Exosomal ANGPTL1 attenuates colorectal cancer liver metastasis by regulating Kupffer cell secretion pattern and impeding MMP9 induced vascular leakiness

Exosomal ANGPTL1 attenuates colorectal cancer liver metastasis by regulating Kupffer cell secretion pattern and impeding MMP9 induced vascular leakiness

Abstract Background Angiopoietin-like protein 1 (ANGPTL1) has been proved to suppress tumor metastasis in several cancers. However, its extracellular effects on the pre-metastatic niches (PMNs) are still unclear. ANGPTL1 has been identified in exosomes, while its function remains unknown. This study...

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Bibliographic Details
Main Authors: Kai Jiang, Haiyan Chen, Yimin Fang, Liubo Chen, Chenhan Zhong, Tongtong Bu, Siqi Dai, Xiang Pan, Dongliang Fu, Yucheng Qian, Jingsun Wei, Kefeng Ding
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Exosomal ANGPTL1
Colorectal Cancer
Liver metastasis
PMNs
Kupffer cell
MMP9
Online Access:https://doi.org/10.1186/s13046-020-01816-3

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