Evaluating the translational value of postmortem brain reperfusion technology
A novel pulsatile-perfusion technology, dubbed BrainEx, has been shown to restore microcirculation and cellular functions in the pig brain, 4 h postmortem. This technology has generated enthusiasm for its translational value for human neuroresuscitation. I offer a critical analysis of the study and...
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| Format: | Article |
| Language: | English |
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De Gruyter
2021-07-01
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| Series: | Translational Neuroscience |
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| Online Access: | https://doi.org/10.1515/tnsci-2020-0179 |
| _version_ | 1811280635237498880 |
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| author | Nair-Collins Michael |
| author_facet | Nair-Collins Michael |
| author_sort | Nair-Collins Michael |
| collection | DOAJ |
| description | A novel pulsatile-perfusion technology, dubbed BrainEx, has been shown to restore microcirculation and cellular functions in the pig brain, 4 h postmortem. This technology has generated enthusiasm for its translational value for human neuroresuscitation. I offer a critical analysis of the study and its methodology, providing several reasons for skepticism. This includes: all phenomena were observed at different degrees of hypothermia; the physiological and biochemical milieu of the experimental preparation is radically different than the clinical setting of hypoxic-ischemic brain injury; and the study is confounded by uncontrolled traumatic brain injury and lifelong stress in all the animals. |
| first_indexed | 2024-04-13T01:17:12Z |
| format | Article |
| id | doaj.art-fb8c985a767f4bff9adddf58d3ade423 |
| institution | Directory Open Access Journal |
| issn | 2081-6936 |
| language | English |
| last_indexed | 2024-04-13T01:17:12Z |
| publishDate | 2021-07-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Translational Neuroscience |
| spelling | doaj.art-fb8c985a767f4bff9adddf58d3ade4232022-12-22T03:08:52ZengDe GruyterTranslational Neuroscience2081-69362021-07-0112129730010.1515/tnsci-2020-0179Evaluating the translational value of postmortem brain reperfusion technologyNair-Collins Michael0Department of Behavioral Sciences and Social Medicine, Florida State University College of Medicine, Tallahassee, Florida, United States of AmericaA novel pulsatile-perfusion technology, dubbed BrainEx, has been shown to restore microcirculation and cellular functions in the pig brain, 4 h postmortem. This technology has generated enthusiasm for its translational value for human neuroresuscitation. I offer a critical analysis of the study and its methodology, providing several reasons for skepticism. This includes: all phenomena were observed at different degrees of hypothermia; the physiological and biochemical milieu of the experimental preparation is radically different than the clinical setting of hypoxic-ischemic brain injury; and the study is confounded by uncontrolled traumatic brain injury and lifelong stress in all the animals.https://doi.org/10.1515/tnsci-2020-0179brain ischemiabrain deathbrain perfusionsus scrofa domesticusneuroresuscitationneurorehabilitation |
| spellingShingle | Nair-Collins Michael Evaluating the translational value of postmortem brain reperfusion technology Translational Neuroscience brain ischemia brain death brain perfusion sus scrofa domesticus neuroresuscitation neurorehabilitation |
| title | Evaluating the translational value of postmortem brain reperfusion technology |
| title_full | Evaluating the translational value of postmortem brain reperfusion technology |
| title_fullStr | Evaluating the translational value of postmortem brain reperfusion technology |
| title_full_unstemmed | Evaluating the translational value of postmortem brain reperfusion technology |
| title_short | Evaluating the translational value of postmortem brain reperfusion technology |
| title_sort | evaluating the translational value of postmortem brain reperfusion technology |
| topic | brain ischemia brain death brain perfusion sus scrofa domesticus neuroresuscitation neurorehabilitation |
| url | https://doi.org/10.1515/tnsci-2020-0179 |
| work_keys_str_mv | AT naircollinsmichael evaluatingthetranslationalvalueofpostmortembrainreperfusiontechnology |