Setting a stage: Inflammation during preeclampsia and postpartum
Preeclampsia (PE) is a leading cause of maternal and fetal mortality worldwide. The immune system plays a critical role in normal pregnancy progression; however, inappropriate inflammatory responses have been consistently linked with PE pathophysiology. This inflammatory phenotype consists of activa...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1130116/full |
| _version_ | 1797897197492109312 |
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| author | Owen Herrock Evangeline Deer Babbette LaMarca Babbette LaMarca |
| author_facet | Owen Herrock Evangeline Deer Babbette LaMarca Babbette LaMarca |
| author_sort | Owen Herrock |
| collection | DOAJ |
| description | Preeclampsia (PE) is a leading cause of maternal and fetal mortality worldwide. The immune system plays a critical role in normal pregnancy progression; however, inappropriate inflammatory responses have been consistently linked with PE pathophysiology. This inflammatory phenotype consists of activation of the innate immune system, adaptive immune system, and increased inflammatory mediators in circulation. Moreover, recent studies have shown that the inflammatory profile seen in PE persists into the postpartum period. This manuscript aims to highlight recent advances in research relating to inflammation in PE as well as the inflammation that persists postpartum in women after a PE pregnancy. With the advent of the COVID-19 pandemic, there has been an increase in obstetric disorders associated with COVID-19 infection during pregnancy. This manuscript also aims to shed light on the relationship between COVID-19 infection during pregnancy and the increased incidence of PE in these women. |
| first_indexed | 2024-04-10T07:53:44Z |
| format | Article |
| id | doaj.art-fb7bac62904b483ea8784d19ecab91aa |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-10T07:53:44Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-fb7bac62904b483ea8784d19ecab91aa2023-02-23T07:12:16ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-02-011410.3389/fphys.2023.11301161130116Setting a stage: Inflammation during preeclampsia and postpartumOwen Herrock0Evangeline Deer1Babbette LaMarca2Babbette LaMarca3Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, United StatesDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, United StatesDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, United StatesDepartment of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS, United StatesPreeclampsia (PE) is a leading cause of maternal and fetal mortality worldwide. The immune system plays a critical role in normal pregnancy progression; however, inappropriate inflammatory responses have been consistently linked with PE pathophysiology. This inflammatory phenotype consists of activation of the innate immune system, adaptive immune system, and increased inflammatory mediators in circulation. Moreover, recent studies have shown that the inflammatory profile seen in PE persists into the postpartum period. This manuscript aims to highlight recent advances in research relating to inflammation in PE as well as the inflammation that persists postpartum in women after a PE pregnancy. With the advent of the COVID-19 pandemic, there has been an increase in obstetric disorders associated with COVID-19 infection during pregnancy. This manuscript also aims to shed light on the relationship between COVID-19 infection during pregnancy and the increased incidence of PE in these women.https://www.frontiersin.org/articles/10.3389/fphys.2023.1130116/fullpreecclampsiaimmune cellschronic inflammationpregnancypostpartum |
| spellingShingle | Owen Herrock Evangeline Deer Babbette LaMarca Babbette LaMarca Setting a stage: Inflammation during preeclampsia and postpartum Frontiers in Physiology preecclampsia immune cells chronic inflammation pregnancy postpartum |
| title | Setting a stage: Inflammation during preeclampsia and postpartum |
| title_full | Setting a stage: Inflammation during preeclampsia and postpartum |
| title_fullStr | Setting a stage: Inflammation during preeclampsia and postpartum |
| title_full_unstemmed | Setting a stage: Inflammation during preeclampsia and postpartum |
| title_short | Setting a stage: Inflammation during preeclampsia and postpartum |
| title_sort | setting a stage inflammation during preeclampsia and postpartum |
| topic | preecclampsia immune cells chronic inflammation pregnancy postpartum |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1130116/full |
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