Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytes
The molecular mechanisms explaining racial disparity in breast cancer mortality are not completely elucidated. Here, the authors show that an African-associated SNP in American breast cancer patients, leads to higher levels of microRNA miR-1304-3p which promotes cancer by increasing lipids availabil...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35305-2 |
| _version_ | 1811291789866303488 |
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| author | Dan Zhao Kerui Wu Sambad Sharma Fei Xing Shih-Ying Wu Abhishek Tyagi Ravindra Deshpande Ravi Singh Martin Wabitsch Yin-Yuan Mo Kounosuke Watabe |
| author_facet | Dan Zhao Kerui Wu Sambad Sharma Fei Xing Shih-Ying Wu Abhishek Tyagi Ravindra Deshpande Ravi Singh Martin Wabitsch Yin-Yuan Mo Kounosuke Watabe |
| author_sort | Dan Zhao |
| collection | DOAJ |
| description | The molecular mechanisms explaining racial disparity in breast cancer mortality are not completely elucidated. Here, the authors show that an African-associated SNP in American breast cancer patients, leads to higher levels of microRNA miR-1304-3p which promotes cancer by increasing lipids availability. |
| first_indexed | 2024-04-13T04:34:41Z |
| format | Article |
| id | doaj.art-fb9fe37c5fe14e659b074007429628f1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T04:34:41Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-fb9fe37c5fe14e659b074007429628f12022-12-22T03:02:13ZengNature PortfolioNature Communications2041-17232022-12-0113111510.1038/s41467-022-35305-2Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytesDan Zhao0Kerui Wu1Sambad Sharma2Fei Xing3Shih-Ying Wu4Abhishek Tyagi5Ravindra Deshpande6Ravi Singh7Martin Wabitsch8Yin-Yuan Mo9Kounosuke Watabe10Department of Cancer Biology, Wake Forest University School of MedicineDepartment of Cancer Biology, Wake Forest University School of MedicineDepartment of Cancer Biology, Wake Forest University School of MedicineDepartment of Cancer Biology, Wake Forest University School of MedicineDepartment of Cancer Biology, Wake Forest University School of MedicineDepartment of Cancer Biology, Wake Forest University School of MedicineDepartment of Cancer Biology, Wake Forest University School of MedicineDepartment of Cancer Biology, Wake Forest University School of MedicineDivision of Pediatric Endocrinology and Diabetes, Department of Pediatric and Adolescent Medicine, Ulm University Medical CenterCancer Institute, University of Mississippi Medical CenterDepartment of Cancer Biology, Wake Forest University School of MedicineThe molecular mechanisms explaining racial disparity in breast cancer mortality are not completely elucidated. Here, the authors show that an African-associated SNP in American breast cancer patients, leads to higher levels of microRNA miR-1304-3p which promotes cancer by increasing lipids availability.https://doi.org/10.1038/s41467-022-35305-2 |
| spellingShingle | Dan Zhao Kerui Wu Sambad Sharma Fei Xing Shih-Ying Wu Abhishek Tyagi Ravindra Deshpande Ravi Singh Martin Wabitsch Yin-Yuan Mo Kounosuke Watabe Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytes Nature Communications |
| title | Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytes |
| title_full | Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytes |
| title_fullStr | Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytes |
| title_full_unstemmed | Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytes |
| title_short | Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytes |
| title_sort | exosomal mir 1304 3p promotes breast cancer progression in african americans by activating cancer associated adipocytes |
| url | https://doi.org/10.1038/s41467-022-35305-2 |
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