Rare variant burden analysis from exomes of three consanguineous families reveals LILRB1 and PRSS3 as potential key proteins in inflammatory bowel disease pathogenesis

Rare variant burden analysis from exomes of three consanguineous families reveals LILRB1 and PRSS3 as potential key proteins in inflammatory bowel disease pathogenesis

BackgroundInflammatory bowel disease (IBD) is a chronic autoimmune disorder characterized by severe inflammation and mucosal destruction of the intestine. The specific, complex molecular processes underlying IBD pathogenesis are not well understood. Therefore, this study is aimed at identifying and...

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Bibliographic Details
Main Authors: Rana Mohammed Jan, Huda Husain Al-Numan, Nada Hassan Al-Twaty, Nuha Alrayes, Hadeel A. Alsufyani, Meshari A. Alaifan, Bakr H. Alhussaini, Noor Ahmad Shaik, Zuhier Awan, Yousef Qari, Omar I. Saadah, Babajan Banaganapalli, Mahmoud Hisham Mosli, Ramu Elango
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Medicine
Subjects:
inflammatory bowel disease
missense mutation
Crohn’s disease
gastrointestinal tract
protein modeling
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1164305/full

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