Clinical characteristics and classification of Cameroonians with obesity and metabolically normal phenotype in the West region of Cameroon
The objective of this study was to classify and suggest an adequate definition of the metabolically normal phenotype among Cameroonians with obesity in the western Region of Cameroon. A cross-sectional study was conducted in the West Cameroon Region from August 2016 to August 2017. A total of 324 su...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844022029401 |
| _version_ | 1811213804537643008 |
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| author | Maxwell Wandji Nguedjo Judith Laure Ngondi Françoise Raïssa Ntentie Boris Gabin Kingue Azantsa Javeres Leonel Ntepe Mbah Julius Enyong Oben |
| author_facet | Maxwell Wandji Nguedjo Judith Laure Ngondi Françoise Raïssa Ntentie Boris Gabin Kingue Azantsa Javeres Leonel Ntepe Mbah Julius Enyong Oben |
| author_sort | Maxwell Wandji Nguedjo |
| collection | DOAJ |
| description | The objective of this study was to classify and suggest an adequate definition of the metabolically normal phenotype among Cameroonians with obesity in the western Region of Cameroon. A cross-sectional study was conducted in the West Cameroon Region from August 2016 to August 2017. A total of 324 subjects with BMI >27 kg/m2, aged of 20 years and older, and not treated for cardiometabolic diseases were included in the study. Sociodemographic and clinical parameters of the subjects were collected. Four definitions of metabolic status were tested to suggest the definition that best identifies the subjects with obesity but metabolically normal phenotype (MNO) in the study. The prevalence of the MNO phenotype varied from 2.50% to 29.60% according to the definitions used. According to the individual definitions, the prevalence of the MNO phenotype was 29.60% according to Hinnouho, 16.00% according to Mbanya, 7.40% according to Meigs and 2.50% according to Widman. Markers of inflammatory profile (high sensitivity C-reactive protein and tumor necrosis factor-alpha), carbohydrate homeostasis (fasting glucose and homeostasis model assessment), markers of lipid profile (total cholesterol and triglyceride), systolic blood pressure, nitric oxide, adiposity indices (Waist circumference and waist to hip ratio) were significantly lower in MNO subjects for the majority of definitions (p < 0.05). The modified Hinnouho definition showed better specificity (60.90%) and sensitivity (12.10%) for an area under the ROC curve of 0.98. The degree of agreement was low between the different pairs of definition of the MNO phenotype (Kappa< 0.61). There is poor agreement between the different definitions of the MNO phenotype among Cameroonians with obesity. Therefore, the adoption of a universal definition of MNO phenotype should be proposed to facilitate the management of metabolic health in people with obesity. |
| first_indexed | 2024-04-12T05:52:21Z |
| format | Article |
| id | doaj.art-fb905115b5e344f8afbfdf8dd087e3f0 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-12T05:52:21Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-fb905115b5e344f8afbfdf8dd087e3f02022-12-22T03:45:17ZengElsevierHeliyon2405-84402022-11-01811e11652Clinical characteristics and classification of Cameroonians with obesity and metabolically normal phenotype in the West region of CameroonMaxwell Wandji Nguedjo0Judith Laure Ngondi1Françoise Raïssa Ntentie2Boris Gabin Kingue Azantsa3Javeres Leonel Ntepe Mbah4Julius Enyong Oben5Department of Biochemistry, Faculty of Sciences, University of Yaounde 1, P. O. Box 812, Yaounde, Cameroon; Centre for Food, Food Security and Nutrition Research, Institute of Medical Research and Medicinal Plant Studies, P. O. Box 13033, Yaounde, CameroonDepartment of Biochemistry, Faculty of Sciences, University of Yaounde 1, P. O. Box 812, Yaounde, Cameroon; Corresponding author.Higher Teacher's and Training College, University of Maroua, P. O. Box 55, Maroua, CameroonDepartment of Biochemistry, Faculty of Sciences, University of Yaounde 1, P. O. Box 812, Yaounde, CameroonLaboratory of Human Metabolism and Non-Communicable Disease, Institute of Medical Research and Medicinal Plant Studies, P. O. Box 13033, Yaounde, Cameroon; Department of Biosciences, COMSATS University Islamabad, Chak Shahzad, Islamabad 45550, PakistanDepartment of Biochemistry, Faculty of Sciences, University of Yaounde 1, P. O. Box 812, Yaounde, CameroonThe objective of this study was to classify and suggest an adequate definition of the metabolically normal phenotype among Cameroonians with obesity in the western Region of Cameroon. A cross-sectional study was conducted in the West Cameroon Region from August 2016 to August 2017. A total of 324 subjects with BMI >27 kg/m2, aged of 20 years and older, and not treated for cardiometabolic diseases were included in the study. Sociodemographic and clinical parameters of the subjects were collected. Four definitions of metabolic status were tested to suggest the definition that best identifies the subjects with obesity but metabolically normal phenotype (MNO) in the study. The prevalence of the MNO phenotype varied from 2.50% to 29.60% according to the definitions used. According to the individual definitions, the prevalence of the MNO phenotype was 29.60% according to Hinnouho, 16.00% according to Mbanya, 7.40% according to Meigs and 2.50% according to Widman. Markers of inflammatory profile (high sensitivity C-reactive protein and tumor necrosis factor-alpha), carbohydrate homeostasis (fasting glucose and homeostasis model assessment), markers of lipid profile (total cholesterol and triglyceride), systolic blood pressure, nitric oxide, adiposity indices (Waist circumference and waist to hip ratio) were significantly lower in MNO subjects for the majority of definitions (p < 0.05). The modified Hinnouho definition showed better specificity (60.90%) and sensitivity (12.10%) for an area under the ROC curve of 0.98. The degree of agreement was low between the different pairs of definition of the MNO phenotype (Kappa< 0.61). There is poor agreement between the different definitions of the MNO phenotype among Cameroonians with obesity. Therefore, the adoption of a universal definition of MNO phenotype should be proposed to facilitate the management of metabolic health in people with obesity.http://www.sciencedirect.com/science/article/pii/S2405844022029401ObesityMetabolically normal phenotypeClinical characteristicsClassification |
| spellingShingle | Maxwell Wandji Nguedjo Judith Laure Ngondi Françoise Raïssa Ntentie Boris Gabin Kingue Azantsa Javeres Leonel Ntepe Mbah Julius Enyong Oben Clinical characteristics and classification of Cameroonians with obesity and metabolically normal phenotype in the West region of Cameroon Heliyon Obesity Metabolically normal phenotype Clinical characteristics Classification |
| title | Clinical characteristics and classification of Cameroonians with obesity and metabolically normal phenotype in the West region of Cameroon |
| title_full | Clinical characteristics and classification of Cameroonians with obesity and metabolically normal phenotype in the West region of Cameroon |
| title_fullStr | Clinical characteristics and classification of Cameroonians with obesity and metabolically normal phenotype in the West region of Cameroon |
| title_full_unstemmed | Clinical characteristics and classification of Cameroonians with obesity and metabolically normal phenotype in the West region of Cameroon |
| title_short | Clinical characteristics and classification of Cameroonians with obesity and metabolically normal phenotype in the West region of Cameroon |
| title_sort | clinical characteristics and classification of cameroonians with obesity and metabolically normal phenotype in the west region of cameroon |
| topic | Obesity Metabolically normal phenotype Clinical characteristics Classification |
| url | http://www.sciencedirect.com/science/article/pii/S2405844022029401 |
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