Autonomous device for application in late-phase hemorrhagic shock prevention.
Hemorrhagic shock (HS) is the leading cause of death for people with traumatic injuries. The onset of HS is correlated with marked changes in the plasma vasopressin levels and some studies indicate that administrating vasopressin in the bloodstream can help stabilize the situation. This situation ca...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3933680?pdf=render |
| _version_ | 1811209718914351104 |
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| author | Vlad Oncescu Seoho Lee Abdurrahman Gumus Kolbeinn Karlsson David Erickson |
| author_facet | Vlad Oncescu Seoho Lee Abdurrahman Gumus Kolbeinn Karlsson David Erickson |
| author_sort | Vlad Oncescu |
| collection | DOAJ |
| description | Hemorrhagic shock (HS) is the leading cause of death for people with traumatic injuries. The onset of HS is correlated with marked changes in the plasma vasopressin levels and some studies indicate that administrating vasopressin in the bloodstream can help stabilize the situation. This situation calls naturally for the use of implantable devices for both the monitoring and treatment of HS. In this work, we present a self-powered hemorrhagic-shock autonomous integrated device (hemoAID) that continuously monitors vasopressin levels and releases vasopressin automatically when levels drop below a certain threshold. We demonstrate that the device can operate at physiological concentrations of vasopressin, in sheep serum, thus paving the way towards the development of an autonomous implantable device for HS prevention. |
| first_indexed | 2024-04-12T04:45:18Z |
| format | Article |
| id | doaj.art-fb90c17e899b4875975ddd9c0cdb6236 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T04:45:18Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-fb90c17e899b4875975ddd9c0cdb62362022-12-22T03:47:32ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0192e8990310.1371/journal.pone.0089903Autonomous device for application in late-phase hemorrhagic shock prevention.Vlad OncescuSeoho LeeAbdurrahman GumusKolbeinn KarlssonDavid EricksonHemorrhagic shock (HS) is the leading cause of death for people with traumatic injuries. The onset of HS is correlated with marked changes in the plasma vasopressin levels and some studies indicate that administrating vasopressin in the bloodstream can help stabilize the situation. This situation calls naturally for the use of implantable devices for both the monitoring and treatment of HS. In this work, we present a self-powered hemorrhagic-shock autonomous integrated device (hemoAID) that continuously monitors vasopressin levels and releases vasopressin automatically when levels drop below a certain threshold. We demonstrate that the device can operate at physiological concentrations of vasopressin, in sheep serum, thus paving the way towards the development of an autonomous implantable device for HS prevention.http://europepmc.org/articles/PMC3933680?pdf=render |
| spellingShingle | Vlad Oncescu Seoho Lee Abdurrahman Gumus Kolbeinn Karlsson David Erickson Autonomous device for application in late-phase hemorrhagic shock prevention. PLoS ONE |
| title | Autonomous device for application in late-phase hemorrhagic shock prevention. |
| title_full | Autonomous device for application in late-phase hemorrhagic shock prevention. |
| title_fullStr | Autonomous device for application in late-phase hemorrhagic shock prevention. |
| title_full_unstemmed | Autonomous device for application in late-phase hemorrhagic shock prevention. |
| title_short | Autonomous device for application in late-phase hemorrhagic shock prevention. |
| title_sort | autonomous device for application in late phase hemorrhagic shock prevention |
| url | http://europepmc.org/articles/PMC3933680?pdf=render |
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