Sequence Does Not Matter: The Biomedical Applications of DNA-Based Coatings and Cores
Biomedical applications of DNA are diverse but are usually associated with specific recognition of target nucleotide sequences or proteins and with gene delivery for therapeutic or biotechnological purposes. However, other aspects of DNA functionalities, like its nontoxicity, biodegradability, polye...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-11-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/23/12884 |
| _version_ | 1797507748066230272 |
|---|---|
| author | Svetlana Batasheva Rawil Fakhrullin |
| author_facet | Svetlana Batasheva Rawil Fakhrullin |
| author_sort | Svetlana Batasheva |
| collection | DOAJ |
| description | Biomedical applications of DNA are diverse but are usually associated with specific recognition of target nucleotide sequences or proteins and with gene delivery for therapeutic or biotechnological purposes. However, other aspects of DNA functionalities, like its nontoxicity, biodegradability, polyelectrolyte nature, stability, thermo-responsivity and charge transfer ability that are rather independent of its sequence, have recently become highly appreciated in material science and biomedicine. Whereas the latest achievements in structural DNA nanotechnology associated with DNA sequence recognition and Watson–Crick base pairing between complementary nucleotides are regularly reviewed, the recent uses of DNA as a raw material in biomedicine have not been summarized. This review paper describes the main biomedical applications of DNA that do not involve any synthesis or extraction of oligo- or polynucleotides with specified sequences. These sequence-independent applications currently include some types of drug delivery systems, biocompatible coatings, fire retardant and antimicrobial coatings and biosensors. The reinforcement of DNA properties by DNA complexation with nanoparticles is also described as a field of further research. |
| first_indexed | 2024-03-10T04:53:52Z |
| format | Article |
| id | doaj.art-fb86ef868af9421985fb8c78a0bdfb40 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:53:52Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-fb86ef868af9421985fb8c78a0bdfb402023-11-23T02:29:40ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-11-0122231288410.3390/ijms222312884Sequence Does Not Matter: The Biomedical Applications of DNA-Based Coatings and CoresSvetlana Batasheva0Rawil Fakhrullin1Institute of Fundamental Medicine and Biology, Kazan Federal University, Kreml Uramı 18, 420008 Kazan, Republic of Tatarstan, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kreml Uramı 18, 420008 Kazan, Republic of Tatarstan, RussiaBiomedical applications of DNA are diverse but are usually associated with specific recognition of target nucleotide sequences or proteins and with gene delivery for therapeutic or biotechnological purposes. However, other aspects of DNA functionalities, like its nontoxicity, biodegradability, polyelectrolyte nature, stability, thermo-responsivity and charge transfer ability that are rather independent of its sequence, have recently become highly appreciated in material science and biomedicine. Whereas the latest achievements in structural DNA nanotechnology associated with DNA sequence recognition and Watson–Crick base pairing between complementary nucleotides are regularly reviewed, the recent uses of DNA as a raw material in biomedicine have not been summarized. This review paper describes the main biomedical applications of DNA that do not involve any synthesis or extraction of oligo- or polynucleotides with specified sequences. These sequence-independent applications currently include some types of drug delivery systems, biocompatible coatings, fire retardant and antimicrobial coatings and biosensors. The reinforcement of DNA properties by DNA complexation with nanoparticles is also described as a field of further research.https://www.mdpi.com/1422-0067/22/23/12884layer-by-layer assemblypolyelectrolyte multilayerstissue scaffoldimplantflame retardancydrug delivery |
| spellingShingle | Svetlana Batasheva Rawil Fakhrullin Sequence Does Not Matter: The Biomedical Applications of DNA-Based Coatings and Cores International Journal of Molecular Sciences layer-by-layer assembly polyelectrolyte multilayers tissue scaffold implant flame retardancy drug delivery |
| title | Sequence Does Not Matter: The Biomedical Applications of DNA-Based Coatings and Cores |
| title_full | Sequence Does Not Matter: The Biomedical Applications of DNA-Based Coatings and Cores |
| title_fullStr | Sequence Does Not Matter: The Biomedical Applications of DNA-Based Coatings and Cores |
| title_full_unstemmed | Sequence Does Not Matter: The Biomedical Applications of DNA-Based Coatings and Cores |
| title_short | Sequence Does Not Matter: The Biomedical Applications of DNA-Based Coatings and Cores |
| title_sort | sequence does not matter the biomedical applications of dna based coatings and cores |
| topic | layer-by-layer assembly polyelectrolyte multilayers tissue scaffold implant flame retardancy drug delivery |
| url | https://www.mdpi.com/1422-0067/22/23/12884 |
| work_keys_str_mv | AT svetlanabatasheva sequencedoesnotmatterthebiomedicalapplicationsofdnabasedcoatingsandcores AT rawilfakhrullin sequencedoesnotmatterthebiomedicalapplicationsofdnabasedcoatingsandcores |