Metabolities from Marine Sponges of the Genus <i>Callyspongia</i>: Occurrence, Biological Activity, and NMR Data
The genus <i>Callyspongia</i> (Callyspongiidae) encompasses a group of demosponges including 261 described species, of which approximately 180 have been accepted after taxonomic reviews. The marine organisms of <i>Callyspongia</i> are distributed in tropical ecosystems, espec...
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| Format: | Article |
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MDPI AG
2021-11-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/19/12/663 |
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| author | Lucas Hilário Nogueira de Sousa Rusceli Diego de Araújo Déborah Sousa-Fontoura Fabrício Gava Menezes Renata Mendonça Araújo |
| author_facet | Lucas Hilário Nogueira de Sousa Rusceli Diego de Araújo Déborah Sousa-Fontoura Fabrício Gava Menezes Renata Mendonça Araújo |
| author_sort | Lucas Hilário Nogueira de Sousa |
| collection | DOAJ |
| description | The genus <i>Callyspongia</i> (Callyspongiidae) encompasses a group of demosponges including 261 described species, of which approximately 180 have been accepted after taxonomic reviews. The marine organisms of <i>Callyspongia</i> are distributed in tropical ecosystems, especially in the central and western Pacific, but also in the regions of the Indian, the West Atlantic, and the East Pacific Oceans. The reason for the interest in the genus <i>Callyspongia</i> is related to its potential production of bioactive compounds. In this review, we group the chemical information about the metabolites isolated from the genus <i>Callyspongia</i>, as well as studies of the biological activity of these compounds. Through NMR data, 212 metabolites were identified from genus <i>Callyspongia</i> (15 species and <i>Callyspongia</i> sp.), belonging to classes such as polyacetylenes, terpenoids, steroids, alkaloids, polyketides, simple phenols, phenylpropanoids, nucleosides, cyclic peptides, and cyclic depsipeptides. A total of 109 molecules have been reported with bioactive activity, mainly cytotoxic and antimicrobial (antibacterial and antifungal) action. Thus, we conclude that polyacetylenes, terpenoids and steroids correspond to the largest classes of compounds of the genus, and that future research involving the anticancer action of the species’ bioactive metabolites may become relevant. |
| first_indexed | 2024-03-10T03:41:36Z |
| format | Article |
| id | doaj.art-fb83e238626c4befa0bc0324f86cf904 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T03:41:36Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-fb83e238626c4befa0bc0324f86cf9042023-11-23T09:17:55ZengMDPI AGMarine Drugs1660-33972021-11-01191266310.3390/md19120663Metabolities from Marine Sponges of the Genus <i>Callyspongia</i>: Occurrence, Biological Activity, and NMR DataLucas Hilário Nogueira de Sousa0Rusceli Diego de Araújo1Déborah Sousa-Fontoura2Fabrício Gava Menezes3Renata Mendonça Araújo4Instituto de Química, Universidade Federal do Rio Grande do Norte, Natal 59078-970, BrazilInstituto de Química, Universidade Federal do Rio Grande do Norte, Natal 59078-970, BrazilBiotério Central, Universidade Federal do Rio Grande do Norte, Natal 59078-970, BrazilInstituto de Química, Universidade Federal do Rio Grande do Norte, Natal 59078-970, BrazilInstituto de Química, Universidade Federal do Rio Grande do Norte, Natal 59078-970, BrazilThe genus <i>Callyspongia</i> (Callyspongiidae) encompasses a group of demosponges including 261 described species, of which approximately 180 have been accepted after taxonomic reviews. The marine organisms of <i>Callyspongia</i> are distributed in tropical ecosystems, especially in the central and western Pacific, but also in the regions of the Indian, the West Atlantic, and the East Pacific Oceans. The reason for the interest in the genus <i>Callyspongia</i> is related to its potential production of bioactive compounds. In this review, we group the chemical information about the metabolites isolated from the genus <i>Callyspongia</i>, as well as studies of the biological activity of these compounds. Through NMR data, 212 metabolites were identified from genus <i>Callyspongia</i> (15 species and <i>Callyspongia</i> sp.), belonging to classes such as polyacetylenes, terpenoids, steroids, alkaloids, polyketides, simple phenols, phenylpropanoids, nucleosides, cyclic peptides, and cyclic depsipeptides. A total of 109 molecules have been reported with bioactive activity, mainly cytotoxic and antimicrobial (antibacterial and antifungal) action. Thus, we conclude that polyacetylenes, terpenoids and steroids correspond to the largest classes of compounds of the genus, and that future research involving the anticancer action of the species’ bioactive metabolites may become relevant.https://www.mdpi.com/1660-3397/19/12/663demosponges<i>Callyspongia</i>polyacetylenesanticancer action |
| spellingShingle | Lucas Hilário Nogueira de Sousa Rusceli Diego de Araújo Déborah Sousa-Fontoura Fabrício Gava Menezes Renata Mendonça Araújo Metabolities from Marine Sponges of the Genus <i>Callyspongia</i>: Occurrence, Biological Activity, and NMR Data Marine Drugs demosponges <i>Callyspongia</i> polyacetylenes anticancer action |
| title | Metabolities from Marine Sponges of the Genus <i>Callyspongia</i>: Occurrence, Biological Activity, and NMR Data |
| title_full | Metabolities from Marine Sponges of the Genus <i>Callyspongia</i>: Occurrence, Biological Activity, and NMR Data |
| title_fullStr | Metabolities from Marine Sponges of the Genus <i>Callyspongia</i>: Occurrence, Biological Activity, and NMR Data |
| title_full_unstemmed | Metabolities from Marine Sponges of the Genus <i>Callyspongia</i>: Occurrence, Biological Activity, and NMR Data |
| title_short | Metabolities from Marine Sponges of the Genus <i>Callyspongia</i>: Occurrence, Biological Activity, and NMR Data |
| title_sort | metabolities from marine sponges of the genus i callyspongia i occurrence biological activity and nmr data |
| topic | demosponges <i>Callyspongia</i> polyacetylenes anticancer action |
| url | https://www.mdpi.com/1660-3397/19/12/663 |
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