Combination of Haloperidol, Dexamethasone, and Ondansetron Reduces Nausea and Pain Intensity and Morphine Consumption after Laparoscopic Sleeve Gastrectomy
Background and objective: : Postoperative nausea and vomiting (PONV) occur frequently after laparoscopic bariatric surgery. The combination of haloperidol, dexamethasone, and ondansetron may reduce these undesirable events. The aim of this study was to evaluate the intensity of nausea and pain, the...
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| Format: | Article |
| Language: | English |
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Elsevier
2013-09-01
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| Series: | Brazilian Journal of Anesthesiology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0104001413001668 |
| _version_ | 1797998214385762304 |
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| author | Márcio Luiz Benevides Sérgio de Souza Oliveira José Eduardo Aguilar-Nascimento |
| author_facet | Márcio Luiz Benevides Sérgio de Souza Oliveira José Eduardo Aguilar-Nascimento |
| author_sort | Márcio Luiz Benevides |
| collection | DOAJ |
| description | Background and objective: : Postoperative nausea and vomiting (PONV) occur frequently after laparoscopic bariatric surgery. The combination of haloperidol, dexamethasone, and ondansetron may reduce these undesirable events. The aim of this study was to evaluate the intensity of nausea and pain, the number of vomiting episodes, and morphine consumption in postoperative (PO) obese patients undergoing laparoscopic sleeve gastrectomy (LSG). Method: A clinical, randomized, controlled, double-blind study conducted with 90 patients with body mass index ≥ 35 kg.cm-2. Patients were divided into three groups of 30 individuals to receive ondansetron 8 mg (Group O); ondansetron 8 mg and dexamethasone 8 mg (Group OD); and ondansetron 8 mg, dexamethasone 8 mg, and haloperidol 2 mg (Group HDO). We evaluated the intensity of nausea and pain using the verbal numeric scale, cumulative number of vomiting episodes, and morphine consumption in the period of 0-2, 2-12, 12-24, and 24-36 hours postoperatively. Results: Nausea intensity was lower in Group HDO compared to Group O (p = 0.001), pain intensity was lower in Group HDO compared to Group O (p = 0.046), and morphine consumption was lower in Group HDO compared to Group O (p = 0.037). There was no difference between groups regarding the number of vomiting episodes (p = 0.052). Conclusion: The combination of haloperidol, ondansetron, and dexamethasone reduced nausea and pain intensity and morphine consumption in postoperative obese patients undergoing LSG. Keywords: Antiemetics, Haloperidol, Dexamethasone, Ondansetron, Bariatric Surgery, Postoperative Nausea and Vomiting. |
| first_indexed | 2024-04-11T10:45:05Z |
| format | Article |
| id | doaj.art-fb83521d7e794e32a160fb5168e1b247 |
| institution | Directory Open Access Journal |
| issn | 0104-0014 |
| language | English |
| last_indexed | 2024-04-11T10:45:05Z |
| publishDate | 2013-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Anesthesiology |
| spelling | doaj.art-fb83521d7e794e32a160fb5168e1b2472022-12-22T04:29:05ZengElsevierBrazilian Journal of Anesthesiology0104-00142013-09-01635404409Combination of Haloperidol, Dexamethasone, and Ondansetron Reduces Nausea and Pain Intensity and Morphine Consumption after Laparoscopic Sleeve GastrectomyMárcio Luiz Benevides0Sérgio de Souza Oliveira1José Eduardo Aguilar-Nascimento2Center for Teaching and Training, Sociedade Brasileira de Anestesiologia, Cuiabá, MT, Brazil; Corresponding author. Universidade Federal de Mato Grosso, Avenida Fernando Corrêa da Costa s/n, Boa Esperança, Cuiabá, MT, Brasil. CEP: 78 068-600.Center for Teaching and Training, Sociedade Brasileira de Anestesiologia, Cuiabá, MT, Brazil; Department of Surgery, Hospital Universitário Júlio Müller, Universidade Federal de Mato Grosso, Cuiabá, MT, BrazilDepartment of Surgery, Hospital Universitário Júlio Müller, Universidade Federal de Mato Grosso, Cuiabá, MT, BrazilBackground and objective: : Postoperative nausea and vomiting (PONV) occur frequently after laparoscopic bariatric surgery. The combination of haloperidol, dexamethasone, and ondansetron may reduce these undesirable events. The aim of this study was to evaluate the intensity of nausea and pain, the number of vomiting episodes, and morphine consumption in postoperative (PO) obese patients undergoing laparoscopic sleeve gastrectomy (LSG). Method: A clinical, randomized, controlled, double-blind study conducted with 90 patients with body mass index ≥ 35 kg.cm-2. Patients were divided into three groups of 30 individuals to receive ondansetron 8 mg (Group O); ondansetron 8 mg and dexamethasone 8 mg (Group OD); and ondansetron 8 mg, dexamethasone 8 mg, and haloperidol 2 mg (Group HDO). We evaluated the intensity of nausea and pain using the verbal numeric scale, cumulative number of vomiting episodes, and morphine consumption in the period of 0-2, 2-12, 12-24, and 24-36 hours postoperatively. Results: Nausea intensity was lower in Group HDO compared to Group O (p = 0.001), pain intensity was lower in Group HDO compared to Group O (p = 0.046), and morphine consumption was lower in Group HDO compared to Group O (p = 0.037). There was no difference between groups regarding the number of vomiting episodes (p = 0.052). Conclusion: The combination of haloperidol, ondansetron, and dexamethasone reduced nausea and pain intensity and morphine consumption in postoperative obese patients undergoing LSG. Keywords: Antiemetics, Haloperidol, Dexamethasone, Ondansetron, Bariatric Surgery, Postoperative Nausea and Vomiting.http://www.sciencedirect.com/science/article/pii/S0104001413001668 |
| spellingShingle | Márcio Luiz Benevides Sérgio de Souza Oliveira José Eduardo Aguilar-Nascimento Combination of Haloperidol, Dexamethasone, and Ondansetron Reduces Nausea and Pain Intensity and Morphine Consumption after Laparoscopic Sleeve Gastrectomy Brazilian Journal of Anesthesiology |
| title | Combination of Haloperidol, Dexamethasone, and Ondansetron Reduces Nausea and Pain Intensity and Morphine Consumption after Laparoscopic Sleeve Gastrectomy |
| title_full | Combination of Haloperidol, Dexamethasone, and Ondansetron Reduces Nausea and Pain Intensity and Morphine Consumption after Laparoscopic Sleeve Gastrectomy |
| title_fullStr | Combination of Haloperidol, Dexamethasone, and Ondansetron Reduces Nausea and Pain Intensity and Morphine Consumption after Laparoscopic Sleeve Gastrectomy |
| title_full_unstemmed | Combination of Haloperidol, Dexamethasone, and Ondansetron Reduces Nausea and Pain Intensity and Morphine Consumption after Laparoscopic Sleeve Gastrectomy |
| title_short | Combination of Haloperidol, Dexamethasone, and Ondansetron Reduces Nausea and Pain Intensity and Morphine Consumption after Laparoscopic Sleeve Gastrectomy |
| title_sort | combination of haloperidol dexamethasone and ondansetron reduces nausea and pain intensity and morphine consumption after laparoscopic sleeve gastrectomy |
| url | http://www.sciencedirect.com/science/article/pii/S0104001413001668 |
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