Inhibition of NPC1L1 disrupts adaptive responses of drug‐tolerant persister cells to chemotherapy

Inhibition of NPC1L1 disrupts adaptive responses of drug‐tolerant persister cells to chemotherapy

Abstract Entering a drug‐tolerant persister (DTP) state of cancer cells is a transient self‐adaptive mechanism by which a residual cell subpopulation accelerates tumor progression. Here, we identified the acquisition of a DTP phenotype in multidrug‐resistant (MDR) cancer cells as a tolerance respons...

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Main Authors: Zhe Zhang, Siyuan Qin, Yan Chen, Li Zhou, Mei Yang, Yongquan Tang, Jing Zuo, Jian Zhang, Atsushi Mizokami, Edouard C Nice, Hai‐Ning Chen, Canhua Huang, Xiawei Wei
Format: Article
Language:English
Published: Springer Nature 2022-01-01
Series:EMBO Molecular Medicine
Subjects:
cancer therapy
drug‐tolerant persister state
multidrug resistance
NPC1L1
oxidative stress
Online Access:https://doi.org/10.15252/emmm.202114903

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