CD49b Targeting Inhibits Tumor Growth and Boosts Anti-tumor Immunity

CD49b Targeting Inhibits Tumor Growth and Boosts Anti-tumor Immunity

The suppressive function of T-regulatory cells (Tregs) can have a detrimental effect on immune responses against tumor cells. Within the Treg cells subset, a new non-classical population has been reported, which expresses high levels of CD49b molecule and, depending on their activation status, can a...

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Bibliographic Details
Main Authors: Pamina Contreras-Kallens, Felipe Gálvez-Jirón, Javiera De Solminihac, Ahmed Elhusseiny, Wilfredo A. González-Arriagada, Francisca Alcayaga-Miranda, Randolph J. Noelle, Karina Pino-Lagos
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
Foxp3+ Treg
Tr1 cells
CD49b
tumor immunology
tolerance
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.928498/full

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