Effects of Long-Term Selection in the Border Collie Dog Breed: Inbreeding Purge of Canine Hip and Elbow Dysplasia
Pedigree data of 13,339 border collie dog was collected along with canine hip dysplasia (CHD) and canine elbow dysplasia (CED) records (1352 CHD and 524 CED), and an inbreeding–purging (IP) model was created. Ancestral inbreeding coefficients were calculated by using a gene dropping simulation metho...
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| Format: | Article |
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MDPI AG
2020-09-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/10/10/1743 |
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| author | Virág Ács György Kövér János Farkas Árpád Bokor István Nagy |
| author_facet | Virág Ács György Kövér János Farkas Árpád Bokor István Nagy |
| author_sort | Virág Ács |
| collection | DOAJ |
| description | Pedigree data of 13,339 border collie dog was collected along with canine hip dysplasia (CHD) and canine elbow dysplasia (CED) records (1352 CHD and 524 CED), and an inbreeding–purging (IP) model was created. Ancestral inbreeding coefficients were calculated by using a gene dropping simulation method with GRain 2.2 software. Cumulative logit models (CLM) for CHD and CED were fitted using a logit-link Poisson distribution and the classical (F_<sub>W</sub>), and ancestral inbreeding (F_<sub>BAL</sub>, F_<sub>KAL</sub>, and F_<sub>KAL_NEW</sub>) coefficients as linear regression coefficients. The effective population size was calculated from F_<sub>W</sub> and decreased in the examined period along with an increase of F_<sub>W</sub>; however, slight differences were found as a consequence of breeding dog imports. CHD values were lowered by the expansion of F_<sub>BAL</sub>, as the alleles had been inbred in the past. For CHD, signs of purging were obtained. There was a positive trend regarding the breeding activity (both sire and dam of the future litters should be screened and certified free from CHD and CED), as years of selection increased the frequency of alleles with favorable hip and elbow conformation. Division of the ancestral inbreeding coefficient showed that alleles that had been identical by descent (IBD) for the first time (F_<sub>KAL_NEW</sub>) had a negative effect on both traits, while F_<sub>KAL</sub> has shown favorable results for alleles IBD in past generations. Some authors had proven this phenomenon in captive populations or experimental conditions; however, no evidence of inbreeding purge has ever been described in dog populations. Despite the various breeding practices, it seems that alleles of these polygenic disorders could be successfully purged out of the population with long-term selection. |
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| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T16:03:17Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-fb94d3b0b7234381974de3a5a8c440582023-11-20T15:06:35ZengMDPI AGAnimals2076-26152020-09-011010174310.3390/ani10101743Effects of Long-Term Selection in the Border Collie Dog Breed: Inbreeding Purge of Canine Hip and Elbow DysplasiaVirág Ács0György Kövér1János Farkas2Árpád Bokor3István Nagy4Department of Animal Nutrition, Szent István University Kaposvár Campus, 40, Guba S. str., H-7400 Kaposvár, HungaryDepartment of Mathematics and Informatics, Szent István University Kaposvár Campus, 40, Guba S. str., H-7400 Kaposvár, HungaryDepartment of Mathematics and Informatics, Szent István University Kaposvár Campus, 40, Guba S. str., H-7400 Kaposvár, HungaryDepartment of Hippology, Szent István University Kaposvár Campus, 40, Guba S. str., H-7400 Kaposvár, HungaryDepartment of Animal Science, Szent István University Kaposvár Campus, 40, Guba S. str., H-7400 Kaposvár, HungaryPedigree data of 13,339 border collie dog was collected along with canine hip dysplasia (CHD) and canine elbow dysplasia (CED) records (1352 CHD and 524 CED), and an inbreeding–purging (IP) model was created. Ancestral inbreeding coefficients were calculated by using a gene dropping simulation method with GRain 2.2 software. Cumulative logit models (CLM) for CHD and CED were fitted using a logit-link Poisson distribution and the classical (F_<sub>W</sub>), and ancestral inbreeding (F_<sub>BAL</sub>, F_<sub>KAL</sub>, and F_<sub>KAL_NEW</sub>) coefficients as linear regression coefficients. The effective population size was calculated from F_<sub>W</sub> and decreased in the examined period along with an increase of F_<sub>W</sub>; however, slight differences were found as a consequence of breeding dog imports. CHD values were lowered by the expansion of F_<sub>BAL</sub>, as the alleles had been inbred in the past. For CHD, signs of purging were obtained. There was a positive trend regarding the breeding activity (both sire and dam of the future litters should be screened and certified free from CHD and CED), as years of selection increased the frequency of alleles with favorable hip and elbow conformation. Division of the ancestral inbreeding coefficient showed that alleles that had been identical by descent (IBD) for the first time (F_<sub>KAL_NEW</sub>) had a negative effect on both traits, while F_<sub>KAL</sub> has shown favorable results for alleles IBD in past generations. Some authors had proven this phenomenon in captive populations or experimental conditions; however, no evidence of inbreeding purge has ever been described in dog populations. Despite the various breeding practices, it seems that alleles of these polygenic disorders could be successfully purged out of the population with long-term selection.https://www.mdpi.com/2076-2615/10/10/1743border collieinbreedingpurginghip dysplasiaelbow dysplasia |
| spellingShingle | Virág Ács György Kövér János Farkas Árpád Bokor István Nagy Effects of Long-Term Selection in the Border Collie Dog Breed: Inbreeding Purge of Canine Hip and Elbow Dysplasia Animals border collie inbreeding purging hip dysplasia elbow dysplasia |
| title | Effects of Long-Term Selection in the Border Collie Dog Breed: Inbreeding Purge of Canine Hip and Elbow Dysplasia |
| title_full | Effects of Long-Term Selection in the Border Collie Dog Breed: Inbreeding Purge of Canine Hip and Elbow Dysplasia |
| title_fullStr | Effects of Long-Term Selection in the Border Collie Dog Breed: Inbreeding Purge of Canine Hip and Elbow Dysplasia |
| title_full_unstemmed | Effects of Long-Term Selection in the Border Collie Dog Breed: Inbreeding Purge of Canine Hip and Elbow Dysplasia |
| title_short | Effects of Long-Term Selection in the Border Collie Dog Breed: Inbreeding Purge of Canine Hip and Elbow Dysplasia |
| title_sort | effects of long term selection in the border collie dog breed inbreeding purge of canine hip and elbow dysplasia |
| topic | border collie inbreeding purging hip dysplasia elbow dysplasia |
| url | https://www.mdpi.com/2076-2615/10/10/1743 |
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