A multi-network comparative analysis of whole-transcriptome and translatome reveals the effect of high-fat diet on APP/PS1 mice and the intervention with Chinese medicine

A multi-network comparative analysis of whole-transcriptome and translatome reveals the effect of high-fat diet on APP/PS1 mice and the intervention with Chinese medicine

Different studies on the effects of high-fat diet (HFD) on Alzheimer’s disease (AD) pathology have reported conflicting findings. Our previous studies showed HFD could moderate neuroinflammation and had no significant effect on amyloid-β levels or contextual memory on AD mice. To gain more insights...

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Bibliographic Details
Main Authors: Wenya Gao, Junyi Zhou, Xinru Gu, Yanyan Zhou, Linna Wang, Nan Si, Xiaorui Fan, Baolin Bian, Hongjie Wang, Haiyu Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Nutrition
Subjects:
Alzheimer’s disease
high-fat diet (HFD)
Ribo-seq
RNA-seq
Huanglian Jiedu Decoction
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2022.974333/full

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