Randomly fluctuating neural connections may implement a consolidation mechanism that explains classic memory laws
Abstract How can we reconcile the massive fluctuations in neural connections with a stable long-term memory? Two-photon microscopy studies have revealed that large portions of neural connections (spines, synapses) are unexpectedly active, changing unpredictably over time. This appears to invalidate...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-17639-5 |
| _version_ | 1817968104428273664 |
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| author | Jaap M. J. Murre |
| author_facet | Jaap M. J. Murre |
| author_sort | Jaap M. J. Murre |
| collection | DOAJ |
| description | Abstract How can we reconcile the massive fluctuations in neural connections with a stable long-term memory? Two-photon microscopy studies have revealed that large portions of neural connections (spines, synapses) are unexpectedly active, changing unpredictably over time. This appears to invalidate the main assumption underlying the majority of memory models in cognitive neuroscience, which rely on stable connections that retain information over time. Here, we show that such random fluctuations may in fact implement a type of memory consolidation mechanism with a stable very long-term memory that offers novel explanations for several classic memory ‘laws’, namely Jost’s Law (1897: superiority of spaced learning) and Ribot’s Law (1881: loss of recent memories in retrograde amnesia), for which a common neural basis has been postulated but not established, as well as other general ‘laws’ of learning and forgetting. We show how these phenomena emerge naturally from massively fluctuating neural connections. |
| first_indexed | 2024-04-13T20:03:35Z |
| format | Article |
| id | doaj.art-fb92e3866c9e469fa71646e7e323b8d3 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T20:03:35Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-fb92e3866c9e469fa71646e7e323b8d32022-12-22T02:32:07ZengNature PortfolioScientific Reports2045-23222022-08-011211810.1038/s41598-022-17639-5Randomly fluctuating neural connections may implement a consolidation mechanism that explains classic memory lawsJaap M. J. Murre0Brain and Cognition Unit, Psychology Department, University of AmsterdamAbstract How can we reconcile the massive fluctuations in neural connections with a stable long-term memory? Two-photon microscopy studies have revealed that large portions of neural connections (spines, synapses) are unexpectedly active, changing unpredictably over time. This appears to invalidate the main assumption underlying the majority of memory models in cognitive neuroscience, which rely on stable connections that retain information over time. Here, we show that such random fluctuations may in fact implement a type of memory consolidation mechanism with a stable very long-term memory that offers novel explanations for several classic memory ‘laws’, namely Jost’s Law (1897: superiority of spaced learning) and Ribot’s Law (1881: loss of recent memories in retrograde amnesia), for which a common neural basis has been postulated but not established, as well as other general ‘laws’ of learning and forgetting. We show how these phenomena emerge naturally from massively fluctuating neural connections.https://doi.org/10.1038/s41598-022-17639-5 |
| spellingShingle | Jaap M. J. Murre Randomly fluctuating neural connections may implement a consolidation mechanism that explains classic memory laws Scientific Reports |
| title | Randomly fluctuating neural connections may implement a consolidation mechanism that explains classic memory laws |
| title_full | Randomly fluctuating neural connections may implement a consolidation mechanism that explains classic memory laws |
| title_fullStr | Randomly fluctuating neural connections may implement a consolidation mechanism that explains classic memory laws |
| title_full_unstemmed | Randomly fluctuating neural connections may implement a consolidation mechanism that explains classic memory laws |
| title_short | Randomly fluctuating neural connections may implement a consolidation mechanism that explains classic memory laws |
| title_sort | randomly fluctuating neural connections may implement a consolidation mechanism that explains classic memory laws |
| url | https://doi.org/10.1038/s41598-022-17639-5 |
| work_keys_str_mv | AT jaapmjmurre randomlyfluctuatingneuralconnectionsmayimplementaconsolidationmechanismthatexplainsclassicmemorylaws |