Relationship between bilirubin and systemic lupus erythematosus: A systematic review and meta‐analysis
Abstract Aims Systemic lupus erythematosus (SLE) is an autoimmune disease with a high prevalence worldwide. This study aimed to examine the correlation between serum bilirubin levels and SLE. Methods The Cochrane library, Embase, PubMed, and China National Knowledge Infrastructure (CNKI) databases w...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-12-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.1115 |
| _version_ | 1797372760482119680 |
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| author | Yanxia Yu Qiaoyu Wang Dongmei Zhang Weihua Wu Zheng Jiang |
| author_facet | Yanxia Yu Qiaoyu Wang Dongmei Zhang Weihua Wu Zheng Jiang |
| author_sort | Yanxia Yu |
| collection | DOAJ |
| description | Abstract Aims Systemic lupus erythematosus (SLE) is an autoimmune disease with a high prevalence worldwide. This study aimed to examine the correlation between serum bilirubin levels and SLE. Methods The Cochrane library, Embase, PubMed, and China National Knowledge Infrastructure (CNKI) databases were examined and assessed until March 2023. RevMan 5.3 software was utilized for the analysis of clinical trails. Results Five case‐control studies were chosen and incorporated, examining the levels of serum bilirubin in patients with SLE compared to healthy individuals, as well as in active SLE patients versus inactive ones, in different sexes and in SLE patients with or without lupus nephritis (LN). The results of this meta‐analysis demonstrated that serum bilirubin in healthy individuals were obviously increased compared to SLE patients (MD = 4.76; 95% CI, 3.15–6.38, p < .00001). Additionally, inactive SLE patients had higher levels of bilirubin than active SLE patients (MD = 3.15; 95% CI, 0.46–5.84, p = .02), and SLE patients without lupus nephritis had higher levels of serum bilirubin than those with lupus nephritis (MD = 4.91;95% CI, 2.87–6.95, p < .00001). Nevertheless, there were no disparities observed among SLE patients of varying sexes (MD = 0.34; 95% CI, −0.01 to 0.69, p = .06). Conclusion The concentration of serum bilirubin may potentially be used as an indicator for estimating the advancement of SLE and reflecting the presence of kidney complications in individuals with SLE. Furthermore, more high quality studies were needed to identify these findings. |
| first_indexed | 2024-03-08T18:40:29Z |
| format | Article |
| id | doaj.art-fb87eb40fe9744149ee57d5d7c7db5f4 |
| institution | Directory Open Access Journal |
| issn | 2050-4527 |
| language | English |
| last_indexed | 2024-03-08T18:40:29Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj.art-fb87eb40fe9744149ee57d5d7c7db5f42023-12-29T08:52:36ZengWileyImmunity, Inflammation and Disease2050-45272023-12-011112n/an/a10.1002/iid3.1115Relationship between bilirubin and systemic lupus erythematosus: A systematic review and meta‐analysisYanxia Yu0Qiaoyu Wang1Dongmei Zhang2Weihua Wu3Zheng Jiang4Department of Nephrology The Affiliated Hospital of Southwest Medical University Luzhou ChinaDepartment of Nephrology The Affiliated Hospital of Southwest Medical University Luzhou ChinaDepartment of Nephrology The Affiliated Hospital of Southwest Medical University Luzhou ChinaDepartment of Nephrology The Affiliated Hospital of Southwest Medical University Luzhou ChinaDepartment of Nephrology The Affiliated Hospital of Southwest Medical University Luzhou ChinaAbstract Aims Systemic lupus erythematosus (SLE) is an autoimmune disease with a high prevalence worldwide. This study aimed to examine the correlation between serum bilirubin levels and SLE. Methods The Cochrane library, Embase, PubMed, and China National Knowledge Infrastructure (CNKI) databases were examined and assessed until March 2023. RevMan 5.3 software was utilized for the analysis of clinical trails. Results Five case‐control studies were chosen and incorporated, examining the levels of serum bilirubin in patients with SLE compared to healthy individuals, as well as in active SLE patients versus inactive ones, in different sexes and in SLE patients with or without lupus nephritis (LN). The results of this meta‐analysis demonstrated that serum bilirubin in healthy individuals were obviously increased compared to SLE patients (MD = 4.76; 95% CI, 3.15–6.38, p < .00001). Additionally, inactive SLE patients had higher levels of bilirubin than active SLE patients (MD = 3.15; 95% CI, 0.46–5.84, p = .02), and SLE patients without lupus nephritis had higher levels of serum bilirubin than those with lupus nephritis (MD = 4.91;95% CI, 2.87–6.95, p < .00001). Nevertheless, there were no disparities observed among SLE patients of varying sexes (MD = 0.34; 95% CI, −0.01 to 0.69, p = .06). Conclusion The concentration of serum bilirubin may potentially be used as an indicator for estimating the advancement of SLE and reflecting the presence of kidney complications in individuals with SLE. Furthermore, more high quality studies were needed to identify these findings.https://doi.org/10.1002/iid3.1115lupus nephritisserum bilirubinsystemic lupus erythematosus |
| spellingShingle | Yanxia Yu Qiaoyu Wang Dongmei Zhang Weihua Wu Zheng Jiang Relationship between bilirubin and systemic lupus erythematosus: A systematic review and meta‐analysis Immunity, Inflammation and Disease lupus nephritis serum bilirubin systemic lupus erythematosus |
| title | Relationship between bilirubin and systemic lupus erythematosus: A systematic review and meta‐analysis |
| title_full | Relationship between bilirubin and systemic lupus erythematosus: A systematic review and meta‐analysis |
| title_fullStr | Relationship between bilirubin and systemic lupus erythematosus: A systematic review and meta‐analysis |
| title_full_unstemmed | Relationship between bilirubin and systemic lupus erythematosus: A systematic review and meta‐analysis |
| title_short | Relationship between bilirubin and systemic lupus erythematosus: A systematic review and meta‐analysis |
| title_sort | relationship between bilirubin and systemic lupus erythematosus a systematic review and meta analysis |
| topic | lupus nephritis serum bilirubin systemic lupus erythematosus |
| url | https://doi.org/10.1002/iid3.1115 |
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