Lifestyle Changes in Relation to Initiation of Antihypertensive and Lipid‐Lowering Medication: A Cohort Study
Background Lifestyle modification is a key component of cardiovascular disease prevention before and concurrently with pharmacologic interventions. We evaluated whether lifestyle factors change in relation to the initiation of antihypertensive or lipid‐lowering medication (statins). Methods and Resu...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-02-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.119.014168 |
| _version_ | 1797884448735232000 |
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| author | Maarit J. Korhonen Jaana Pentti Juha Hartikainen Jenni Ilomäki Soko Setoguchi Danny Liew Mika Kivimäki Jussi Vahtera |
| author_facet | Maarit J. Korhonen Jaana Pentti Juha Hartikainen Jenni Ilomäki Soko Setoguchi Danny Liew Mika Kivimäki Jussi Vahtera |
| author_sort | Maarit J. Korhonen |
| collection | DOAJ |
| description | Background Lifestyle modification is a key component of cardiovascular disease prevention before and concurrently with pharmacologic interventions. We evaluated whether lifestyle factors change in relation to the initiation of antihypertensive or lipid‐lowering medication (statins). Methods and Results The study population comprised 41 225 participants of the FPS (Finnish Public Sector) study aged ≥40 years who were free of cardiovascular disease at baseline and responded to ≥2 consecutive surveys administered in 4‐year intervals in 2000–2013. Medication use was ascertained through pharmacy‐claims data. Using a series of pre–post data sets, we compared changes in body mass index, physical activity, alcohol consumption, and smoking between 8837 initiators and 46 021 noninitiators of antihypertensive medications or statins. In participants who initiated medication use, body mass index increased more (difference in change 0.19; 95% CI, 0.16–0.22) and physical activity declined (−0.09 metabolic equivalent of task hour/day; 95% CI, −0.16 to −0.02) compared with noninitiators. The likelihood of becoming obese (odds ratio: 1.82; 95% CI, 1.63–2.03) and physically inactive (odds ratio: 1.08; 95% CI, 1.01–1.17) was higher in initiators. However, medication initiation was associated with greater decline in average alcohol consumption (−1.85 g/week; 95% CI, −3.67 to −0.14) and higher odds of quitting smoking (odds ratio for current smoking in the second survey: 0.74; 95% CI, 0.64–0.85). Conclusions These findings suggest that initiation of antihypertensive and statin medication is associated with lifestyle changes, some favorable and others unfavorable. Weight management and physical activity should be encouraged in individuals prescribed these medications. |
| first_indexed | 2024-04-10T04:06:26Z |
| format | Article |
| id | doaj.art-fb894147cadc4d329853c3db3e9362da |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-10T04:06:26Z |
| publishDate | 2020-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-fb894147cadc4d329853c3db3e9362da2023-03-13T05:25:33ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802020-02-019410.1161/JAHA.119.014168Lifestyle Changes in Relation to Initiation of Antihypertensive and Lipid‐Lowering Medication: A Cohort StudyMaarit J. Korhonen0Jaana Pentti1Juha Hartikainen2Jenni Ilomäki3Soko Setoguchi4Danny Liew5Mika Kivimäki6Jussi Vahtera7Department of Public Health University of Turku FinlandFinnish Institute of Occupational Health Helsinki FinlandHeart Center Kuopio University Hospital Kuopio FinlandCentre for Medicine Use and Safety Faculty of Pharmacy and Pharmaceutical Sciences Monash University Melbourne Victoria AustraliaRutgers School of Public Health and Rutgers Robert Wood Johnson Medical School New Brunswick NJSchool of Public Health and Preventive Medicine Monash University Melbourne Victoria AustraliaFinnish Institute of Occupational Health Helsinki FinlandDepartment of Public Health University of Turku FinlandBackground Lifestyle modification is a key component of cardiovascular disease prevention before and concurrently with pharmacologic interventions. We evaluated whether lifestyle factors change in relation to the initiation of antihypertensive or lipid‐lowering medication (statins). Methods and Results The study population comprised 41 225 participants of the FPS (Finnish Public Sector) study aged ≥40 years who were free of cardiovascular disease at baseline and responded to ≥2 consecutive surveys administered in 4‐year intervals in 2000–2013. Medication use was ascertained through pharmacy‐claims data. Using a series of pre–post data sets, we compared changes in body mass index, physical activity, alcohol consumption, and smoking between 8837 initiators and 46 021 noninitiators of antihypertensive medications or statins. In participants who initiated medication use, body mass index increased more (difference in change 0.19; 95% CI, 0.16–0.22) and physical activity declined (−0.09 metabolic equivalent of task hour/day; 95% CI, −0.16 to −0.02) compared with noninitiators. The likelihood of becoming obese (odds ratio: 1.82; 95% CI, 1.63–2.03) and physically inactive (odds ratio: 1.08; 95% CI, 1.01–1.17) was higher in initiators. However, medication initiation was associated with greater decline in average alcohol consumption (−1.85 g/week; 95% CI, −3.67 to −0.14) and higher odds of quitting smoking (odds ratio for current smoking in the second survey: 0.74; 95% CI, 0.64–0.85). Conclusions These findings suggest that initiation of antihypertensive and statin medication is associated with lifestyle changes, some favorable and others unfavorable. Weight management and physical activity should be encouraged in individuals prescribed these medications.https://www.ahajournals.org/doi/10.1161/JAHA.119.014168antihypertensive agentslifestylelongitudinalprimary preventionstatins |
| spellingShingle | Maarit J. Korhonen Jaana Pentti Juha Hartikainen Jenni Ilomäki Soko Setoguchi Danny Liew Mika Kivimäki Jussi Vahtera Lifestyle Changes in Relation to Initiation of Antihypertensive and Lipid‐Lowering Medication: A Cohort Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease antihypertensive agents lifestyle longitudinal primary prevention statins |
| title | Lifestyle Changes in Relation to Initiation of Antihypertensive and Lipid‐Lowering Medication: A Cohort Study |
| title_full | Lifestyle Changes in Relation to Initiation of Antihypertensive and Lipid‐Lowering Medication: A Cohort Study |
| title_fullStr | Lifestyle Changes in Relation to Initiation of Antihypertensive and Lipid‐Lowering Medication: A Cohort Study |
| title_full_unstemmed | Lifestyle Changes in Relation to Initiation of Antihypertensive and Lipid‐Lowering Medication: A Cohort Study |
| title_short | Lifestyle Changes in Relation to Initiation of Antihypertensive and Lipid‐Lowering Medication: A Cohort Study |
| title_sort | lifestyle changes in relation to initiation of antihypertensive and lipid lowering medication a cohort study |
| topic | antihypertensive agents lifestyle longitudinal primary prevention statins |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.119.014168 |
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