Survival-Associated Metabolic Genes in Human Papillomavirus-Positive Head and Neck Cancers
Human papillomavirus (HPV) causes an increasing number of head and neck squamous cell carcinomas (HNSCCs). Altered metabolism contributes to patient prognosis, but the impact of HPV status on HNSCC metabolism remains relatively uncharacterized. We hypothesize that metabolism-related gene expression...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/1/253 |
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| author | Martin A. Prusinkiewicz Steven F. Gameiro Farhad Ghasemi Mackenzie J. Dodge Peter Y. F. Zeng Hanna Maekebay John W. Barrett Anthony C. Nichols Joe S. Mymryk |
| author_facet | Martin A. Prusinkiewicz Steven F. Gameiro Farhad Ghasemi Mackenzie J. Dodge Peter Y. F. Zeng Hanna Maekebay John W. Barrett Anthony C. Nichols Joe S. Mymryk |
| author_sort | Martin A. Prusinkiewicz |
| collection | DOAJ |
| description | Human papillomavirus (HPV) causes an increasing number of head and neck squamous cell carcinomas (HNSCCs). Altered metabolism contributes to patient prognosis, but the impact of HPV status on HNSCC metabolism remains relatively uncharacterized. We hypothesize that metabolism-related gene expression differences unique to HPV-positive HNSCC influences patient survival. The Cancer Genome Atlas RNA-seq data from primary HNSCC patient samples were categorized as 73 HPV-positive, 442 HPV-negative, and 43 normal-adjacent control tissues. We analyzed 229 metabolic genes and identified numerous differentially expressed genes between HPV-positive and negative HNSCC patients. HPV-positive carcinomas exhibited lower expression levels of genes involved in glycolysis and higher levels of genes involved in the tricarboxylic acid cycle, oxidative phosphorylation, and β-oxidation than the HPV-negative carcinomas. Importantly, reduced expression of the metabolism-related genes <i>SDHC</i>, <i>COX7A1</i>, <i>COX16</i>, <i>COX17</i>, <i>ELOVL6</i>, <i>GOT2</i>, and <i>SLC16A2</i> were correlated with improved patient survival only in the HPV-positive group. This work suggests that specific transcriptional alterations in metabolic genes may serve as predictive biomarkers of patient outcome and identifies potential targets for novel therapeutic intervention in HPV-positive head and neck cancers. |
| first_indexed | 2024-03-12T06:30:37Z |
| format | Article |
| id | doaj.art-fb9c7cd0b4c849a89c1a335fe65a4839 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T06:30:37Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-fb9c7cd0b4c849a89c1a335fe65a48392023-09-03T01:39:31ZengMDPI AGCancers2072-66942020-01-0112125310.3390/cancers12010253cancers12010253Survival-Associated Metabolic Genes in Human Papillomavirus-Positive Head and Neck CancersMartin A. Prusinkiewicz0Steven F. Gameiro1Farhad Ghasemi2Mackenzie J. Dodge3Peter Y. F. Zeng4Hanna Maekebay5John W. Barrett6Anthony C. Nichols7Joe S. Mymryk8Department of Microbiology and Immunology, The University of Western Ontario, London, ON N6A 3K7, CanadaDepartment of Microbiology and Immunology, The University of Western Ontario, London, ON N6A 3K7, CanadaDepartment of Surgery, The University of Western Ontario, London, ON N6A 3K7, CanadaDepartment of Microbiology and Immunology, The University of Western Ontario, London, ON N6A 3K7, CanadaDepartment of Otolaryngology, Head & Neck Surgery, The University of Western Ontario, London, ON N6A 3K7, CanadaDepartment of Microbiology and Immunology, The University of Western Ontario, London, ON N6A 3K7, CanadaDepartment of Otolaryngology, Head & Neck Surgery, The University of Western Ontario, London, ON N6A 3K7, CanadaDepartment of Otolaryngology, Head & Neck Surgery, The University of Western Ontario, London, ON N6A 3K7, CanadaDepartment of Microbiology and Immunology, The University of Western Ontario, London, ON N6A 3K7, CanadaHuman papillomavirus (HPV) causes an increasing number of head and neck squamous cell carcinomas (HNSCCs). Altered metabolism contributes to patient prognosis, but the impact of HPV status on HNSCC metabolism remains relatively uncharacterized. We hypothesize that metabolism-related gene expression differences unique to HPV-positive HNSCC influences patient survival. The Cancer Genome Atlas RNA-seq data from primary HNSCC patient samples were categorized as 73 HPV-positive, 442 HPV-negative, and 43 normal-adjacent control tissues. We analyzed 229 metabolic genes and identified numerous differentially expressed genes between HPV-positive and negative HNSCC patients. HPV-positive carcinomas exhibited lower expression levels of genes involved in glycolysis and higher levels of genes involved in the tricarboxylic acid cycle, oxidative phosphorylation, and β-oxidation than the HPV-negative carcinomas. Importantly, reduced expression of the metabolism-related genes <i>SDHC</i>, <i>COX7A1</i>, <i>COX16</i>, <i>COX17</i>, <i>ELOVL6</i>, <i>GOT2</i>, and <i>SLC16A2</i> were correlated with improved patient survival only in the HPV-positive group. This work suggests that specific transcriptional alterations in metabolic genes may serve as predictive biomarkers of patient outcome and identifies potential targets for novel therapeutic intervention in HPV-positive head and neck cancers.https://www.mdpi.com/2072-6694/12/1/253human papillomavirushead and neck cancercancer metabolismglycolysiscellular respirationtcga |
| spellingShingle | Martin A. Prusinkiewicz Steven F. Gameiro Farhad Ghasemi Mackenzie J. Dodge Peter Y. F. Zeng Hanna Maekebay John W. Barrett Anthony C. Nichols Joe S. Mymryk Survival-Associated Metabolic Genes in Human Papillomavirus-Positive Head and Neck Cancers Cancers human papillomavirus head and neck cancer cancer metabolism glycolysis cellular respiration tcga |
| title | Survival-Associated Metabolic Genes in Human Papillomavirus-Positive Head and Neck Cancers |
| title_full | Survival-Associated Metabolic Genes in Human Papillomavirus-Positive Head and Neck Cancers |
| title_fullStr | Survival-Associated Metabolic Genes in Human Papillomavirus-Positive Head and Neck Cancers |
| title_full_unstemmed | Survival-Associated Metabolic Genes in Human Papillomavirus-Positive Head and Neck Cancers |
| title_short | Survival-Associated Metabolic Genes in Human Papillomavirus-Positive Head and Neck Cancers |
| title_sort | survival associated metabolic genes in human papillomavirus positive head and neck cancers |
| topic | human papillomavirus head and neck cancer cancer metabolism glycolysis cellular respiration tcga |
| url | https://www.mdpi.com/2072-6694/12/1/253 |
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