Usage of Inhalative Sedative for Sedation and Treatment of Patient with Severe Brain Injury in Germany, a Nationwide Survey
Brain injured patients often need deep sedation to prevent or treat increased intracranial pressure. The mainly used IV sedatives have side effects and/or high context-sensitive half-lives, limiting their use. Inhalative sedatives have comparatively minor side effects and a brief context-sensitive h...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/19/6401 |
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| author | Svea Roxana Roggenbuck André Worm Martin Juenemann Christian Claudi Omar Alhaj Omar Marlene Tschernatsch Hagen B. Huttner Patrick Schramm |
| author_facet | Svea Roxana Roggenbuck André Worm Martin Juenemann Christian Claudi Omar Alhaj Omar Marlene Tschernatsch Hagen B. Huttner Patrick Schramm |
| author_sort | Svea Roxana Roggenbuck |
| collection | DOAJ |
| description | Brain injured patients often need deep sedation to prevent or treat increased intracranial pressure. The mainly used IV sedatives have side effects and/or high context-sensitive half-lives, limiting their use. Inhalative sedatives have comparatively minor side effects and a brief context-sensitive half-life. Despite the theoretical advantages, evidence in this patient group is lacking. A Germany-wide survey with 21 questions was conducted to find out how widespread the use of inhaled sedation is. An invitation for the survey was sent to 226 leaders of intensive care units (ICU) treating patients with brain injury as listed by the German Society for Neurointensive Care. Eighty-nine participants answered the questionnaire, but not all items were responded to, which resulted in different absolute counts. Most of them (88%) were university or high-level hospital ICU leaders and (67%) were leaders of specialized neuro-ICUs. Of these, 53/81 (65%) use inhalative sedation, and of the remaining 28, 17 reported interest in using this kind of sedation. Isoflurane is used by 43/53 (81%), sevoflurane by 15/53 (28%), and desflurane by 2. Hypotension and mydriasis are the most common reported side effects (25%). The presented survey showed that inhalative sedatives were used in a significant number of intensive care units in Germany to treat severely brain-injured patients. |
| first_indexed | 2024-03-10T21:42:19Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T21:42:19Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-fb7f15eb2f4443f890bb004c4111a7212023-11-19T14:38:15ZengMDPI AGJournal of Clinical Medicine2077-03832023-10-011219640110.3390/jcm12196401Usage of Inhalative Sedative for Sedation and Treatment of Patient with Severe Brain Injury in Germany, a Nationwide SurveySvea Roxana Roggenbuck0André Worm1Martin Juenemann2Christian Claudi3Omar Alhaj Omar4Marlene Tschernatsch5Hagen B. Huttner6Patrick Schramm7Department of Neurology, University Hospital of the Justus-Liebig-University Giessen, Klinikstrasse 33, 35392 Giessen, GermanyDepartment of Neurology, University Hospital of the Justus-Liebig-University Giessen, Klinikstrasse 33, 35392 Giessen, GermanyDepartment of Neurology, University Hospital of the Justus-Liebig-University Giessen, Klinikstrasse 33, 35392 Giessen, GermanyDepartment of Neurology, University Hospital of the Justus-Liebig-University Giessen, Klinikstrasse 33, 35392 Giessen, GermanyDepartment of Neurology, University Hospital of the Justus-Liebig-University Giessen, Klinikstrasse 33, 35392 Giessen, GermanyDepartment of Neurology, University Hospital of the Justus-Liebig-University Giessen, Klinikstrasse 33, 35392 Giessen, GermanyDepartment of Neurology, University Hospital of the Justus-Liebig-University Giessen, Klinikstrasse 33, 35392 Giessen, GermanyDepartment of Neurology, University Hospital of the Justus-Liebig-University Giessen, Klinikstrasse 33, 35392 Giessen, GermanyBrain injured patients often need deep sedation to prevent or treat increased intracranial pressure. The mainly used IV sedatives have side effects and/or high context-sensitive half-lives, limiting their use. Inhalative sedatives have comparatively minor side effects and a brief context-sensitive half-life. Despite the theoretical advantages, evidence in this patient group is lacking. A Germany-wide survey with 21 questions was conducted to find out how widespread the use of inhaled sedation is. An invitation for the survey was sent to 226 leaders of intensive care units (ICU) treating patients with brain injury as listed by the German Society for Neurointensive Care. Eighty-nine participants answered the questionnaire, but not all items were responded to, which resulted in different absolute counts. Most of them (88%) were university or high-level hospital ICU leaders and (67%) were leaders of specialized neuro-ICUs. Of these, 53/81 (65%) use inhalative sedation, and of the remaining 28, 17 reported interest in using this kind of sedation. Isoflurane is used by 43/53 (81%), sevoflurane by 15/53 (28%), and desflurane by 2. Hypotension and mydriasis are the most common reported side effects (25%). The presented survey showed that inhalative sedatives were used in a significant number of intensive care units in Germany to treat severely brain-injured patients.https://www.mdpi.com/2077-0383/12/19/6401surveys and questionnairescritical careinhalative anestheticsinhalative sedationisofluranesevoflurane |
| spellingShingle | Svea Roxana Roggenbuck André Worm Martin Juenemann Christian Claudi Omar Alhaj Omar Marlene Tschernatsch Hagen B. Huttner Patrick Schramm Usage of Inhalative Sedative for Sedation and Treatment of Patient with Severe Brain Injury in Germany, a Nationwide Survey Journal of Clinical Medicine surveys and questionnaires critical care inhalative anesthetics inhalative sedation isoflurane sevoflurane |
| title | Usage of Inhalative Sedative for Sedation and Treatment of Patient with Severe Brain Injury in Germany, a Nationwide Survey |
| title_full | Usage of Inhalative Sedative for Sedation and Treatment of Patient with Severe Brain Injury in Germany, a Nationwide Survey |
| title_fullStr | Usage of Inhalative Sedative for Sedation and Treatment of Patient with Severe Brain Injury in Germany, a Nationwide Survey |
| title_full_unstemmed | Usage of Inhalative Sedative for Sedation and Treatment of Patient with Severe Brain Injury in Germany, a Nationwide Survey |
| title_short | Usage of Inhalative Sedative for Sedation and Treatment of Patient with Severe Brain Injury in Germany, a Nationwide Survey |
| title_sort | usage of inhalative sedative for sedation and treatment of patient with severe brain injury in germany a nationwide survey |
| topic | surveys and questionnaires critical care inhalative anesthetics inhalative sedation isoflurane sevoflurane |
| url | https://www.mdpi.com/2077-0383/12/19/6401 |
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