Genetic predisposition in nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease whose prevalence has reached global epidemic proportions. Although the disease is relatively benign in the early stages, when severe clinical forms, including nonalcoholic steatohepatitis (NASH), cirrhosis and even hep...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Association for the Study of the Liver
2017-03-01
|
| Series: | Clinical and Molecular Hepatology |
| Subjects: | |
| Online Access: | http://e-cmh.org/upload/pdf/cmh-2016-0109.pdf |
| _version_ | 1828739099707572224 |
|---|---|
| author | Silvia Sookoian Carlos J. Pirola |
| author_facet | Silvia Sookoian Carlos J. Pirola |
| author_sort | Silvia Sookoian |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease whose prevalence has reached global epidemic proportions. Although the disease is relatively benign in the early stages, when severe clinical forms, including nonalcoholic steatohepatitis (NASH), cirrhosis and even hepatocellular carcinoma, occur, they result in worsening the long-term prognosis. A growing body of evidence indicates that NAFLD develops from a complex process in which many factors, including genetic susceptibility and environmental insults, are involved. In this review, we focused on the genetic component of NAFLD, with special emphasis on the role of genetics in the disease pathogenesis and natural history. Insights into the topic of the genetic susceptibility in lean individuals with NAFLD and the potential use of genetic tests in identifying individuals at risk are also discussed. |
| first_indexed | 2024-04-13T00:16:22Z |
| format | Article |
| id | doaj.art-fb981d42021149e682a52e5ecfc8263c |
| institution | Directory Open Access Journal |
| issn | 2287-2728 2287-285X |
| language | English |
| last_indexed | 2024-04-13T00:16:22Z |
| publishDate | 2017-03-01 |
| publisher | Korean Association for the Study of the Liver |
| record_format | Article |
| series | Clinical and Molecular Hepatology |
| spelling | doaj.art-fb981d42021149e682a52e5ecfc8263c2022-12-22T03:10:56ZengKorean Association for the Study of the LiverClinical and Molecular Hepatology2287-27282287-285X2017-03-0123111210.3350/cmh.2016.01091338Genetic predisposition in nonalcoholic fatty liver diseaseSilvia Sookoian0Carlos J. Pirola1 Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires – National Scientific and Technical Research Council (CONICET), Ciudad Autónoma de Buenos Aires,Argentina Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires – National Scientific and Technical Research Council (CONICET), Ciudad Autónoma de Buenos Aires,ArgentinaNonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease whose prevalence has reached global epidemic proportions. Although the disease is relatively benign in the early stages, when severe clinical forms, including nonalcoholic steatohepatitis (NASH), cirrhosis and even hepatocellular carcinoma, occur, they result in worsening the long-term prognosis. A growing body of evidence indicates that NAFLD develops from a complex process in which many factors, including genetic susceptibility and environmental insults, are involved. In this review, we focused on the genetic component of NAFLD, with special emphasis on the role of genetics in the disease pathogenesis and natural history. Insights into the topic of the genetic susceptibility in lean individuals with NAFLD and the potential use of genetic tests in identifying individuals at risk are also discussed.http://e-cmh.org/upload/pdf/cmh-2016-0109.pdfNASHalcoholic liver diseasegene variants |
| spellingShingle | Silvia Sookoian Carlos J. Pirola Genetic predisposition in nonalcoholic fatty liver disease Clinical and Molecular Hepatology NASH alcoholic liver disease gene variants |
| title | Genetic predisposition in nonalcoholic fatty liver disease |
| title_full | Genetic predisposition in nonalcoholic fatty liver disease |
| title_fullStr | Genetic predisposition in nonalcoholic fatty liver disease |
| title_full_unstemmed | Genetic predisposition in nonalcoholic fatty liver disease |
| title_short | Genetic predisposition in nonalcoholic fatty liver disease |
| title_sort | genetic predisposition in nonalcoholic fatty liver disease |
| topic | NASH alcoholic liver disease gene variants |
| url | http://e-cmh.org/upload/pdf/cmh-2016-0109.pdf |
| work_keys_str_mv | AT silviasookoian geneticpredispositioninnonalcoholicfattyliverdisease AT carlosjpirola geneticpredispositioninnonalcoholicfattyliverdisease |