Sympatho-Vagal Dysfunction in Systemic Sclerosis: A Follow-Up Study
Systemic sclerosis (SSc) patients often present cardiovascular autonomic dysfunction, which is associated with the risk of arrhythmic complications and mortality. However, little is known regarding the progression of cardiac autonomic impairment over time. We aimed to evaluate the cardiac autonomic...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/1/34 |
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| author | Gabriel Dias Rodrigues Angelica Carandina Costanza Scatà Chiara Bellocchi Lorenzo Beretta Pedro Paulo da Silva Soares Eleonora Tobaldini Nicola Montano |
| author_facet | Gabriel Dias Rodrigues Angelica Carandina Costanza Scatà Chiara Bellocchi Lorenzo Beretta Pedro Paulo da Silva Soares Eleonora Tobaldini Nicola Montano |
| author_sort | Gabriel Dias Rodrigues |
| collection | DOAJ |
| description | Systemic sclerosis (SSc) patients often present cardiovascular autonomic dysfunction, which is associated with the risk of arrhythmic complications and mortality. However, little is known regarding the progression of cardiac autonomic impairment over time. We aimed to evaluate the cardiac autonomic modulation among SSc with limited cutaneous (lcSSc), diffuse cutaneous (dcSSc) subset, and age-matched healthy control (HC) at baseline (t0) and five-year follow-up (t1). In this follow-up study, ECG was recorded at t0 and t1 in twenty-four SSc patients (dcSSc; <i>n</i> = 11 and lcSSc; <i>n</i> = 13) and 11 HC. The heart rate variability (HRV) analysis was conducted. The spectral analysis identified two oscillatory components, low frequency (LF) and high frequency (HF), and the sympatho-vagal balance was assessed by the LF/HF ratio. The LF/HF increased (<i>p</i> = 0.03), and HF reduced at t1 compared to t0 in dcSSc (<i>p</i> = 0.03), which did not occur in the lcSSc and HC groups. Otherwise, both lcSSc and dcSSc groups presented augmented LF/HF at t0 and t1 compared to HC (<i>p</i> < 0.01). In conclusion, a worsening of cardiac autonomic dysfunction is related to the dcSSc subset, in which a more extent of skin fibrosis and internal organs fibrosis is present. |
| first_indexed | 2024-03-09T11:58:06Z |
| format | Article |
| id | doaj.art-fb7e217fb25945f48ef0ad620328c386 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T11:58:06Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-fb7e217fb25945f48ef0ad620328c3862023-11-30T23:07:03ZengMDPI AGLife2075-17292022-12-011313410.3390/life13010034Sympatho-Vagal Dysfunction in Systemic Sclerosis: A Follow-Up StudyGabriel Dias Rodrigues0Angelica Carandina1Costanza Scatà2Chiara Bellocchi3Lorenzo Beretta4Pedro Paulo da Silva Soares5Eleonora Tobaldini6Nicola Montano7Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, ItalyDepartment of Clinical Sciences and Community Health, University of Milan, 20122 Milan, ItalyDepartment of Internal Medicine, Fondazione IRCC.S. Ca’ Granda, Ospedale Maggiore Policlinico, 20122 Milan, ItalyDepartment of Clinical Sciences and Community Health, University of Milan, 20122 Milan, ItalyDepartment of Internal Medicine, Fondazione IRCC.S. Ca’ Granda, Ospedale Maggiore Policlinico, 20122 Milan, ItalyPost-Graduation Program in Cardiovascular Sciences, Fluminense Federal University, Niterói 24020-141, BrazilDepartment of Clinical Sciences and Community Health, University of Milan, 20122 Milan, ItalyDepartment of Clinical Sciences and Community Health, University of Milan, 20122 Milan, ItalySystemic sclerosis (SSc) patients often present cardiovascular autonomic dysfunction, which is associated with the risk of arrhythmic complications and mortality. However, little is known regarding the progression of cardiac autonomic impairment over time. We aimed to evaluate the cardiac autonomic modulation among SSc with limited cutaneous (lcSSc), diffuse cutaneous (dcSSc) subset, and age-matched healthy control (HC) at baseline (t0) and five-year follow-up (t1). In this follow-up study, ECG was recorded at t0 and t1 in twenty-four SSc patients (dcSSc; <i>n</i> = 11 and lcSSc; <i>n</i> = 13) and 11 HC. The heart rate variability (HRV) analysis was conducted. The spectral analysis identified two oscillatory components, low frequency (LF) and high frequency (HF), and the sympatho-vagal balance was assessed by the LF/HF ratio. The LF/HF increased (<i>p</i> = 0.03), and HF reduced at t1 compared to t0 in dcSSc (<i>p</i> = 0.03), which did not occur in the lcSSc and HC groups. Otherwise, both lcSSc and dcSSc groups presented augmented LF/HF at t0 and t1 compared to HC (<i>p</i> < 0.01). In conclusion, a worsening of cardiac autonomic dysfunction is related to the dcSSc subset, in which a more extent of skin fibrosis and internal organs fibrosis is present.https://www.mdpi.com/2075-1729/13/1/34heart rate variabilitysclerodermaautoimmune diseasesautonomic nervous system |
| spellingShingle | Gabriel Dias Rodrigues Angelica Carandina Costanza Scatà Chiara Bellocchi Lorenzo Beretta Pedro Paulo da Silva Soares Eleonora Tobaldini Nicola Montano Sympatho-Vagal Dysfunction in Systemic Sclerosis: A Follow-Up Study Life heart rate variability scleroderma autoimmune diseases autonomic nervous system |
| title | Sympatho-Vagal Dysfunction in Systemic Sclerosis: A Follow-Up Study |
| title_full | Sympatho-Vagal Dysfunction in Systemic Sclerosis: A Follow-Up Study |
| title_fullStr | Sympatho-Vagal Dysfunction in Systemic Sclerosis: A Follow-Up Study |
| title_full_unstemmed | Sympatho-Vagal Dysfunction in Systemic Sclerosis: A Follow-Up Study |
| title_short | Sympatho-Vagal Dysfunction in Systemic Sclerosis: A Follow-Up Study |
| title_sort | sympatho vagal dysfunction in systemic sclerosis a follow up study |
| topic | heart rate variability scleroderma autoimmune diseases autonomic nervous system |
| url | https://www.mdpi.com/2075-1729/13/1/34 |
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