Enlarged perivascular spaces in patients with migraine: a case–control study based on 3T MRI
Abstract Objective To explore whether MRI‐visible enlarged perivascular spaces (EPVS) are associated with migraine and may serve as a predictor of migraine. Then further explore its correlation with migraine chronification. Methods A total of 231 participants (healthy control [HC] = 57, episodic mig...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-07-01
|
| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.51798 |
| _version_ | 1797778142702600192 |
|---|---|
| author | Ziyu Yuan Wei Li Hefei Tang Yanliang Mei Dong Qiu Min Zhang Qian Sun Wei Wang Peng Zhang Zhaochao Ma Xueyan Zhang Yaqing Zhang Yonggang Wang Xueying Yu |
| author_facet | Ziyu Yuan Wei Li Hefei Tang Yanliang Mei Dong Qiu Min Zhang Qian Sun Wei Wang Peng Zhang Zhaochao Ma Xueyan Zhang Yaqing Zhang Yonggang Wang Xueying Yu |
| author_sort | Ziyu Yuan |
| collection | DOAJ |
| description | Abstract Objective To explore whether MRI‐visible enlarged perivascular spaces (EPVS) are associated with migraine and may serve as a predictor of migraine. Then further explore its correlation with migraine chronification. Methods A total of 231 participants (healthy control [HC] = 57, episodic migraine [EM] = 59, chronic migraine [CM] = 115) were included in this case–control study. A 3T MRI device and the validated visual rating scale were used to assess the grades of EPVS in centrum semiovale (CSO), midbrain (MB), and basal ganglia (BG). Comparisons between the two groups were made using the chi‐square or Fisher's exact tests to initially determine whether high‐grade EPVS were associated with migraine and migraine chronification. A multivariate logistic regression model was constructed to further investigate the role of high‐grade EPVS in migraine. Results The prevalence of high‐grade EPVS in CSO and MB were significantly higher in patients with migraine than in HCs (CSO: 64.94% vs. 42.11%, P = 0.002; MB: 55.75% vs. 29.82%, P = 0.001). Subgroup analysis showed no statistical difference between patients with EM and CM (CSO: 69.94% vs. 62.61%, P = 0.368; MB: 50.85% vs. 58.26%, P = 0.351). Individuals with high‐grade EPVS in CSO (odds ratio [OR]: 2.324; 95% confidence interval [CI]: 1.136–4.754; P = 0.021) and MB (OR: 3.261; 95% CI: 1.534–6.935; P = 0.002) were more likely to suffer from migraine. Interpretation This case–control study showed that high‐grade EPVS in CSO and MB in clinical practice with the underlying mechanism of dysfunction of the glymphatic system could be a predictor of migraine, but no significant correlation had been found with migraine chronification. |
| first_indexed | 2024-03-12T23:14:03Z |
| format | Article |
| id | doaj.art-fb8d5945318a4c82ab2e93c2e4e9e42b |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-03-12T23:14:03Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-fb8d5945318a4c82ab2e93c2e4e9e42b2023-07-17T17:19:00ZengWileyAnnals of Clinical and Translational Neurology2328-95032023-07-011071160116910.1002/acn3.51798Enlarged perivascular spaces in patients with migraine: a case–control study based on 3T MRIZiyu Yuan0Wei Li1Hefei Tang2Yanliang Mei3Dong Qiu4Min Zhang5Qian Sun6Wei Wang7Peng Zhang8Zhaochao Ma9Xueyan Zhang10Yaqing Zhang11Yonggang Wang12Xueying Yu13Headache Center, Department of Neurology Beijing Tiantan Hospital, Capital Medical University Beijing ChinaDepartment of Neurology Fourth People's Hospital of Langfang Langfang ChinaHeadache Center, Department of Neurology Beijing Tiantan Hospital, Capital Medical University Beijing ChinaHeadache Center, Department of Neurology Beijing Tiantan Hospital, Capital Medical University Beijing ChinaHeadache Center, Department of Neurology Beijing Tiantan Hospital, Capital Medical University Beijing ChinaDepartment of Neurology Baotou Eighth Hospital Baotou ChinaDepartment of Neurology Xinxiang Central Hospital Xinxiang ChinaHeadache Center, Department of Neurology Beijing Tiantan Hospital, Capital Medical University Beijing ChinaHeadache Center, Department of Neurology Beijing Tiantan Hospital, Capital Medical University Beijing ChinaDepartment of Pharmacy Beijing Tiantan Hospital, Capital Medical University Beijing ChinaDepartment of Neurology The First Affiliated Hospital of Zhengzhou University Zhengzhou ChinaHeadache Center, Department of Neurology Beijing Tiantan Hospital, Capital Medical University Beijing ChinaHeadache Center, Department of Neurology Beijing Tiantan Hospital, Capital Medical University Beijing ChinaHeadache Center, Department of Neurology Beijing Tiantan Hospital, Capital Medical University Beijing ChinaAbstract Objective To explore whether MRI‐visible enlarged perivascular spaces (EPVS) are associated with migraine and may serve as a predictor of migraine. Then further explore its correlation with migraine chronification. Methods A total of 231 participants (healthy control [HC] = 57, episodic migraine [EM] = 59, chronic migraine [CM] = 115) were included in this case–control study. A 3T MRI device and the validated visual rating scale were used to assess the grades of EPVS in centrum semiovale (CSO), midbrain (MB), and basal ganglia (BG). Comparisons between the two groups were made using the chi‐square or Fisher's exact tests to initially determine whether high‐grade EPVS were associated with migraine and migraine chronification. A multivariate logistic regression model was constructed to further investigate the role of high‐grade EPVS in migraine. Results The prevalence of high‐grade EPVS in CSO and MB were significantly higher in patients with migraine than in HCs (CSO: 64.94% vs. 42.11%, P = 0.002; MB: 55.75% vs. 29.82%, P = 0.001). Subgroup analysis showed no statistical difference between patients with EM and CM (CSO: 69.94% vs. 62.61%, P = 0.368; MB: 50.85% vs. 58.26%, P = 0.351). Individuals with high‐grade EPVS in CSO (odds ratio [OR]: 2.324; 95% confidence interval [CI]: 1.136–4.754; P = 0.021) and MB (OR: 3.261; 95% CI: 1.534–6.935; P = 0.002) were more likely to suffer from migraine. Interpretation This case–control study showed that high‐grade EPVS in CSO and MB in clinical practice with the underlying mechanism of dysfunction of the glymphatic system could be a predictor of migraine, but no significant correlation had been found with migraine chronification.https://doi.org/10.1002/acn3.51798 |
| spellingShingle | Ziyu Yuan Wei Li Hefei Tang Yanliang Mei Dong Qiu Min Zhang Qian Sun Wei Wang Peng Zhang Zhaochao Ma Xueyan Zhang Yaqing Zhang Yonggang Wang Xueying Yu Enlarged perivascular spaces in patients with migraine: a case–control study based on 3T MRI Annals of Clinical and Translational Neurology |
| title | Enlarged perivascular spaces in patients with migraine: a case–control study based on 3T MRI |
| title_full | Enlarged perivascular spaces in patients with migraine: a case–control study based on 3T MRI |
| title_fullStr | Enlarged perivascular spaces in patients with migraine: a case–control study based on 3T MRI |
| title_full_unstemmed | Enlarged perivascular spaces in patients with migraine: a case–control study based on 3T MRI |
| title_short | Enlarged perivascular spaces in patients with migraine: a case–control study based on 3T MRI |
| title_sort | enlarged perivascular spaces in patients with migraine a case control study based on 3t mri |
| url | https://doi.org/10.1002/acn3.51798 |
| work_keys_str_mv | AT ziyuyuan enlargedperivascularspacesinpatientswithmigraineacasecontrolstudybasedon3tmri AT weili enlargedperivascularspacesinpatientswithmigraineacasecontrolstudybasedon3tmri AT hefeitang enlargedperivascularspacesinpatientswithmigraineacasecontrolstudybasedon3tmri AT yanliangmei enlargedperivascularspacesinpatientswithmigraineacasecontrolstudybasedon3tmri AT dongqiu enlargedperivascularspacesinpatientswithmigraineacasecontrolstudybasedon3tmri AT minzhang enlargedperivascularspacesinpatientswithmigraineacasecontrolstudybasedon3tmri AT qiansun enlargedperivascularspacesinpatientswithmigraineacasecontrolstudybasedon3tmri AT weiwang enlargedperivascularspacesinpatientswithmigraineacasecontrolstudybasedon3tmri AT pengzhang enlargedperivascularspacesinpatientswithmigraineacasecontrolstudybasedon3tmri AT zhaochaoma enlargedperivascularspacesinpatientswithmigraineacasecontrolstudybasedon3tmri AT xueyanzhang enlargedperivascularspacesinpatientswithmigraineacasecontrolstudybasedon3tmri AT yaqingzhang enlargedperivascularspacesinpatientswithmigraineacasecontrolstudybasedon3tmri AT yonggangwang enlargedperivascularspacesinpatientswithmigraineacasecontrolstudybasedon3tmri AT xueyingyu enlargedperivascularspacesinpatientswithmigraineacasecontrolstudybasedon3tmri |