Assessment of atherosclerosis and endothelial dysfunction risk factors in patients with primary glomerulonephritis
Abstract Introduction: Glomerulonephritis are the third cause of chronic kidney disease (CKD) requiring dialysis in Brazil. Mineral and bone disorder (MBD) is one of the complications of CKD and is already present in the early stages. Assessment of carotid intima-media thickness (CIMT) and flow-med...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Nefrologia
2023-01-01
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| Series: | Brazilian Journal of Nephrology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002024000100029&lng=en&tlng=en |
| _version_ | 1797293973708996608 |
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| author | Rodrigo Hagemann Marcela Tatiana Watanabe João Carlos Hueb Luis Cuadrado Martín Vanessa dos Santos Silva Jacqueline do Socorro Costa Teixeira Caramori |
| author_facet | Rodrigo Hagemann Marcela Tatiana Watanabe João Carlos Hueb Luis Cuadrado Martín Vanessa dos Santos Silva Jacqueline do Socorro Costa Teixeira Caramori |
| author_sort | Rodrigo Hagemann |
| collection | DOAJ |
| description | Abstract Introduction: Glomerulonephritis are the third cause of chronic kidney disease (CKD) requiring dialysis in Brazil. Mineral and bone disorder (MBD) is one of the complications of CKD and is already present in the early stages. Assessment of carotid intima-media thickness (CIMT) and flow-mediated vasodilatation (FMV) are non-invasive ways of assessing cardiovascular risk. Hypothesis: Patients with primary glomerulonephritis (PG) have high prevalence of atherosclerosis and endothelial dysfunction, not fully explained by traditional risk factors, but probably influenced by the early onset of MBD. Objective: To evaluate the main markers of atherosclerosis in patients with PG. Method: Clinical, observational, cross-sectional and controlled study. Patients with PG were included and those under 18 years of age, pregnants, those with less than three months of follow-up and those with secondary glomerulonephritis were excluded. Those who, at the time of exams collection, had proteinuria higher than 6 grams/24 hours and using prednisone at doses higher than 0.2 mg/kg/day were also excluded. Results: 95 patients were included, 88 collected the exams, 1 was excluded and 23 did not undergo the ultrasound scan. Patients with PG had a higher mean CIMT compared to controls (0.66 versus 0.60), p = 0.003. After multivariate analysis, age and values for systolic blood pressure (SBP), FMV and GFR (p = 0.02); and FMV and serum uric acid (p = 0.048) remained statistically relevant. Discussion and conclusion: The higher cardiovascular risk in patients with PG was not explained by early MBD. Randomized and multicentric clinical studies are necessary to better assess this hypothesis. |
| first_indexed | 2024-03-07T21:23:28Z |
| format | Article |
| id | doaj.art-fb9516b472714500ba9f772377edf3ff |
| institution | Directory Open Access Journal |
| issn | 2175-8239 |
| language | English |
| last_indexed | 2024-03-07T21:23:28Z |
| publishDate | 2023-01-01 |
| publisher | Sociedade Brasileira de Nefrologia |
| record_format | Article |
| series | Brazilian Journal of Nephrology |
| spelling | doaj.art-fb9516b472714500ba9f772377edf3ff2024-02-27T07:42:58ZengSociedade Brasileira de NefrologiaBrazilian Journal of Nephrology2175-82392023-01-01461293810.1590/2175-8239-jbn-2022-0116enAssessment of atherosclerosis and endothelial dysfunction risk factors in patients with primary glomerulonephritisRodrigo Hagemannhttps://orcid.org/0000-0002-0870-7882Marcela Tatiana WatanabeJoão Carlos HuebLuis Cuadrado Martínhttps://orcid.org/0000-0003-1435-7994Vanessa dos Santos SilvaJacqueline do Socorro Costa Teixeira CaramoriAbstract Introduction: Glomerulonephritis are the third cause of chronic kidney disease (CKD) requiring dialysis in Brazil. Mineral and bone disorder (MBD) is one of the complications of CKD and is already present in the early stages. Assessment of carotid intima-media thickness (CIMT) and flow-mediated vasodilatation (FMV) are non-invasive ways of assessing cardiovascular risk. Hypothesis: Patients with primary glomerulonephritis (PG) have high prevalence of atherosclerosis and endothelial dysfunction, not fully explained by traditional risk factors, but probably influenced by the early onset of MBD. Objective: To evaluate the main markers of atherosclerosis in patients with PG. Method: Clinical, observational, cross-sectional and controlled study. Patients with PG were included and those under 18 years of age, pregnants, those with less than three months of follow-up and those with secondary glomerulonephritis were excluded. Those who, at the time of exams collection, had proteinuria higher than 6 grams/24 hours and using prednisone at doses higher than 0.2 mg/kg/day were also excluded. Results: 95 patients were included, 88 collected the exams, 1 was excluded and 23 did not undergo the ultrasound scan. Patients with PG had a higher mean CIMT compared to controls (0.66 versus 0.60), p = 0.003. After multivariate analysis, age and values for systolic blood pressure (SBP), FMV and GFR (p = 0.02); and FMV and serum uric acid (p = 0.048) remained statistically relevant. Discussion and conclusion: The higher cardiovascular risk in patients with PG was not explained by early MBD. Randomized and multicentric clinical studies are necessary to better assess this hypothesis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002024000100029&lng=en&tlng=enGlomerulonephritisRenal Insufficiency, ChronicChronic Kidney Disease-Mineral and Bone DisorderCardiovascular diseases |
| spellingShingle | Rodrigo Hagemann Marcela Tatiana Watanabe João Carlos Hueb Luis Cuadrado Martín Vanessa dos Santos Silva Jacqueline do Socorro Costa Teixeira Caramori Assessment of atherosclerosis and endothelial dysfunction risk factors in patients with primary glomerulonephritis Brazilian Journal of Nephrology Glomerulonephritis Renal Insufficiency, Chronic Chronic Kidney Disease-Mineral and Bone Disorder Cardiovascular diseases |
| title | Assessment of atherosclerosis and endothelial dysfunction risk factors in patients with primary glomerulonephritis |
| title_full | Assessment of atherosclerosis and endothelial dysfunction risk factors in patients with primary glomerulonephritis |
| title_fullStr | Assessment of atherosclerosis and endothelial dysfunction risk factors in patients with primary glomerulonephritis |
| title_full_unstemmed | Assessment of atherosclerosis and endothelial dysfunction risk factors in patients with primary glomerulonephritis |
| title_short | Assessment of atherosclerosis and endothelial dysfunction risk factors in patients with primary glomerulonephritis |
| title_sort | assessment of atherosclerosis and endothelial dysfunction risk factors in patients with primary glomerulonephritis |
| topic | Glomerulonephritis Renal Insufficiency, Chronic Chronic Kidney Disease-Mineral and Bone Disorder Cardiovascular diseases |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002024000100029&lng=en&tlng=en |
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