Dynamics within the CD95 death‐inducing signaling complex decide life and death of cells

Dynamics within the CD95 death‐inducing signaling complex decide life and death of cells

Abstract This study explores the dilemma in cellular signaling that triggering of CD95 (Fas/APO‐1) in some situations results in cell death and in others leads to the activation of NF‐κB. We established an integrated kinetic mathematical model for CD95‐mediated apoptotic and NF‐κB signaling. Systema...

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Bibliographic Details
Main Authors: Leo Neumann, Carina Pforr, Joel Beaudouin, Alexander Pappa, Nicolai Fricker, Peter H Krammer, Inna N Lavrik, Roland Eils
Format: Article
Language:English
Published: Springer Nature 2010-03-01
Series:Molecular Systems Biology
Subjects:
apoptosis
CD95 signaling
DISC
model reduction
NF‐κB
Online Access:https://doi.org/10.1038/msb.2010.6

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