Evaluation of the effects of DBS in the caudal Zona incerta on brain activity during a working memory task in patients with essential tremor
Essential tremor (ET) is characterized by bilateral upper limb postural and/or kinetic tremor, but also cognitive deficits. Tremor in ET, as well as aspects of cognitive deficits associated with ET, have been suggested to be linked to dysfunction in the cerebello-thalamo-cerebral circuit. In ET pati...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Neuroimage: Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666956023000387 |
| _version_ | 1797398465058177024 |
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| author | Johanna Philipson Amar Awad Lena Lindström Patric Blomstedt Marjan Jahanshahi Johan Eriksson |
| author_facet | Johanna Philipson Amar Awad Lena Lindström Patric Blomstedt Marjan Jahanshahi Johan Eriksson |
| author_sort | Johanna Philipson |
| collection | DOAJ |
| description | Essential tremor (ET) is characterized by bilateral upper limb postural and/or kinetic tremor, but also cognitive deficits. Tremor in ET, as well as aspects of cognitive deficits associated with ET, have been suggested to be linked to dysfunction in the cerebello-thalamo-cerebral circuit. In ET patients with disabling and medically intractable motor symptoms, Deep Brain Stimulation (DBS) is effective in reducing tremor. DBS in the caudal Zona incerta (cZi) has been shown to modulate the activity of the sensorimotor cerebello-cerebral circuit during motor tasks. Whether the activity in the cerebello-cerebral circuit is modulated by DBS during tasks involving working memory is unknown. The present study therefore aimed to investigate the possible effects of cZi DBS on working-memory processing in ET patients by means of task-based blood oxygen level-dependent (BOLD) fMRI.Thirteen ET patients completed a working-memory task during DBS OFF and ON conditions. The task involved three conditions: maintenance, manipulation, and control. Behaviorally, there was no significant effect from DBS on accuracy, but a marginally significant Task x DBS interaction was detected for response times (RTs). However, post hoc comparisons for each condition failed to reach statistical significance. FMRI analyses revealed that DBS did not alter BOLD signal in regions of interest (lateral prefrontal cortex, parietal cortex, and the cerebellum), or in a complementary whole-brain analysis.The present study indicates that DBS in the cZi in patients with ET has at most marginal effects on working memory, which is consistent with the results of pre- and post-DBS neuropsychological assessment showing minimal cognitive effects of surgery. |
| first_indexed | 2024-03-09T01:25:57Z |
| format | Article |
| id | doaj.art-fb81eaee22004689822ad72739bb405a |
| institution | Directory Open Access Journal |
| issn | 2666-9560 |
| language | English |
| last_indexed | 2024-03-09T01:25:57Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neuroimage: Reports |
| spelling | doaj.art-fb81eaee22004689822ad72739bb405a2023-12-10T06:18:45ZengElsevierNeuroimage: Reports2666-95602023-12-0134100193Evaluation of the effects of DBS in the caudal Zona incerta on brain activity during a working memory task in patients with essential tremorJohanna Philipson0Amar Awad1Lena Lindström2Patric Blomstedt3Marjan Jahanshahi4Johan Eriksson5Department of Clinical Sciences, Neuroscience, Umeå University, Sweden; Corresponding author.Umeå Center for Functional Brain Imaging (UFBI), Dept. of Integrative Medical Biology, Umeå University, SwedenDepartment of Psychology, Lund University, Lund, SwedenDepartment of Clinical Sciences, Neuroscience, Umeå University, SwedenUnit of Functional Neurosurgery, UCL Queen Square Institute of Neurology, London, UKUmeå Center for Functional Brain Imaging (UFBI), Dept. of Integrative Medical Biology, Umeå University, SwedenEssential tremor (ET) is characterized by bilateral upper limb postural and/or kinetic tremor, but also cognitive deficits. Tremor in ET, as well as aspects of cognitive deficits associated with ET, have been suggested to be linked to dysfunction in the cerebello-thalamo-cerebral circuit. In ET patients with disabling and medically intractable motor symptoms, Deep Brain Stimulation (DBS) is effective in reducing tremor. DBS in the caudal Zona incerta (cZi) has been shown to modulate the activity of the sensorimotor cerebello-cerebral circuit during motor tasks. Whether the activity in the cerebello-cerebral circuit is modulated by DBS during tasks involving working memory is unknown. The present study therefore aimed to investigate the possible effects of cZi DBS on working-memory processing in ET patients by means of task-based blood oxygen level-dependent (BOLD) fMRI.Thirteen ET patients completed a working-memory task during DBS OFF and ON conditions. The task involved three conditions: maintenance, manipulation, and control. Behaviorally, there was no significant effect from DBS on accuracy, but a marginally significant Task x DBS interaction was detected for response times (RTs). However, post hoc comparisons for each condition failed to reach statistical significance. FMRI analyses revealed that DBS did not alter BOLD signal in regions of interest (lateral prefrontal cortex, parietal cortex, and the cerebellum), or in a complementary whole-brain analysis.The present study indicates that DBS in the cZi in patients with ET has at most marginal effects on working memory, which is consistent with the results of pre- and post-DBS neuropsychological assessment showing minimal cognitive effects of surgery.http://www.sciencedirect.com/science/article/pii/S2666956023000387Deep brain stimulationEssential tremorWorking memoryfMRI |
| spellingShingle | Johanna Philipson Amar Awad Lena Lindström Patric Blomstedt Marjan Jahanshahi Johan Eriksson Evaluation of the effects of DBS in the caudal Zona incerta on brain activity during a working memory task in patients with essential tremor Neuroimage: Reports Deep brain stimulation Essential tremor Working memory fMRI |
| title | Evaluation of the effects of DBS in the caudal Zona incerta on brain activity during a working memory task in patients with essential tremor |
| title_full | Evaluation of the effects of DBS in the caudal Zona incerta on brain activity during a working memory task in patients with essential tremor |
| title_fullStr | Evaluation of the effects of DBS in the caudal Zona incerta on brain activity during a working memory task in patients with essential tremor |
| title_full_unstemmed | Evaluation of the effects of DBS in the caudal Zona incerta on brain activity during a working memory task in patients with essential tremor |
| title_short | Evaluation of the effects of DBS in the caudal Zona incerta on brain activity during a working memory task in patients with essential tremor |
| title_sort | evaluation of the effects of dbs in the caudal zona incerta on brain activity during a working memory task in patients with essential tremor |
| topic | Deep brain stimulation Essential tremor Working memory fMRI |
| url | http://www.sciencedirect.com/science/article/pii/S2666956023000387 |
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