Potential salivary and serum biomarkers for burning mouth syndrome and their relationship with anxiety/depression
Background/purpose: The pathophysiology of burning mouth syndrome (BMS), although considered a multifactorial etiology including psychological factors, is still not well understood. Hence, this study aimed to investigate the potential usage of salivary and serum biomarkers, including brain-derived n...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Journal of Dental Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1991790223001782 |
| _version_ | 1797221872302030848 |
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| author | Ying Zhang Sai Ye Yangqing Zhang Hong Sun Xiaoxian Zhao Xuemin Shen Lan Wu |
| author_facet | Ying Zhang Sai Ye Yangqing Zhang Hong Sun Xiaoxian Zhao Xuemin Shen Lan Wu |
| author_sort | Ying Zhang |
| collection | DOAJ |
| description | Background/purpose: The pathophysiology of burning mouth syndrome (BMS), although considered a multifactorial etiology including psychological factors, is still not well understood. Hence, this study aimed to investigate the potential usage of salivary and serum biomarkers, including brain-derived neurotrophic factor (BDNF), interferon-gamma (IFN-γ), interleukin-1beta (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-alpha (TNF-α), in diagnosing BMS and their correlations with anxiety/depression. Materials and methods: 45 BMS patients and 14 healthy volunteers were enrolled. The patients were divided into BMS with anxiety/depression group and BMS without anxiety/depression group according to the scores of the Zung Self-rating Anxiety Scale (SAS) and Zung Self-rating Depression Scale (SDS). Additionally, concentrations of BDNF, IFN-γ, IL-1β, IL-6, IL-8, and TNF-α in saliva and those in serum among the patients and healthy volunteers were assessed by multiplex assay using Luminex 200TM system and Enzyme-linked immunosorbent assay (ELISA), respectively. Results: Among all the serum biomarkers, only BDNF showed a statistically significant decrease in the patients than the healthy volunteers (P < 0.05). Regarding saliva biomarkers, BDNF, IL-1β, and IL-8 all exhibited a statistically significant increase in all the BMS patients versus the healthy volunteers (P < 0.05) but only BDNF was significantly different between patients with anxiety/depression and healthy individuals when considering anxiety/depression. Among BMS patients with anxiety/depression, saliva TNF-α had positive associations with other biomarkers including BDNF, IFN-γ, IL-1β, IL-6, and IL-8 (P < 0.05). Conclusion: The increased concentration of saliva BDNF holds strong potential for diagnosing BMS and the elevated level of saliva TNF-α is crucial in identifying BMS patients with anxiety/depression. |
| first_indexed | 2024-04-24T13:12:20Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1991-7902 |
| language | English |
| last_indexed | 2024-04-24T13:12:20Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Dental Sciences |
| spelling | doaj.art-fb9270047ad4459287b93752dae33d152024-04-05T04:40:12ZengElsevierJournal of Dental Sciences1991-79022024-04-0119210521060Potential salivary and serum biomarkers for burning mouth syndrome and their relationship with anxiety/depressionYing Zhang0Sai Ye1Yangqing Zhang2Hong Sun3Xiaoxian Zhao4Xuemin Shen5Lan Wu6Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology, College of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology, College of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Jiao Tong University, Shanghai, ChinaNo.2 High School of East China Normal University, Shanghai, ChinaDepartment of Laboratory Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology, College of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology, College of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Jiao Tong University, Shanghai, China; Corresponding author. Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, 500 Quxi Road, Shanghai, 200011, China.Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology, College of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Jiao Tong University, Shanghai, China; Corresponding author. Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, 500 Quxi Road, Shanghai, 200011, China.Background/purpose: The pathophysiology of burning mouth syndrome (BMS), although considered a multifactorial etiology including psychological factors, is still not well understood. Hence, this study aimed to investigate the potential usage of salivary and serum biomarkers, including brain-derived neurotrophic factor (BDNF), interferon-gamma (IFN-γ), interleukin-1beta (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-alpha (TNF-α), in diagnosing BMS and their correlations with anxiety/depression. Materials and methods: 45 BMS patients and 14 healthy volunteers were enrolled. The patients were divided into BMS with anxiety/depression group and BMS without anxiety/depression group according to the scores of the Zung Self-rating Anxiety Scale (SAS) and Zung Self-rating Depression Scale (SDS). Additionally, concentrations of BDNF, IFN-γ, IL-1β, IL-6, IL-8, and TNF-α in saliva and those in serum among the patients and healthy volunteers were assessed by multiplex assay using Luminex 200TM system and Enzyme-linked immunosorbent assay (ELISA), respectively. Results: Among all the serum biomarkers, only BDNF showed a statistically significant decrease in the patients than the healthy volunteers (P < 0.05). Regarding saliva biomarkers, BDNF, IL-1β, and IL-8 all exhibited a statistically significant increase in all the BMS patients versus the healthy volunteers (P < 0.05) but only BDNF was significantly different between patients with anxiety/depression and healthy individuals when considering anxiety/depression. Among BMS patients with anxiety/depression, saliva TNF-α had positive associations with other biomarkers including BDNF, IFN-γ, IL-1β, IL-6, and IL-8 (P < 0.05). Conclusion: The increased concentration of saliva BDNF holds strong potential for diagnosing BMS and the elevated level of saliva TNF-α is crucial in identifying BMS patients with anxiety/depression.http://www.sciencedirect.com/science/article/pii/S1991790223001782AnxietyBiomarkersBurning mouth syndromeDepressionSalivaSerum |
| spellingShingle | Ying Zhang Sai Ye Yangqing Zhang Hong Sun Xiaoxian Zhao Xuemin Shen Lan Wu Potential salivary and serum biomarkers for burning mouth syndrome and their relationship with anxiety/depression Journal of Dental Sciences Anxiety Biomarkers Burning mouth syndrome Depression Saliva Serum |
| title | Potential salivary and serum biomarkers for burning mouth syndrome and their relationship with anxiety/depression |
| title_full | Potential salivary and serum biomarkers for burning mouth syndrome and their relationship with anxiety/depression |
| title_fullStr | Potential salivary and serum biomarkers for burning mouth syndrome and their relationship with anxiety/depression |
| title_full_unstemmed | Potential salivary and serum biomarkers for burning mouth syndrome and their relationship with anxiety/depression |
| title_short | Potential salivary and serum biomarkers for burning mouth syndrome and their relationship with anxiety/depression |
| title_sort | potential salivary and serum biomarkers for burning mouth syndrome and their relationship with anxiety depression |
| topic | Anxiety Biomarkers Burning mouth syndrome Depression Saliva Serum |
| url | http://www.sciencedirect.com/science/article/pii/S1991790223001782 |
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