Cardiovascular and metabolic health is associated with functional brain connectivity in middle-aged and older adults: Results from the Human Connectome Project-Aging study
Several cardiovascular and metabolic indicators, such as cholesterol and blood pressure have been associated with altered neural and cognitive health as well as increased risk of dementia and Alzheimer's disease in later life. In this cross-sectional study, we examined how an aggregate index of...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811923003439 |
| _version_ | 1797799117218381824 |
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| author | Barnaly Rashid Matthew F. Glasser Thomas Nichols David Van Essen Meher R. Juttukonda Nadine A. Schwab Douglas N Greve Essa Yacoub Allison Lovely Melissa Terpstra Michael P. Harms Susan Y. Bookheimer Beau M. Ances David H. Salat Steven E. Arnold |
| author_facet | Barnaly Rashid Matthew F. Glasser Thomas Nichols David Van Essen Meher R. Juttukonda Nadine A. Schwab Douglas N Greve Essa Yacoub Allison Lovely Melissa Terpstra Michael P. Harms Susan Y. Bookheimer Beau M. Ances David H. Salat Steven E. Arnold |
| author_sort | Barnaly Rashid |
| collection | DOAJ |
| description | Several cardiovascular and metabolic indicators, such as cholesterol and blood pressure have been associated with altered neural and cognitive health as well as increased risk of dementia and Alzheimer's disease in later life. In this cross-sectional study, we examined how an aggregate index of cardiovascular and metabolic risk factor measures was associated with correlation-based estimates of resting-state functional connectivity (FC) across a broad adult age-span (36–90+ years) from 930 volunteers in the Human Connectome Project Aging (HCP-A). Increased (i.e., worse) aggregate cardiometabolic scores were associated with reduced FC globally, with especially strong effects in insular, medial frontal, medial parietal, and superior temporal regions. Additionally, at the network-level, FC between core brain networks, such as default-mode and cingulo-opercular, as well as dorsal attention networks, showed strong effects of cardiometabolic risk. These findings highlight the lifespan impact of cardiovascular and metabolic health on whole-brain functional integrity and how these conditions may disrupt higher-order network integrity. |
| first_indexed | 2024-03-13T04:15:11Z |
| format | Article |
| id | doaj.art-fb9aaac7b02641d0b4aee85c24b52e5f |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-03-13T04:15:11Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-fb9aaac7b02641d0b4aee85c24b52e5f2023-06-21T06:51:09ZengElsevierNeuroImage1095-95722023-08-01276120192Cardiovascular and metabolic health is associated with functional brain connectivity in middle-aged and older adults: Results from the Human Connectome Project-Aging studyBarnaly Rashid0Matthew F. Glasser1Thomas Nichols2David Van Essen3Meher R. Juttukonda4Nadine A. Schwab5Douglas N Greve6Essa Yacoub7Allison Lovely8Melissa Terpstra9Michael P. Harms10Susan Y. Bookheimer11Beau M. Ances12David H. Salat13Steven E. Arnold14Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St., Charlestown, MA 02129, United States; Harvard Medical School, Boston, MA, United States; Corresponding authors.Washington University School of Medicine, St. Louis, MO, United StatesUniversity of Oxford, Oxford, United KingdomWashington University School of Medicine, St. Louis, MO, United StatesAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St., Charlestown, MA 02129, United States; Harvard Medical School, Boston, MA, United StatesAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St., Charlestown, MA 02129, United States; Harvard Medical School, Boston, MA, United StatesAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St., Charlestown, MA 02129, United States; Harvard Medical School, Boston, MA, United StatesCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United StatesAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St., Charlestown, MA 02129, United States; Harvard Medical School, Boston, MA, United StatesUniversity of Minnesota, Minneapolis, MN, United StatesWashington University in St. Louis, St. Louis, MO, United StatesUniversity of California, Los Angeles, Los Angeles, CA, United StatesWashington University School of Medicine, St. Louis, MO, United States; Washington University in St. Louis, St. Louis, MO, United StatesAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St., Charlestown, MA 02129, United States; Harvard Medical School, Boston, MA, United States; Corresponding authors.Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St., Charlestown, MA 02129, United States; Harvard Medical School, Boston, MA, United States; Corresponding authors.Several cardiovascular and metabolic indicators, such as cholesterol and blood pressure have been associated with altered neural and cognitive health as well as increased risk of dementia and Alzheimer's disease in later life. In this cross-sectional study, we examined how an aggregate index of cardiovascular and metabolic risk factor measures was associated with correlation-based estimates of resting-state functional connectivity (FC) across a broad adult age-span (36–90+ years) from 930 volunteers in the Human Connectome Project Aging (HCP-A). Increased (i.e., worse) aggregate cardiometabolic scores were associated with reduced FC globally, with especially strong effects in insular, medial frontal, medial parietal, and superior temporal regions. Additionally, at the network-level, FC between core brain networks, such as default-mode and cingulo-opercular, as well as dorsal attention networks, showed strong effects of cardiometabolic risk. These findings highlight the lifespan impact of cardiovascular and metabolic health on whole-brain functional integrity and how these conditions may disrupt higher-order network integrity.http://www.sciencedirect.com/science/article/pii/S1053811923003439Resting-state fMRICardiovascular riskFunctional connectivityAgingAlzheimer's disease |
| spellingShingle | Barnaly Rashid Matthew F. Glasser Thomas Nichols David Van Essen Meher R. Juttukonda Nadine A. Schwab Douglas N Greve Essa Yacoub Allison Lovely Melissa Terpstra Michael P. Harms Susan Y. Bookheimer Beau M. Ances David H. Salat Steven E. Arnold Cardiovascular and metabolic health is associated with functional brain connectivity in middle-aged and older adults: Results from the Human Connectome Project-Aging study NeuroImage Resting-state fMRI Cardiovascular risk Functional connectivity Aging Alzheimer's disease |
| title | Cardiovascular and metabolic health is associated with functional brain connectivity in middle-aged and older adults: Results from the Human Connectome Project-Aging study |
| title_full | Cardiovascular and metabolic health is associated with functional brain connectivity in middle-aged and older adults: Results from the Human Connectome Project-Aging study |
| title_fullStr | Cardiovascular and metabolic health is associated with functional brain connectivity in middle-aged and older adults: Results from the Human Connectome Project-Aging study |
| title_full_unstemmed | Cardiovascular and metabolic health is associated with functional brain connectivity in middle-aged and older adults: Results from the Human Connectome Project-Aging study |
| title_short | Cardiovascular and metabolic health is associated with functional brain connectivity in middle-aged and older adults: Results from the Human Connectome Project-Aging study |
| title_sort | cardiovascular and metabolic health is associated with functional brain connectivity in middle aged and older adults results from the human connectome project aging study |
| topic | Resting-state fMRI Cardiovascular risk Functional connectivity Aging Alzheimer's disease |
| url | http://www.sciencedirect.com/science/article/pii/S1053811923003439 |
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