The Role of Cholesterol on Triterpenoid Saponin-Induced Endolysosomal Escape of a Saporin-Based Immunotoxin

The Role of Cholesterol on Triterpenoid Saponin-Induced Endolysosomal Escape of a Saporin-Based Immunotoxin

Cholesterol seems to play a central role in the augmentation of saporin-based immunotoxin (IT) cytotoxicity by triterpenoid saponins. Endolysosomal escape has been proposed as one mechanism for the saponin-mediated enhancement of targeted toxins. We investigated the effects of lipid depletion follow...

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Bibliographic Details
Main Authors: Wendy S. Smith, David A. Johnston, Harrison J. Wensley, Suzanne E. Holmes, Sopsamorn U. Flavell, David J. Flavell
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
saponin
endosomal escape
cholesterol
immunotoxin
augmentation
saporin
Online Access:https://www.mdpi.com/1422-0067/21/22/8734

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