Performance evaluation of maize starch as a multifunctional excipient in metronidazole tablet formulation
ABSTRACT Objective: The aim of this study was to evaluate the performance of maize starch as a multifunctional excipient in metronidazole tablet formulation. Methods: Metronidazole tablets were prepared by wet granulation containing maize starch as diluent (40 %), disintegrant (10 %), and binder (...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Facultad de Farmacia, Universidad de Granada
2020-03-01
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| Series: | Ars Pharmaceutica |
| Subjects: | |
| Online Access: | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S2340-98942019000500004&tlng=en |
| _version_ | 1798033273908101120 |
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| author | Yonni Eshovo Apeji Ali Abdulhakim Sophie Nock Anyebe Oluwaseun Adenike Orugun Adeniji Kehinde Olowosulu Avosuahi Rukayat Oyi |
| author_facet | Yonni Eshovo Apeji Ali Abdulhakim Sophie Nock Anyebe Oluwaseun Adenike Orugun Adeniji Kehinde Olowosulu Avosuahi Rukayat Oyi |
| author_sort | Yonni Eshovo Apeji |
| collection | DOAJ |
| description | ABSTRACT Objective: The aim of this study was to evaluate the performance of maize starch as a multifunctional excipient in metronidazole tablet formulation. Methods: Metronidazole tablets were prepared by wet granulation containing maize starch as diluent (40 %), disintegrant (10 %), and binder (5 %) and compared with a reference formulation containing lactose as diluent (40 %), maize starch as disintegrant (10 %) and acacia as binder (5 %). The granules were analysed for particle size, flow properties, compressibility and moisture content. Tablets weighing 500 mg were compressed for both formulations on a Single Punch Tablet Press using a 12 mm flat-faced punches at 57.5 MPa. The tablets were kept for 24 h to allow for elastic recovery and evaluated for weight and content uniformity, thickness, crushing strength, friability, disintegration time and in vitro drug release. Results: The granule properties revealed differences in mean granule size, angle of repose, bulk and tapped densities for both formulations. Batch I tablets gave rise to better tableting properties compared to batch II tablets. Conclusion: This study confirms the suitability of maize starch as a multifunctional excipient in tablet formulation. |
| first_indexed | 2024-04-11T20:27:42Z |
| format | Article |
| id | doaj.art-fb9025a3cbdc43ffbae24faf165df5a7 |
| institution | Directory Open Access Journal |
| issn | 2340-9894 |
| language | English |
| last_indexed | 2024-04-11T20:27:42Z |
| publishDate | 2020-03-01 |
| publisher | Facultad de Farmacia, Universidad de Granada |
| record_format | Article |
| series | Ars Pharmaceutica |
| spelling | doaj.art-fb9025a3cbdc43ffbae24faf165df5a72022-12-22T04:04:37ZengFacultad de Farmacia, Universidad de GranadaArs Pharmaceutica2340-98942020-03-0160316116710.30827/ars.v60i3.9289Performance evaluation of maize starch as a multifunctional excipient in metronidazole tablet formulationYonni Eshovo ApejiAli AbdulhakimSophie Nock AnyebeOluwaseun Adenike OrugunAdeniji Kehinde OlowosuluAvosuahi Rukayat OyiABSTRACT Objective: The aim of this study was to evaluate the performance of maize starch as a multifunctional excipient in metronidazole tablet formulation. Methods: Metronidazole tablets were prepared by wet granulation containing maize starch as diluent (40 %), disintegrant (10 %), and binder (5 %) and compared with a reference formulation containing lactose as diluent (40 %), maize starch as disintegrant (10 %) and acacia as binder (5 %). The granules were analysed for particle size, flow properties, compressibility and moisture content. Tablets weighing 500 mg were compressed for both formulations on a Single Punch Tablet Press using a 12 mm flat-faced punches at 57.5 MPa. The tablets were kept for 24 h to allow for elastic recovery and evaluated for weight and content uniformity, thickness, crushing strength, friability, disintegration time and in vitro drug release. Results: The granule properties revealed differences in mean granule size, angle of repose, bulk and tapped densities for both formulations. Batch I tablets gave rise to better tableting properties compared to batch II tablets. Conclusion: This study confirms the suitability of maize starch as a multifunctional excipient in tablet formulation.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S2340-98942019000500004&tlng=enMaize starchmultifunctional excipientgranulestableting |
| spellingShingle | Yonni Eshovo Apeji Ali Abdulhakim Sophie Nock Anyebe Oluwaseun Adenike Orugun Adeniji Kehinde Olowosulu Avosuahi Rukayat Oyi Performance evaluation of maize starch as a multifunctional excipient in metronidazole tablet formulation Ars Pharmaceutica Maize starch multifunctional excipient granules tableting |
| title | Performance evaluation of maize starch as a multifunctional excipient in metronidazole tablet formulation |
| title_full | Performance evaluation of maize starch as a multifunctional excipient in metronidazole tablet formulation |
| title_fullStr | Performance evaluation of maize starch as a multifunctional excipient in metronidazole tablet formulation |
| title_full_unstemmed | Performance evaluation of maize starch as a multifunctional excipient in metronidazole tablet formulation |
| title_short | Performance evaluation of maize starch as a multifunctional excipient in metronidazole tablet formulation |
| title_sort | performance evaluation of maize starch as a multifunctional excipient in metronidazole tablet formulation |
| topic | Maize starch multifunctional excipient granules tableting |
| url | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S2340-98942019000500004&tlng=en |
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