Peripheral blood monocyte count and outcomes in patients with interstitial lung disease: a systematic review and meta-analysis
Background Peripheral blood monocyte counts have been associated with poor outcomes in interstitial lung disease (ILD). However, studies are limited by variable biomarker thresholds, analytic approaches and heterogenous populations. This systematic review and meta-analysis characterised the relation...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2023-09-01
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| Series: | European Respiratory Review |
| Online Access: | http://err.ersjournals.com/content/32/169/230072.full |
| _version_ | 1827800052305756160 |
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| author | Bohyung Min Amanda Grant-Orser Kerri A. Johannson |
| author_facet | Bohyung Min Amanda Grant-Orser Kerri A. Johannson |
| author_sort | Bohyung Min |
| collection | DOAJ |
| description | Background
Peripheral blood monocyte counts have been associated with poor outcomes in interstitial lung disease (ILD). However, studies are limited by variable biomarker thresholds, analytic approaches and heterogenous populations. This systematic review and meta-analysis characterised the relationship between monocytes and clinical outcomes in ILD.
Methods
Electronic database searches were performed. Two reviewers screened abstracts and extracted data. Pooled estimates (hazard ratios (HRs)) of monocyte count thresholds were calculated for their association with mortality using ≥0.6×109 and >0.9×109 cells·L−1 for unadjusted models and ≥0.95×109 cells·L−1 for adjusted models, using random effects, with heterogeneity and bias assessed. Disease progression associated with monocytes >0.9×109cells·L−1 was also calculated.
Results
Of 3279 abstracts, 13 were included in the systematic review and eight in the meta-analysis. The pooled unadjusted HR for mortality for monocyte counts ≥0.6×109 cells·L−1 was 1.71 (95% CI 1.34–2.19, p<0.001, I2=0%) and for monocyte counts >0.90×109 cells·L−1 it was 2.44 (95% CI 1.53–3.87, p=0.0002, I2=52%). The pooled adjusted HR for mortality for monocyte counts ≥0.95×109 cells·L−1 was 1.93 (95% CI 1.24–3.01, p=0.0038 I2=69%). The pooled HR for disease progression associated with increased monocyte counts was 1.83 (95% CI 1.40–2.39, p<0.0001, I2=28%).
Conclusions
Peripheral blood monocyte counts were associated with an increased risk of mortality and disease progression in patients with ILD. |
| first_indexed | 2024-03-11T20:01:00Z |
| format | Article |
| id | doaj.art-fba31e4e71e747c5b09c2d3522926f46 |
| institution | Directory Open Access Journal |
| issn | 0905-9180 1600-0617 |
| language | English |
| last_indexed | 2024-03-11T20:01:00Z |
| publishDate | 2023-09-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | European Respiratory Review |
| spelling | doaj.art-fba31e4e71e747c5b09c2d3522926f462023-10-04T08:29:29ZengEuropean Respiratory SocietyEuropean Respiratory Review0905-91801600-06172023-09-013216910.1183/16000617.0072-20230072-2023Peripheral blood monocyte count and outcomes in patients with interstitial lung disease: a systematic review and meta-analysisBohyung Min0Amanda Grant-Orser1Kerri A. Johannson2 Department of Medicine, Division of Respirology, University of Calgary, Calgary, AB, Canada Department of Medicine, Division of Respirology, University of Calgary, Calgary, AB, Canada Department of Medicine, Division of Respirology, University of Calgary, Calgary, AB, Canada Background Peripheral blood monocyte counts have been associated with poor outcomes in interstitial lung disease (ILD). However, studies are limited by variable biomarker thresholds, analytic approaches and heterogenous populations. This systematic review and meta-analysis characterised the relationship between monocytes and clinical outcomes in ILD. Methods Electronic database searches were performed. Two reviewers screened abstracts and extracted data. Pooled estimates (hazard ratios (HRs)) of monocyte count thresholds were calculated for their association with mortality using ≥0.6×109 and >0.9×109 cells·L−1 for unadjusted models and ≥0.95×109 cells·L−1 for adjusted models, using random effects, with heterogeneity and bias assessed. Disease progression associated with monocytes >0.9×109cells·L−1 was also calculated. Results Of 3279 abstracts, 13 were included in the systematic review and eight in the meta-analysis. The pooled unadjusted HR for mortality for monocyte counts ≥0.6×109 cells·L−1 was 1.71 (95% CI 1.34–2.19, p<0.001, I2=0%) and for monocyte counts >0.90×109 cells·L−1 it was 2.44 (95% CI 1.53–3.87, p=0.0002, I2=52%). The pooled adjusted HR for mortality for monocyte counts ≥0.95×109 cells·L−1 was 1.93 (95% CI 1.24–3.01, p=0.0038 I2=69%). The pooled HR for disease progression associated with increased monocyte counts was 1.83 (95% CI 1.40–2.39, p<0.0001, I2=28%). Conclusions Peripheral blood monocyte counts were associated with an increased risk of mortality and disease progression in patients with ILD.http://err.ersjournals.com/content/32/169/230072.full |
| spellingShingle | Bohyung Min Amanda Grant-Orser Kerri A. Johannson Peripheral blood monocyte count and outcomes in patients with interstitial lung disease: a systematic review and meta-analysis European Respiratory Review |
| title | Peripheral blood monocyte count and outcomes in patients with interstitial lung disease: a systematic review and meta-analysis |
| title_full | Peripheral blood monocyte count and outcomes in patients with interstitial lung disease: a systematic review and meta-analysis |
| title_fullStr | Peripheral blood monocyte count and outcomes in patients with interstitial lung disease: a systematic review and meta-analysis |
| title_full_unstemmed | Peripheral blood monocyte count and outcomes in patients with interstitial lung disease: a systematic review and meta-analysis |
| title_short | Peripheral blood monocyte count and outcomes in patients with interstitial lung disease: a systematic review and meta-analysis |
| title_sort | peripheral blood monocyte count and outcomes in patients with interstitial lung disease a systematic review and meta analysis |
| url | http://err.ersjournals.com/content/32/169/230072.full |
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