Multi-fractal modeling of curcumin release mechanism from polymeric nanomicelles
The physicochemical properties of “smart” or stimuli-sensitive amphiphilic copolymers can be modeled as a function of their environment. In special, pH-sensitive copolymers have practical applications in the biomedical field as drug delivery systems. Interactions between the structural units of any...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Drug Delivery |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/10717544.2022.2118402 |
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| author | Camelia E. Iurciuc (Tincu) Marcel Popa Leonard I. Atanase Ovidiu Popa Lacramioara Ochiuz Paraschiva Postolache Vlad Ghizdovat Stefan A. Irimiciuc Maricel Agop Constantin Volovat Simona Volovat |
| author_facet | Camelia E. Iurciuc (Tincu) Marcel Popa Leonard I. Atanase Ovidiu Popa Lacramioara Ochiuz Paraschiva Postolache Vlad Ghizdovat Stefan A. Irimiciuc Maricel Agop Constantin Volovat Simona Volovat |
| author_sort | Camelia E. Iurciuc (Tincu) |
| collection | DOAJ |
| description | The physicochemical properties of “smart” or stimuli-sensitive amphiphilic copolymers can be modeled as a function of their environment. In special, pH-sensitive copolymers have practical applications in the biomedical field as drug delivery systems. Interactions between the structural units of any polymer-drug system imply mutual constraints at various scale resolutions and the nonlinearity is accepted as one of the most fundamental properties. The release kinetics, as a function of pH, of a model active principle, i.e., Curcumin, from nanomicelles obtained from amphiphilic pH-sensitive poly(2-vinylpyridine)-b-poly(ethylene oxide) (P2VP-b-PEO) tailor-made diblock copolymers was firstly studied by using the Rietger-Peppas equation. The value of the exponential coefficient, n, is around 0.5, generally suggesting a diffusion process, slightly disturbed in some cases. Moreover, the evaluation of the polymer-drug system’s nonstationary dynamics was caried out through harmonic mapping from the usual space to the hyperbolic one. The kinetic model we developed, based on fractal theory, fits very well with the experimental data obtained for the release of Curcumin from the amphiphilic copolymer micelles in which it was encapsulated. This model is a variant of the classical kinetic models based on the formal kinetics of the process. |
| first_indexed | 2024-04-14T00:15:41Z |
| format | Article |
| id | doaj.art-fba5e529b59f49c69bf40b62f8c00816 |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-04-14T00:15:41Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-fba5e529b59f49c69bf40b62f8c008162022-12-22T02:23:08ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642022-12-012912883289610.1080/10717544.2022.2118402Multi-fractal modeling of curcumin release mechanism from polymeric nanomicellesCamelia E. Iurciuc (Tincu)0Marcel Popa1Leonard I. Atanase2Ovidiu Popa3Lacramioara Ochiuz4Paraschiva Postolache5Vlad Ghizdovat6Stefan A. Irimiciuc7Maricel Agop8Constantin Volovat9Simona Volovat10Department of Pharmaceutical Technology, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, RomaniaDepartment of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Protection of the Environment, Gheorghe Asachi” Technical University, Iaşi, RomaniaAcademy of Romanian Scientists, Bucharest, RomaniaDepartment of Emergency Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, RomaniaDepartment of Pharmaceutical and Biotechnological Drug Industry, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania1st Medical Department, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, RomaniaDepartment of Biophysics and Medical Physics, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Iasi, RomaniaNational Institute for Laser, Plasma and Radiation Physics, Bucharest, RomaniaAcademy of Romanian Scientists, Bucharest, RomaniaDepartment of Medical Oncology Radiotherapy, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Iasi, RomaniaDepartment of Medical Oncology Radiotherapy, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Iasi, RomaniaThe physicochemical properties of “smart” or stimuli-sensitive amphiphilic copolymers can be modeled as a function of their environment. In special, pH-sensitive copolymers have practical applications in the biomedical field as drug delivery systems. Interactions between the structural units of any polymer-drug system imply mutual constraints at various scale resolutions and the nonlinearity is accepted as one of the most fundamental properties. The release kinetics, as a function of pH, of a model active principle, i.e., Curcumin, from nanomicelles obtained from amphiphilic pH-sensitive poly(2-vinylpyridine)-b-poly(ethylene oxide) (P2VP-b-PEO) tailor-made diblock copolymers was firstly studied by using the Rietger-Peppas equation. The value of the exponential coefficient, n, is around 0.5, generally suggesting a diffusion process, slightly disturbed in some cases. Moreover, the evaluation of the polymer-drug system’s nonstationary dynamics was caried out through harmonic mapping from the usual space to the hyperbolic one. The kinetic model we developed, based on fractal theory, fits very well with the experimental data obtained for the release of Curcumin from the amphiphilic copolymer micelles in which it was encapsulated. This model is a variant of the classical kinetic models based on the formal kinetics of the process.https://www.tandfonline.com/doi/10.1080/10717544.2022.2118402amphiphilic copolymersmicellesdrug release kineticsfractal model |
| spellingShingle | Camelia E. Iurciuc (Tincu) Marcel Popa Leonard I. Atanase Ovidiu Popa Lacramioara Ochiuz Paraschiva Postolache Vlad Ghizdovat Stefan A. Irimiciuc Maricel Agop Constantin Volovat Simona Volovat Multi-fractal modeling of curcumin release mechanism from polymeric nanomicelles Drug Delivery amphiphilic copolymers micelles drug release kinetics fractal model |
| title | Multi-fractal modeling of curcumin release mechanism from polymeric nanomicelles |
| title_full | Multi-fractal modeling of curcumin release mechanism from polymeric nanomicelles |
| title_fullStr | Multi-fractal modeling of curcumin release mechanism from polymeric nanomicelles |
| title_full_unstemmed | Multi-fractal modeling of curcumin release mechanism from polymeric nanomicelles |
| title_short | Multi-fractal modeling of curcumin release mechanism from polymeric nanomicelles |
| title_sort | multi fractal modeling of curcumin release mechanism from polymeric nanomicelles |
| topic | amphiphilic copolymers micelles drug release kinetics fractal model |
| url | https://www.tandfonline.com/doi/10.1080/10717544.2022.2118402 |
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