Overrunning in clinical trials: some thoughts from a methodological review

Overrunning in clinical trials: some thoughts from a methodological review

Abstract Background In sequential and adaptive trials, the delay that happens after the trial is stopped, by a predetermined stopping criterion, takes the name of overrunning. Overrunning consists of extra data, collected by investigators while awaiting results of the interim analysis (IA). The incl...

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Bibliographic Details
Main Authors: Ileana Baldi, Danila Azzolina, Nicola Soriani, Beatrice Barbetta, Paola Vaghi, Giampaolo Giacovelli, Paola Berchialla, Dario Gregori
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Trials
Subjects:
Overrunning
Deletion method
Combining p values
Repeated confidence interval
Online Access:http://link.springer.com/article/10.1186/s13063-020-04526-5

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