Antileishmanial and trypanocidal activity of Brazilian Cerrado plants
The side effects and the emerging resistance to the available drugs against leishmaniasis and trypanosomiasis led to the urgent need for new therapeutic agents against these diseases. Thirty one extracts of thirteen medicinal plants from the Brazilian Cerrado were therefore evaluated in vitro for th...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2005-11-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000700019 |
| _version_ | 1797703149146865664 |
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| author | Mariana Laundry de Mesquita Julie Desrivot Bories Alain Fournet José Elias de Paula Philippe Grellier Laila Salmen Espindola |
| author_facet | Mariana Laundry de Mesquita Julie Desrivot Bories Alain Fournet José Elias de Paula Philippe Grellier Laila Salmen Espindola |
| author_sort | Mariana Laundry de Mesquita |
| collection | DOAJ |
| description | The side effects and the emerging resistance to the available drugs against leishmaniasis and trypanosomiasis led to the urgent need for new therapeutic agents against these diseases. Thirty one extracts of thirteen medicinal plants from the Brazilian Cerrado were therefore evaluated in vitro for their antiprotozoal activity against promastigotes of Leishmania donovani, and amastigotes of Trypanosoma cruzi. Among the selected plants, Casearia sylvestris var. lingua was the most active against both L. donovani and T. cruzi. Fifteen extracts were active against promastigotes of L. donovani with concentrations inhibiting 50% of parasite growth (IC50) between 0.1-10 µg/ml, particularly those of Annona crassiflora (Annonaceae), Himatanthus obovatus (Apocynaceae), Guarea kunthiana (Meliaceae), Cupania vernalis (Sapindaceae), and Serjania lethalis (Sapindaceae). With regard to amastigotes of T. cruzi, extracts of A. crassiflora, Duguetia furfuracea (Annonaceae), and C. sylvestris var. lingua were active with IC50 values between 0.3-10 µg/ml. Bioassay fractionations of the more active extracts are under progress to identify the active antiparasite compounds. |
| first_indexed | 2024-03-12T05:01:21Z |
| format | Article |
| id | doaj.art-fb7a9c3c8db24c9c9712694e981f1078 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T05:01:21Z |
| publishDate | 2005-11-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-fb7a9c3c8db24c9c9712694e981f10782023-09-03T09:12:01ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602005-11-01100778378710.1590/S0074-02762005000700019Antileishmanial and trypanocidal activity of Brazilian Cerrado plantsMariana Laundry de MesquitaJulie DesrivotBoriesAlain FournetJosé Elias de PaulaPhilippe GrellierLaila Salmen EspindolaThe side effects and the emerging resistance to the available drugs against leishmaniasis and trypanosomiasis led to the urgent need for new therapeutic agents against these diseases. Thirty one extracts of thirteen medicinal plants from the Brazilian Cerrado were therefore evaluated in vitro for their antiprotozoal activity against promastigotes of Leishmania donovani, and amastigotes of Trypanosoma cruzi. Among the selected plants, Casearia sylvestris var. lingua was the most active against both L. donovani and T. cruzi. Fifteen extracts were active against promastigotes of L. donovani with concentrations inhibiting 50% of parasite growth (IC50) between 0.1-10 µg/ml, particularly those of Annona crassiflora (Annonaceae), Himatanthus obovatus (Apocynaceae), Guarea kunthiana (Meliaceae), Cupania vernalis (Sapindaceae), and Serjania lethalis (Sapindaceae). With regard to amastigotes of T. cruzi, extracts of A. crassiflora, Duguetia furfuracea (Annonaceae), and C. sylvestris var. lingua were active with IC50 values between 0.3-10 µg/ml. Bioassay fractionations of the more active extracts are under progress to identify the active antiparasite compounds.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000700019Brazilian Cerrado plantsleishmaniasisChagas diseaseLeishmania donovaniTrypanosoma cruziBrazil |
| spellingShingle | Mariana Laundry de Mesquita Julie Desrivot Bories Alain Fournet José Elias de Paula Philippe Grellier Laila Salmen Espindola Antileishmanial and trypanocidal activity of Brazilian Cerrado plants Memorias do Instituto Oswaldo Cruz Brazilian Cerrado plants leishmaniasis Chagas disease Leishmania donovani Trypanosoma cruzi Brazil |
| title | Antileishmanial and trypanocidal activity of Brazilian Cerrado plants |
| title_full | Antileishmanial and trypanocidal activity of Brazilian Cerrado plants |
| title_fullStr | Antileishmanial and trypanocidal activity of Brazilian Cerrado plants |
| title_full_unstemmed | Antileishmanial and trypanocidal activity of Brazilian Cerrado plants |
| title_short | Antileishmanial and trypanocidal activity of Brazilian Cerrado plants |
| title_sort | antileishmanial and trypanocidal activity of brazilian cerrado plants |
| topic | Brazilian Cerrado plants leishmaniasis Chagas disease Leishmania donovani Trypanosoma cruzi Brazil |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000700019 |
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