The Role of the Microbiome in Oral Squamous Cell Carcinoma with Insight into the Microbiome–Treatment Axis
Oral squamous cell carcinoma (OSCC) is one of the leading presentations of head and neck cancer (HNC). The first part of this review will describe the highlights of the oral microbiome in health and normal development while demonstrating how both the oral and gut microbiome can map OSCC development,...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/21/8061 |
| _version_ | 1797549489552097280 |
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| author | Amel Sami Imad Elimairi Catherine Stanton R. Paul Ross C. Anthony Ryan |
| author_facet | Amel Sami Imad Elimairi Catherine Stanton R. Paul Ross C. Anthony Ryan |
| author_sort | Amel Sami |
| collection | DOAJ |
| description | Oral squamous cell carcinoma (OSCC) is one of the leading presentations of head and neck cancer (HNC). The first part of this review will describe the highlights of the oral microbiome in health and normal development while demonstrating how both the oral and gut microbiome can map OSCC development, progression, treatment and the potential side effects associated with its management. We then scope the dynamics of the various microorganisms of the oral cavity, including bacteria, mycoplasma, fungi, archaea and viruses, and describe the characteristic roles they may play in OSCC development. We also highlight how the human immunodeficiency viruses (HIV) may impinge on the host microbiome and increase the burden of oral premalignant lesions and OSCC in patients with HIV. Finally, we summarise current insights into the microbiome–treatment axis pertaining to OSCC, and show how the microbiome is affected by radiotherapy, chemotherapy, immunotherapy and also how these therapies are affected by the state of the microbiome, potentially determining the success or failure of some of these treatments. |
| first_indexed | 2024-03-10T15:16:24Z |
| format | Article |
| id | doaj.art-fba0e4da6414411aa5228706eee90611 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:16:24Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-fba0e4da6414411aa5228706eee906112023-11-20T18:58:21ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-10-012121806110.3390/ijms21218061The Role of the Microbiome in Oral Squamous Cell Carcinoma with Insight into the Microbiome–Treatment AxisAmel Sami0Imad Elimairi1Catherine Stanton2R. Paul Ross3C. Anthony Ryan4APC Microbiome Ireland, School of Microbiology, University College Cork, Cork T12 YN60, IrelandDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, National Ribat University, Nile Street, Khartoum 1111, SudanAPC Microbiome Ireland, School of Microbiology, University College Cork, Cork T12 YN60, IrelandAPC Microbiome Ireland, School of Microbiology, University College Cork, Cork T12 YN60, IrelandDepartment of Paediatrics and Child Health, University College Cork, Cork T12 DFK4, IrelandOral squamous cell carcinoma (OSCC) is one of the leading presentations of head and neck cancer (HNC). The first part of this review will describe the highlights of the oral microbiome in health and normal development while demonstrating how both the oral and gut microbiome can map OSCC development, progression, treatment and the potential side effects associated with its management. We then scope the dynamics of the various microorganisms of the oral cavity, including bacteria, mycoplasma, fungi, archaea and viruses, and describe the characteristic roles they may play in OSCC development. We also highlight how the human immunodeficiency viruses (HIV) may impinge on the host microbiome and increase the burden of oral premalignant lesions and OSCC in patients with HIV. Finally, we summarise current insights into the microbiome–treatment axis pertaining to OSCC, and show how the microbiome is affected by radiotherapy, chemotherapy, immunotherapy and also how these therapies are affected by the state of the microbiome, potentially determining the success or failure of some of these treatments.https://www.mdpi.com/1422-0067/21/21/8061oral microbiomegut microbiomeoral squamous cell carcinomahead and neck cancermicrobial |
| spellingShingle | Amel Sami Imad Elimairi Catherine Stanton R. Paul Ross C. Anthony Ryan The Role of the Microbiome in Oral Squamous Cell Carcinoma with Insight into the Microbiome–Treatment Axis International Journal of Molecular Sciences oral microbiome gut microbiome oral squamous cell carcinoma head and neck cancer microbial |
| title | The Role of the Microbiome in Oral Squamous Cell Carcinoma with Insight into the Microbiome–Treatment Axis |
| title_full | The Role of the Microbiome in Oral Squamous Cell Carcinoma with Insight into the Microbiome–Treatment Axis |
| title_fullStr | The Role of the Microbiome in Oral Squamous Cell Carcinoma with Insight into the Microbiome–Treatment Axis |
| title_full_unstemmed | The Role of the Microbiome in Oral Squamous Cell Carcinoma with Insight into the Microbiome–Treatment Axis |
| title_short | The Role of the Microbiome in Oral Squamous Cell Carcinoma with Insight into the Microbiome–Treatment Axis |
| title_sort | role of the microbiome in oral squamous cell carcinoma with insight into the microbiome treatment axis |
| topic | oral microbiome gut microbiome oral squamous cell carcinoma head and neck cancer microbial |
| url | https://www.mdpi.com/1422-0067/21/21/8061 |
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