Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection
Chromatin dynamics is thought to play an important role in the maintenance of telomeres, yet how has remained poorly understood. Here the authors locally enrich heterochromatin protein 1α (HP1α) at human telomeres to provide insights into the crosstalk between epigenetic regulations and structural d...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05840-y |
| _version_ | 1828972012654034944 |
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| author | Tracy T. Chow Xiaoyu Shi Jen-Hsuan Wei Juan Guan Guido Stadler Bo Huang Elizabeth H. Blackburn |
| author_facet | Tracy T. Chow Xiaoyu Shi Jen-Hsuan Wei Juan Guan Guido Stadler Bo Huang Elizabeth H. Blackburn |
| author_sort | Tracy T. Chow |
| collection | DOAJ |
| description | Chromatin dynamics is thought to play an important role in the maintenance of telomeres, yet how has remained poorly understood. Here the authors locally enrich heterochromatin protein 1α (HP1α) at human telomeres to provide insights into the crosstalk between epigenetic regulations and structural dynamics at the telomeres. |
| first_indexed | 2024-12-14T13:19:43Z |
| format | Article |
| id | doaj.art-fba23e2f45694006b4935b2e453fa373 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:19:43Z |
| publishDate | 2018-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-fba23e2f45694006b4935b2e453fa3732022-12-21T22:59:58ZengNature PortfolioNature Communications2041-17232018-09-019111310.1038/s41467-018-05840-yLocal enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protectionTracy T. Chow0Xiaoyu Shi1Jen-Hsuan Wei2Juan Guan3Guido Stadler4Bo Huang5Elizabeth H. Blackburn6Department of Biochemistry and Biophysics, University of California, San FranciscoDepartment of Pharmaceutical Chemistry, University of California, San FranciscoDepartment of Biochemistry and Biophysics, University of California, San FranciscoDepartment of Pharmaceutical Chemistry, University of California, San FranciscoBerkeley Lights IncDepartment of Pharmaceutical Chemistry, University of California, San FranciscoDepartment of Biochemistry and Biophysics, University of California, San FranciscoChromatin dynamics is thought to play an important role in the maintenance of telomeres, yet how has remained poorly understood. Here the authors locally enrich heterochromatin protein 1α (HP1α) at human telomeres to provide insights into the crosstalk between epigenetic regulations and structural dynamics at the telomeres.https://doi.org/10.1038/s41467-018-05840-y |
| spellingShingle | Tracy T. Chow Xiaoyu Shi Jen-Hsuan Wei Juan Guan Guido Stadler Bo Huang Elizabeth H. Blackburn Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection Nature Communications |
| title | Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection |
| title_full | Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection |
| title_fullStr | Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection |
| title_full_unstemmed | Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection |
| title_short | Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection |
| title_sort | local enrichment of hp1alpha at telomeres alters their structure and regulation of telomere protection |
| url | https://doi.org/10.1038/s41467-018-05840-y |
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