Saturated Fatty Acid Activates T Cell Inflammation Through a Nicotinamide Nucleotide Transhydrogenase (NNT)-Dependent Mechanism

Saturated Fatty Acid Activates T Cell Inflammation Through a Nicotinamide Nucleotide Transhydrogenase (NNT)-Dependent Mechanism

Circulating fatty acids (FAs) increase with obesity and can drive mitochondrial damage and inflammation. Nicotinamide nucleotide transhydrogenase (NNT) is a mitochondrial protein that positively regulates nicotinamide adenine dinucleotide phosphate (NADPH), a key mediator of energy transduction and...

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Bibliographic Details
Main Authors:	Grace McCambridge, Madhur Agrawal, Alanna Keady, Philip A. Kern, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath
Format:	Article
Language:	English
Published:	MDPI AG 2019-02-01
Series:	Biomolecules
Subjects:	mitochondria nicotinamide nucleotide transhydrogenase oleate palmitate peripheral blood mononuclear cells, reactive oxygen species, Th17 cytokines
Online Access:	https://www.mdpi.com/2218-273X/9/2/79

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