An unusual outcome of papillary renal cell carcinoma with lung metastases: a case report and review of literature
Abstract Background Renal cell carcinoma (RCC) is a heterogeneous group of malignant epithelial tumors of the kidney. It accounts for more than 90% of all kidney cancers. However, papillary RCC is the second most common histologic subtype representing 10–15% of all RCCs. The mean age of presentation...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-01-01
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| Series: | African Journal of Urology |
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| Online Access: | https://doi.org/10.1186/s12301-020-00103-z |
| _version_ | 1818562578097373184 |
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| author | Emmanuel Owusu Ofori Baba Alhaji Bin Alhassan Edwina Ayaaba Ayabilah Patrick Opoku Manu Maison Alvin Asante-Asamani Henry Atawura Ganiyu Adebisi Rahman Patrick Kafui Akakpo Emmanuel Gustav Imbeah Prince Wilson Ofori |
| author_facet | Emmanuel Owusu Ofori Baba Alhaji Bin Alhassan Edwina Ayaaba Ayabilah Patrick Opoku Manu Maison Alvin Asante-Asamani Henry Atawura Ganiyu Adebisi Rahman Patrick Kafui Akakpo Emmanuel Gustav Imbeah Prince Wilson Ofori |
| author_sort | Emmanuel Owusu Ofori |
| collection | DOAJ |
| description | Abstract Background Renal cell carcinoma (RCC) is a heterogeneous group of malignant epithelial tumors of the kidney. It accounts for more than 90% of all kidney cancers. However, papillary RCC is the second most common histologic subtype representing 10–15% of all RCCs. The mean age of presentation for papillary RCC ranges between 59 and 63 years but more importantly when RCC is diagnosed at a younger age, the possibility of an underlying hereditary kidney cancer syndrome should be considered. RCC potentially metastasizes to many different organs with lung being the commonest site accounting for 45.2%. The treatment for metastatic RCC is mostly multimodal for most patients. However, patients with untreated pulmonary metastases have been observed to have very poor prognosis with a 5-year overall survival rate of only 5% or even less and thus the need to report on the unusual outcome of our patient who had a metastatic disease. Case presentation The present study reports a papillary renal cell carcinoma with multiple lung metastases in a 31-year-old woman who presented with progressive right flank mass and pain with no chest symptoms. She underwent cytoreductive radical nephrectomy via a right subcostal incision. Patient, however, did not undergo metastasectomy nor palliative systemic therapy and was seen 5 years post-nephrectomy. Conclusion Our patient with metastatic RCC, without undergoing metastasectomy nor palliative systemic therapy, remained stable with 5-year progression-free survival post-cytoreductive nephrectomy. |
| first_indexed | 2024-12-14T01:05:35Z |
| format | Article |
| id | doaj.art-fb788d0383d64e7fbc0c6e1e43459ad7 |
| institution | Directory Open Access Journal |
| issn | 1110-5704 1961-9987 |
| language | English |
| last_indexed | 2024-12-14T01:05:35Z |
| publishDate | 2021-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | African Journal of Urology |
| spelling | doaj.art-fb788d0383d64e7fbc0c6e1e43459ad72022-12-21T23:22:59ZengSpringerOpenAfrican Journal of Urology1110-57041961-99872021-01-0127111010.1186/s12301-020-00103-zAn unusual outcome of papillary renal cell carcinoma with lung metastases: a case report and review of literatureEmmanuel Owusu Ofori0Baba Alhaji Bin Alhassan1Edwina Ayaaba Ayabilah2Patrick Opoku Manu Maison3Alvin Asante-Asamani4Henry Atawura5Ganiyu Adebisi Rahman6Patrick Kafui Akakpo7Emmanuel Gustav Imbeah8Prince Wilson Ofori9Department of Surgery, Cape Coast Teaching HospitalDepartment of Surgery, Cape Coast Teaching HospitalDepartment of Surgery, Cape Coast Teaching HospitalDepartment of Surgery, School of Medical Sciences, College of Health Sciences, University of Cape CoastDepartment of Surgery, Cape Coast Teaching HospitalDepartment of Surgery, School of Medical Sciences, College of Health Sciences, University of Cape CoastDepartment of Surgery, School of Medical Sciences, College of Health Sciences, University of Cape CoastDepartment of Pathology, School of Medical Sciences, College of Health Sciences, University of Cape CoastDepartment of Pathology, School of Medical Sciences, College of Health Sciences, University of Cape CoastCape Coast Teaching HospitalAbstract Background Renal cell carcinoma (RCC) is a heterogeneous group of malignant epithelial tumors of the kidney. It accounts for more than 90% of all kidney cancers. However, papillary RCC is the second most common histologic subtype representing 10–15% of all RCCs. The mean age of presentation for papillary RCC ranges between 59 and 63 years but more importantly when RCC is diagnosed at a younger age, the possibility of an underlying hereditary kidney cancer syndrome should be considered. RCC potentially metastasizes to many different organs with lung being the commonest site accounting for 45.2%. The treatment for metastatic RCC is mostly multimodal for most patients. However, patients with untreated pulmonary metastases have been observed to have very poor prognosis with a 5-year overall survival rate of only 5% or even less and thus the need to report on the unusual outcome of our patient who had a metastatic disease. Case presentation The present study reports a papillary renal cell carcinoma with multiple lung metastases in a 31-year-old woman who presented with progressive right flank mass and pain with no chest symptoms. She underwent cytoreductive radical nephrectomy via a right subcostal incision. Patient, however, did not undergo metastasectomy nor palliative systemic therapy and was seen 5 years post-nephrectomy. Conclusion Our patient with metastatic RCC, without undergoing metastasectomy nor palliative systemic therapy, remained stable with 5-year progression-free survival post-cytoreductive nephrectomy.https://doi.org/10.1186/s12301-020-00103-zRenal cell carcinomaPapillary RCCLung metastasisTumorNephrectomy |
| spellingShingle | Emmanuel Owusu Ofori Baba Alhaji Bin Alhassan Edwina Ayaaba Ayabilah Patrick Opoku Manu Maison Alvin Asante-Asamani Henry Atawura Ganiyu Adebisi Rahman Patrick Kafui Akakpo Emmanuel Gustav Imbeah Prince Wilson Ofori An unusual outcome of papillary renal cell carcinoma with lung metastases: a case report and review of literature African Journal of Urology Renal cell carcinoma Papillary RCC Lung metastasis Tumor Nephrectomy |
| title | An unusual outcome of papillary renal cell carcinoma with lung metastases: a case report and review of literature |
| title_full | An unusual outcome of papillary renal cell carcinoma with lung metastases: a case report and review of literature |
| title_fullStr | An unusual outcome of papillary renal cell carcinoma with lung metastases: a case report and review of literature |
| title_full_unstemmed | An unusual outcome of papillary renal cell carcinoma with lung metastases: a case report and review of literature |
| title_short | An unusual outcome of papillary renal cell carcinoma with lung metastases: a case report and review of literature |
| title_sort | unusual outcome of papillary renal cell carcinoma with lung metastases a case report and review of literature |
| topic | Renal cell carcinoma Papillary RCC Lung metastasis Tumor Nephrectomy |
| url | https://doi.org/10.1186/s12301-020-00103-z |
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