Amyloid-β peptide triggers Fas-independent apoptosis and differentiation of neural progenitor cells

Amyloid-β peptide triggers Fas-independent apoptosis and differentiation of neural progenitor cells

Amyloid-β peptide (Aβ), derived from the amyloid-β precursor protein (APP), plays a central role in the pathogenesis of Alzheimer's disease and induces neuronal apoptosis. Neural progenitor cells persist in the adult mammalian brain and continue to produce new neurons throughout the life. The a...

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Bibliographic Details
Main Authors: Pascal Millet, Céline Silva Lages, Stéphane Haïk, Ewa Nowak, Isabelle Allemand, Christine Granotier, François D. Boussin
Format: Article
Language:English
Published: Elsevier 2005-06-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Neural progenitor cells
Amyloid peptide Aβ
Fas/CD95/Apo1
Neurogenesis
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104002785

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