Protein Glycoengineering: An Approach for Improving Protein Properties
Natural proteins are an important source of therapeutic agents and industrial enzymes. While many of them have the potential to be used as highly effective medical treatments for a wide range of diseases or as catalysts for conversion of a range of molecules into important product types required by...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-07-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fchem.2020.00622/full |
| _version_ | 1818510999698800640 |
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| author | Bo Ma Xiaoyang Guan Yaohao Li Yaohao Li Shiying Shang Jing Li Zhongping Tan |
| author_facet | Bo Ma Xiaoyang Guan Yaohao Li Yaohao Li Shiying Shang Jing Li Zhongping Tan |
| author_sort | Bo Ma |
| collection | DOAJ |
| description | Natural proteins are an important source of therapeutic agents and industrial enzymes. While many of them have the potential to be used as highly effective medical treatments for a wide range of diseases or as catalysts for conversion of a range of molecules into important product types required by modern society, problems associated with poor biophysical and biological properties have limited their applications. Engineering proteins with reduced side-effects and/or improved biophysical and biological properties is therefore of great importance. As a common protein modification, glycosylation has the capacity to greatly influence these properties. Over the past three decades, research from many disciplines has established the importance of glycoengineering in overcoming the limitations of proteins. In this review, we will summarize the methods that have been used to glycoengineer proteins and briefly discuss some representative examples of these methods, with the goal of providing a general overview of this research area. |
| first_indexed | 2024-12-10T23:27:35Z |
| format | Article |
| id | doaj.art-fb84deba38b047f8b34c0af64790ffbd |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-10T23:27:35Z |
| publishDate | 2020-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-fb84deba38b047f8b34c0af64790ffbd2022-12-22T01:29:33ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462020-07-01810.3389/fchem.2020.00622543737Protein Glycoengineering: An Approach for Improving Protein PropertiesBo Ma0Xiaoyang Guan1Yaohao Li2Yaohao Li3Shiying Shang4Jing Li5Zhongping Tan6State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Chemistry and Biochemistry and BioFrontiers Institute, University of Colorado, Boulder, CO, United StatesState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Chemistry and Biochemistry and BioFrontiers Institute, University of Colorado, Boulder, CO, United StatesSchool of Pharmaceutical Sciences, Tsinghua University, Beijing, ChinaBeijing Key Laboratory of DNA Damage Response and College of Life Sciences, Capital Normal University, Beijing, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaNatural proteins are an important source of therapeutic agents and industrial enzymes. While many of them have the potential to be used as highly effective medical treatments for a wide range of diseases or as catalysts for conversion of a range of molecules into important product types required by modern society, problems associated with poor biophysical and biological properties have limited their applications. Engineering proteins with reduced side-effects and/or improved biophysical and biological properties is therefore of great importance. As a common protein modification, glycosylation has the capacity to greatly influence these properties. Over the past three decades, research from many disciplines has established the importance of glycoengineering in overcoming the limitations of proteins. In this review, we will summarize the methods that have been used to glycoengineer proteins and briefly discuss some representative examples of these methods, with the goal of providing a general overview of this research area.https://www.frontiersin.org/article/10.3389/fchem.2020.00622/fullglycoengineeringtherapeutic proteinenzymebiological methodchemical method |
| spellingShingle | Bo Ma Xiaoyang Guan Yaohao Li Yaohao Li Shiying Shang Jing Li Zhongping Tan Protein Glycoengineering: An Approach for Improving Protein Properties Frontiers in Chemistry glycoengineering therapeutic protein enzyme biological method chemical method |
| title | Protein Glycoengineering: An Approach for Improving Protein Properties |
| title_full | Protein Glycoengineering: An Approach for Improving Protein Properties |
| title_fullStr | Protein Glycoengineering: An Approach for Improving Protein Properties |
| title_full_unstemmed | Protein Glycoengineering: An Approach for Improving Protein Properties |
| title_short | Protein Glycoengineering: An Approach for Improving Protein Properties |
| title_sort | protein glycoengineering an approach for improving protein properties |
| topic | glycoengineering therapeutic protein enzyme biological method chemical method |
| url | https://www.frontiersin.org/article/10.3389/fchem.2020.00622/full |
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