Evaluating the translational value of postmortem brain reperfusion technology
A novel pulsatile-perfusion technology, dubbed BrainEx, has been shown to restore microcirculation and cellular functions in the pig brain, 4 h postmortem. This technology has generated enthusiasm for its translational value for human neuroresuscitation. I offer a critical analysis of the study and...
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| Format: | Article |
| Language: | English |
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De Gruyter
2021-07-01
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| Series: | Translational Neuroscience |
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| Online Access: | https://doi.org/10.1515/tnsci-2020-0179 |
| Summary: | A novel pulsatile-perfusion technology, dubbed BrainEx, has been shown to restore microcirculation and cellular functions in the pig brain, 4 h postmortem. This technology has generated enthusiasm for its translational value for human neuroresuscitation. I offer a critical analysis of the study and its methodology, providing several reasons for skepticism. This includes: all phenomena were observed at different degrees of hypothermia; the physiological and biochemical milieu of the experimental preparation is radically different than the clinical setting of hypoxic-ischemic brain injury; and the study is confounded by uncontrolled traumatic brain injury and lifelong stress in all the animals. |
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| ISSN: | 2081-6936 |