Effects of medication intake on the risk of hemorrhage in patients with sporadic cerebral cavernous malformations
ObjectiveRecurrent intracerebral hemorrhage (ICH) poses a high risk for patients with cerebral cavernous malformations (CCMs). This study aimed to assess the influence of medication intake on hemorrhage risk in sporadic CCMs.MethodsFrom a database of 1,409 consecutive patients with CCM (2003–2021),...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.1010170/full |
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| author | Bixia Chen Kirstin Lahl Dino Saban Annika Lenkeit Laurèl Rauschenbach Alejandro N. Santos Yan Li Boerge Schmidt Yuan Zhu Ramazan Jabbarli Karsten H. Wrede Christoph Kleinschnitz Ulrich Sure Philipp Dammann |
| author_facet | Bixia Chen Kirstin Lahl Dino Saban Annika Lenkeit Laurèl Rauschenbach Alejandro N. Santos Yan Li Boerge Schmidt Yuan Zhu Ramazan Jabbarli Karsten H. Wrede Christoph Kleinschnitz Ulrich Sure Philipp Dammann |
| author_sort | Bixia Chen |
| collection | DOAJ |
| description | ObjectiveRecurrent intracerebral hemorrhage (ICH) poses a high risk for patients with cerebral cavernous malformations (CCMs). This study aimed to assess the influence of medication intake on hemorrhage risk in sporadic CCMs.MethodsFrom a database of 1,409 consecutive patients with CCM (2003–2021), subjects with sporadic CCMs and complete magnetic resonance imaging data were included. We evaluated the presence of ICH as a mode of presentation, the occurrence of ICH during follow-up, and medication intake, including beta blockers, statins, antithrombotic therapy, and thyroid hormones. The impact of medication intake on ICH at presentation was calculated using univariate and multivariate logistic regression with age and sex adjustment. The longitudinal cumulative 5-year risk for (re-)hemorrhage was analyzed using the Kaplan–Meier curves and the Cox regression analysis.ResultsA total of 1116 patients with CCM were included. Logistic regression analysis showed a significant correlation (OR: 0.520, 95% CI: 0.284–0.951, p = 0.034) between antithrombotic therapy and ICH as a mode of presentation. Cox regression analysis revealed no significant correlation between medication intake and occurrence of (re-)hemorrhage (hazard ratios: betablockers 1.270 [95% CI: 0.703–2.293], statins 0.543 [95% CI: 0.194–1.526], antithrombotic therapy 0.507 [95% CI: 0.182–1.410], and thyroid hormones 0.834 [95% CI: 0.378–1.839]).ConclusionIn this observational study, antithrombotic treatment was associated with the tendency to a lower rate of ICH as a mode of presentation in a large cohort of patients with sporadic CCM. Intake of beta blockers, statins, and thyroid hormones had no effect on hemorrhage as a mode of presentation. During the 5-year follow-up period, none of the drugs affected the further risk of (re-)hemorrhage. |
| first_indexed | 2024-04-11T00:58:15Z |
| format | Article |
| id | doaj.art-fb7f196795cc44878a6fc0c2180876a6 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-11T00:58:15Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-fb7f196795cc44878a6fc0c2180876a62023-01-04T22:36:07ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-01-011310.3389/fneur.2022.10101701010170Effects of medication intake on the risk of hemorrhage in patients with sporadic cerebral cavernous malformationsBixia Chen0Kirstin Lahl1Dino Saban2Annika Lenkeit3Laurèl Rauschenbach4Alejandro N. Santos5Yan Li6Boerge Schmidt7Yuan Zhu8Ramazan Jabbarli9Karsten H. Wrede10Christoph Kleinschnitz11Ulrich Sure12Philipp Dammann13Department of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyInstitute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyDepartment of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyObjectiveRecurrent intracerebral hemorrhage (ICH) poses a high risk for patients with cerebral cavernous malformations (CCMs). This study aimed to assess the influence of medication intake on hemorrhage risk in sporadic CCMs.MethodsFrom a database of 1,409 consecutive patients with CCM (2003–2021), subjects with sporadic CCMs and complete magnetic resonance imaging data were included. We evaluated the presence of ICH as a mode of presentation, the occurrence of ICH during follow-up, and medication intake, including beta blockers, statins, antithrombotic therapy, and thyroid hormones. The impact of medication intake on ICH at presentation was calculated using univariate and multivariate logistic regression with age and sex adjustment. The longitudinal cumulative 5-year risk for (re-)hemorrhage was analyzed using the Kaplan–Meier curves and the Cox regression analysis.ResultsA total of 1116 patients with CCM were included. Logistic regression analysis showed a significant correlation (OR: 0.520, 95% CI: 0.284–0.951, p = 0.034) between antithrombotic therapy and ICH as a mode of presentation. Cox regression analysis revealed no significant correlation between medication intake and occurrence of (re-)hemorrhage (hazard ratios: betablockers 1.270 [95% CI: 0.703–2.293], statins 0.543 [95% CI: 0.194–1.526], antithrombotic therapy 0.507 [95% CI: 0.182–1.410], and thyroid hormones 0.834 [95% CI: 0.378–1.839]).ConclusionIn this observational study, antithrombotic treatment was associated with the tendency to a lower rate of ICH as a mode of presentation in a large cohort of patients with sporadic CCM. Intake of beta blockers, statins, and thyroid hormones had no effect on hemorrhage as a mode of presentation. During the 5-year follow-up period, none of the drugs affected the further risk of (re-)hemorrhage.https://www.frontiersin.org/articles/10.3389/fneur.2022.1010170/fullcavernous malformationmedicationintracerebral hemorrhagehemorrhage riskbeta blockerstatin |
| spellingShingle | Bixia Chen Kirstin Lahl Dino Saban Annika Lenkeit Laurèl Rauschenbach Alejandro N. Santos Yan Li Boerge Schmidt Yuan Zhu Ramazan Jabbarli Karsten H. Wrede Christoph Kleinschnitz Ulrich Sure Philipp Dammann Effects of medication intake on the risk of hemorrhage in patients with sporadic cerebral cavernous malformations Frontiers in Neurology cavernous malformation medication intracerebral hemorrhage hemorrhage risk beta blocker statin |
| title | Effects of medication intake on the risk of hemorrhage in patients with sporadic cerebral cavernous malformations |
| title_full | Effects of medication intake on the risk of hemorrhage in patients with sporadic cerebral cavernous malformations |
| title_fullStr | Effects of medication intake on the risk of hemorrhage in patients with sporadic cerebral cavernous malformations |
| title_full_unstemmed | Effects of medication intake on the risk of hemorrhage in patients with sporadic cerebral cavernous malformations |
| title_short | Effects of medication intake on the risk of hemorrhage in patients with sporadic cerebral cavernous malformations |
| title_sort | effects of medication intake on the risk of hemorrhage in patients with sporadic cerebral cavernous malformations |
| topic | cavernous malformation medication intracerebral hemorrhage hemorrhage risk beta blocker statin |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.1010170/full |
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