Indomethacin Electrospun Nanofibers for Colonic Drug Delivery: Preparation and Characterization
Purpose: The objective of this study was to prepare a suitable form of nanofiber for indomethacin using polymers Eudragit RS100 (ERS) and Eudragit S100 (ES) and to evaluate the effect of some variables on the characteristics of resulted electrospunnanofibers. Methods: Electrospinning process was use...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2013-02-01
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| Series: | Advanced Pharmaceutical Bulletin |
| Subjects: | |
| Online Access: | http://journals.tbzmed.ac.ir/PDF/APB/Manuscript/APB-3-85.pdf |
| _version_ | 1819036555356930048 |
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| author | Behzad Sharif Makhmalzadeh Zohreh Heshmati Abbas Akhgari |
| author_facet | Behzad Sharif Makhmalzadeh Zohreh Heshmati Abbas Akhgari |
| author_sort | Behzad Sharif Makhmalzadeh |
| collection | DOAJ |
| description | Purpose: The objective of this study was to prepare a suitable form of nanofiber for indomethacin using polymers Eudragit RS100 (ERS) and Eudragit S100 (ES) and to evaluate the effect of some variables on the characteristics of resulted electrospunnanofibers. Methods: Electrospinning process was used for preparation of nanofibers. Different solutions of combinations of ERS, ES and indomethacin in various solvents and different ratios were prepared. The spinning solutions were loaded in 10 mL syringes. The feeding rate was fixed by a syringe pump at 2.0 mL/h and a high voltage supply at range 10-18 kV was applied for electrospinning. Electrospunnanofibers were collected and evaluated by scanning electron microscopy, differential scanning calorimetry and FTIR for possible interaction between materials used in nanofibers. The effect of solvent and viscosity on the characteristics of nanofibers also was investigated. Results: Fiber formation was successful using a solvent ethanol and mixture of ERS and ES. Increase in viscosity of ethanolic solutions of ERS followed by addition of ES in the solution led to preparation of smooth fibers with larger diameters and less amounts of beads. DSC analysis of fibers certified that indomethacin is evenly distributed in the nanofibers in an amorphous state. FTIR analysis did not indicate significant interaction between drug and polymer. Conclusion: It was shown that drug-loaded ERS and ES nanofibers could be prepared by exact selection of range of variables such as type of solvent, drug: polymer ratio and solution viscosity and the optimized formulations could be useful for colonic drug delivery. |
| first_indexed | 2024-12-21T08:07:23Z |
| format | Article |
| id | doaj.art-fb9674652214409c839a3abe3846c3d0 |
| institution | Directory Open Access Journal |
| issn | 2228-5881 2251-7308 |
| language | English |
| last_indexed | 2024-12-21T08:07:23Z |
| publishDate | 2013-02-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj.art-fb9674652214409c839a3abe3846c3d02022-12-21T19:10:46ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082013-02-0131859010.5681/apb.2013.014Indomethacin Electrospun Nanofibers for Colonic Drug Delivery: Preparation and CharacterizationBehzad Sharif MakhmalzadehZohreh HeshmatiAbbas AkhgariPurpose: The objective of this study was to prepare a suitable form of nanofiber for indomethacin using polymers Eudragit RS100 (ERS) and Eudragit S100 (ES) and to evaluate the effect of some variables on the characteristics of resulted electrospunnanofibers. Methods: Electrospinning process was used for preparation of nanofibers. Different solutions of combinations of ERS, ES and indomethacin in various solvents and different ratios were prepared. The spinning solutions were loaded in 10 mL syringes. The feeding rate was fixed by a syringe pump at 2.0 mL/h and a high voltage supply at range 10-18 kV was applied for electrospinning. Electrospunnanofibers were collected and evaluated by scanning electron microscopy, differential scanning calorimetry and FTIR for possible interaction between materials used in nanofibers. The effect of solvent and viscosity on the characteristics of nanofibers also was investigated. Results: Fiber formation was successful using a solvent ethanol and mixture of ERS and ES. Increase in viscosity of ethanolic solutions of ERS followed by addition of ES in the solution led to preparation of smooth fibers with larger diameters and less amounts of beads. DSC analysis of fibers certified that indomethacin is evenly distributed in the nanofibers in an amorphous state. FTIR analysis did not indicate significant interaction between drug and polymer. Conclusion: It was shown that drug-loaded ERS and ES nanofibers could be prepared by exact selection of range of variables such as type of solvent, drug: polymer ratio and solution viscosity and the optimized formulations could be useful for colonic drug delivery.http://journals.tbzmed.ac.ir/PDF/APB/Manuscript/APB-3-85.pdfElectrospunNanofiberIndomethacinEudragit |
| spellingShingle | Behzad Sharif Makhmalzadeh Zohreh Heshmati Abbas Akhgari Indomethacin Electrospun Nanofibers for Colonic Drug Delivery: Preparation and Characterization Advanced Pharmaceutical Bulletin Electrospun Nanofiber Indomethacin Eudragit |
| title | Indomethacin Electrospun Nanofibers for Colonic Drug Delivery: Preparation and Characterization |
| title_full | Indomethacin Electrospun Nanofibers for Colonic Drug Delivery: Preparation and Characterization |
| title_fullStr | Indomethacin Electrospun Nanofibers for Colonic Drug Delivery: Preparation and Characterization |
| title_full_unstemmed | Indomethacin Electrospun Nanofibers for Colonic Drug Delivery: Preparation and Characterization |
| title_short | Indomethacin Electrospun Nanofibers for Colonic Drug Delivery: Preparation and Characterization |
| title_sort | indomethacin electrospun nanofibers for colonic drug delivery preparation and characterization |
| topic | Electrospun Nanofiber Indomethacin Eudragit |
| url | http://journals.tbzmed.ac.ir/PDF/APB/Manuscript/APB-3-85.pdf |
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