Application of the Mannich reaction in the structural modification of natural products
AbstractThe Mannich reaction is commonly used to introduce N atoms into compound molecules and is thus widely applied in drug synthesis. The Mannich reaction accounts for a certain proportion of structural modifications of natural products. The introduction of Mannich bases can significantly improve...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/14756366.2023.2235095 |
| _version_ | 1797400981684617216 |
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| author | Miao-Xia Pu Hong-Yan Guo Zhe-Shan Quan Xiaoting Li Qing-Kun Shen |
| author_facet | Miao-Xia Pu Hong-Yan Guo Zhe-Shan Quan Xiaoting Li Qing-Kun Shen |
| author_sort | Miao-Xia Pu |
| collection | DOAJ |
| description | AbstractThe Mannich reaction is commonly used to introduce N atoms into compound molecules and is thus widely applied in drug synthesis. The Mannich reaction accounts for a certain proportion of structural modifications of natural products. The introduction of Mannich bases can significantly improve the activity, hydrophilicity, and medicinal properties of compounds; therefore, the Mannich reaction is widely used for the structural modification of natural products. In this paper, the application of the Mannich reaction to the structural modification of natural products is reviewed, providing a method for the structural modification of natural products. |
| first_indexed | 2024-03-09T02:03:19Z |
| format | Article |
| id | doaj.art-fb7ef63896b44eb5a1e2187e38dd8961 |
| institution | Directory Open Access Journal |
| issn | 1475-6366 1475-6374 |
| language | English |
| last_indexed | 2024-03-09T02:03:19Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Enzyme Inhibition and Medicinal Chemistry |
| spelling | doaj.art-fb7ef63896b44eb5a1e2187e38dd89612023-12-08T03:24:20ZengTaylor & Francis GroupJournal of Enzyme Inhibition and Medicinal Chemistry1475-63661475-63742023-12-0138110.1080/14756366.2023.2235095Application of the Mannich reaction in the structural modification of natural productsMiao-Xia Pu0Hong-Yan Guo1Zhe-Shan Quan2Xiaoting Li3Qing-Kun Shen4Interdisciplinary Program of Biological Functional Molecules, College of Integration Science, Yanbian University, Yanji, ChinaKey Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, ChinaKey Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, ChinaKey Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, ChinaKey Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, ChinaAbstractThe Mannich reaction is commonly used to introduce N atoms into compound molecules and is thus widely applied in drug synthesis. The Mannich reaction accounts for a certain proportion of structural modifications of natural products. The introduction of Mannich bases can significantly improve the activity, hydrophilicity, and medicinal properties of compounds; therefore, the Mannich reaction is widely used for the structural modification of natural products. In this paper, the application of the Mannich reaction to the structural modification of natural products is reviewed, providing a method for the structural modification of natural products.https://www.tandfonline.com/doi/10.1080/14756366.2023.2235095Natural productsMannich reactionbiological activity |
| spellingShingle | Miao-Xia Pu Hong-Yan Guo Zhe-Shan Quan Xiaoting Li Qing-Kun Shen Application of the Mannich reaction in the structural modification of natural products Journal of Enzyme Inhibition and Medicinal Chemistry Natural products Mannich reaction biological activity |
| title | Application of the Mannich reaction in the structural modification of natural products |
| title_full | Application of the Mannich reaction in the structural modification of natural products |
| title_fullStr | Application of the Mannich reaction in the structural modification of natural products |
| title_full_unstemmed | Application of the Mannich reaction in the structural modification of natural products |
| title_short | Application of the Mannich reaction in the structural modification of natural products |
| title_sort | application of the mannich reaction in the structural modification of natural products |
| topic | Natural products Mannich reaction biological activity |
| url | https://www.tandfonline.com/doi/10.1080/14756366.2023.2235095 |
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