Lung adenocarcinoma without stromal invasion accompanied by spread through alveolar spaces: A case report
Introduction: Lung cancer presenting as ground-glass nodules (GGNs) with little consolidation is often diagnosed as noninvasive carcinoma. Increasing evidence suggests that sublobar lung resection, such as wedge resection, provides satisfactory long-term outcomes equivalent to those of lobectomy. Sp...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Current Problems in Cancer: Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666621922000680 |
| _version_ | 1811201637240274944 |
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| author | Kimihiko Kobayashi Masaaki Sato Shun Kawashima Masahiro Yanagiya Masaaki Nagano Chihiro Konoeda Kentaro Kitano Munetoshi Hinata Masako Ikemura Aya Shinozaki-Ushiku Jun Nakajima |
| author_facet | Kimihiko Kobayashi Masaaki Sato Shun Kawashima Masahiro Yanagiya Masaaki Nagano Chihiro Konoeda Kentaro Kitano Munetoshi Hinata Masako Ikemura Aya Shinozaki-Ushiku Jun Nakajima |
| author_sort | Kimihiko Kobayashi |
| collection | DOAJ |
| description | Introduction: Lung cancer presenting as ground-glass nodules (GGNs) with little consolidation is often diagnosed as noninvasive carcinoma. Increasing evidence suggests that sublobar lung resection, such as wedge resection, provides satisfactory long-term outcomes equivalent to those of lobectomy. Spread through alveolar spaces (STAS) is a reported risk factor for recurrence, especially when sublobar lung resection is applied. We herein report a rare case of a pure GGN that was histologically confirmed to be adenocarcinoma in situ (AIS) and associated STAS after limited resection. Case presentation: A 67-year-old woman presented with an 8-mm pure GGN in S2 of the right upper lobe and a part-solid GGN in S8 of the right lower lobe. The clinical stages of these GGNs were TisN0M0 stage 0 and T1aN0M0 stage IA1, respectively. The patient underwent video-assisted thoracoscopic segmentectomies of S2 and S8. Histopathological examination of the resected specimens revealed minimally invasive adenocarcinoma in S8 and AIS in S2. Stromal invasion was not observed in the tumor located in S2, but a tumor cell cluster was found in the air space located away from the AIS lesion. Thus, the lesion was positive for STAS. Conclusion: We have reported a rare case of a pure GGN that was histologically STAS-positive, otherwise diagnosed as AIS after limited resection. |
| first_indexed | 2024-04-12T02:25:05Z |
| format | Article |
| id | doaj.art-fb998911428a4ad0ad7a5c02ce4ffaf7 |
| institution | Directory Open Access Journal |
| issn | 2666-6219 |
| language | English |
| last_indexed | 2024-04-12T02:25:05Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Problems in Cancer: Case Reports |
| spelling | doaj.art-fb998911428a4ad0ad7a5c02ce4ffaf72022-12-22T03:52:02ZengElsevierCurrent Problems in Cancer: Case Reports2666-62192022-12-018100204Lung adenocarcinoma without stromal invasion accompanied by spread through alveolar spaces: A case reportKimihiko Kobayashi0Masaaki Sato1Shun Kawashima2Masahiro Yanagiya3Masaaki Nagano4Chihiro Konoeda5Kentaro Kitano6Munetoshi Hinata7Masako Ikemura8Aya Shinozaki-Ushiku9Jun Nakajima10Department of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, JapanDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan; Corresponding author.Department of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, JapanDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, JapanDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, JapanDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, JapanDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, JapanDepartment of Pathology, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, JapanDepartment of Pathology, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, JapanDepartment of Pathology, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, JapanDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, JapanIntroduction: Lung cancer presenting as ground-glass nodules (GGNs) with little consolidation is often diagnosed as noninvasive carcinoma. Increasing evidence suggests that sublobar lung resection, such as wedge resection, provides satisfactory long-term outcomes equivalent to those of lobectomy. Spread through alveolar spaces (STAS) is a reported risk factor for recurrence, especially when sublobar lung resection is applied. We herein report a rare case of a pure GGN that was histologically confirmed to be adenocarcinoma in situ (AIS) and associated STAS after limited resection. Case presentation: A 67-year-old woman presented with an 8-mm pure GGN in S2 of the right upper lobe and a part-solid GGN in S8 of the right lower lobe. The clinical stages of these GGNs were TisN0M0 stage 0 and T1aN0M0 stage IA1, respectively. The patient underwent video-assisted thoracoscopic segmentectomies of S2 and S8. Histopathological examination of the resected specimens revealed minimally invasive adenocarcinoma in S8 and AIS in S2. Stromal invasion was not observed in the tumor located in S2, but a tumor cell cluster was found in the air space located away from the AIS lesion. Thus, the lesion was positive for STAS. Conclusion: We have reported a rare case of a pure GGN that was histologically STAS-positive, otherwise diagnosed as AIS after limited resection.http://www.sciencedirect.com/science/article/pii/S2666621922000680Lung cancerGround-glass noduleSpread through alveolar spacesLimited resection |
| spellingShingle | Kimihiko Kobayashi Masaaki Sato Shun Kawashima Masahiro Yanagiya Masaaki Nagano Chihiro Konoeda Kentaro Kitano Munetoshi Hinata Masako Ikemura Aya Shinozaki-Ushiku Jun Nakajima Lung adenocarcinoma without stromal invasion accompanied by spread through alveolar spaces: A case report Current Problems in Cancer: Case Reports Lung cancer Ground-glass nodule Spread through alveolar spaces Limited resection |
| title | Lung adenocarcinoma without stromal invasion accompanied by spread through alveolar spaces: A case report |
| title_full | Lung adenocarcinoma without stromal invasion accompanied by spread through alveolar spaces: A case report |
| title_fullStr | Lung adenocarcinoma without stromal invasion accompanied by spread through alveolar spaces: A case report |
| title_full_unstemmed | Lung adenocarcinoma without stromal invasion accompanied by spread through alveolar spaces: A case report |
| title_short | Lung adenocarcinoma without stromal invasion accompanied by spread through alveolar spaces: A case report |
| title_sort | lung adenocarcinoma without stromal invasion accompanied by spread through alveolar spaces a case report |
| topic | Lung cancer Ground-glass nodule Spread through alveolar spaces Limited resection |
| url | http://www.sciencedirect.com/science/article/pii/S2666621922000680 |
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