationoftheefficacyofchemotherapyfortubularcarcinomaofthebreastasurveillanceepidemiologyandendresultscohortstudy AT huiminzhang evaluationoftheefficacyofchemotherapyfortubularcarcinomaofthebreastasurveillanceepidemiologyandendresultscohortstudy |