Remodeling the Bone Marrow Microenvironment – A Proposal for Targeting Pro-inflammatory Contributors in MPN
Philadelphia-negative myeloproliferative neoplasms (MPN) are malignant bone marrow (BM) disorders, typically arising from a single somatically mutated hematopoietic stem cell. The most commonly mutated genes, JAK2, CALR, and MPL lead to constitutively active JAK-STAT signaling. Common clinical featu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.02093/full |
| _version_ | 1818248939194810368 |
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| author | Jonas Samuel Jutzi Ann Mullally Ann Mullally Ann Mullally |
| author_facet | Jonas Samuel Jutzi Ann Mullally Ann Mullally Ann Mullally |
| author_sort | Jonas Samuel Jutzi |
| collection | DOAJ |
| description | Philadelphia-negative myeloproliferative neoplasms (MPN) are malignant bone marrow (BM) disorders, typically arising from a single somatically mutated hematopoietic stem cell. The most commonly mutated genes, JAK2, CALR, and MPL lead to constitutively active JAK-STAT signaling. Common clinical features include myeloproliferation, splenomegaly and constitutional symptoms. This review covers the contributions of cellular components of MPN pathology (e.g., monocytes, megakaryocytes, and mesenchymal stromal cells) as well as cytokines and soluble mediators to the development of myelofibrosis (MF) and highlights recent therapeutic advances. These findings outline the importance of malignant and non-malignant BM constituents to the pathogenesis and treatment of MF. |
| first_indexed | 2024-12-12T15:28:34Z |
| format | Article |
| id | doaj.art-fb8a6f5ca6ac424d8f436a3a791555cb |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T15:28:34Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-fb8a6f5ca6ac424d8f436a3a791555cb2022-12-22T00:20:10ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-08-011110.3389/fimmu.2020.02093561892Remodeling the Bone Marrow Microenvironment – A Proposal for Targeting Pro-inflammatory Contributors in MPNJonas Samuel Jutzi0Ann Mullally1Ann Mullally2Ann Mullally3Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesDivision of Hematology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United StatesCancer Program, Broad Institute, Cambridge, MA, United StatesPhiladelphia-negative myeloproliferative neoplasms (MPN) are malignant bone marrow (BM) disorders, typically arising from a single somatically mutated hematopoietic stem cell. The most commonly mutated genes, JAK2, CALR, and MPL lead to constitutively active JAK-STAT signaling. Common clinical features include myeloproliferation, splenomegaly and constitutional symptoms. This review covers the contributions of cellular components of MPN pathology (e.g., monocytes, megakaryocytes, and mesenchymal stromal cells) as well as cytokines and soluble mediators to the development of myelofibrosis (MF) and highlights recent therapeutic advances. These findings outline the importance of malignant and non-malignant BM constituents to the pathogenesis and treatment of MF.https://www.frontiersin.org/article/10.3389/fimmu.2020.02093/fullMPNJAK2CALRMPLinflammationmegakaryocytes |
| spellingShingle | Jonas Samuel Jutzi Ann Mullally Ann Mullally Ann Mullally Remodeling the Bone Marrow Microenvironment – A Proposal for Targeting Pro-inflammatory Contributors in MPN Frontiers in Immunology MPN JAK2 CALR MPL inflammation megakaryocytes |
| title | Remodeling the Bone Marrow Microenvironment – A Proposal for Targeting Pro-inflammatory Contributors in MPN |
| title_full | Remodeling the Bone Marrow Microenvironment – A Proposal for Targeting Pro-inflammatory Contributors in MPN |
| title_fullStr | Remodeling the Bone Marrow Microenvironment – A Proposal for Targeting Pro-inflammatory Contributors in MPN |
| title_full_unstemmed | Remodeling the Bone Marrow Microenvironment – A Proposal for Targeting Pro-inflammatory Contributors in MPN |
| title_short | Remodeling the Bone Marrow Microenvironment – A Proposal for Targeting Pro-inflammatory Contributors in MPN |
| title_sort | remodeling the bone marrow microenvironment a proposal for targeting pro inflammatory contributors in mpn |
| topic | MPN JAK2 CALR MPL inflammation megakaryocytes |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.02093/full |
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