Heat Shock Protein 70 and CHIP Promote Nox4 Ubiquitination and Degradation within the Losartan Antioxidative Effect in Proximal Tubule Cells

Heat Shock Protein 70 and CHIP Promote Nox4 Ubiquitination and Degradation within the Losartan Antioxidative Effect in Proximal Tubule Cells

Background: Angiotensin II/Angiotensin II type 1 receptor (AT1R) effects are dependent on ROS production stimulated by NADPH oxidase activation. Hsp70 regulates a diverse set of signaling pathways through their interactions with proteins. CHIP is a E3 ubiquitin ligase that targets proteins for polyu...

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Bibliographic Details
Main Authors: Andrea F. Gil Lorenzo, Valeria V. Costantino, Martin López Appiolaza, Valeria Cacciamani, Maria E. Benardon, Victoria Bocanegra, Patricia G. Vallés
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Proximal tubule cells
Angiotensin II
Losartan
Nox4/Hsp70/CHIP
Ubiquitination
Online Access:http://www.karger.com/Article/FullText/430184

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