Netrin-1 Reduces Monocyte and Macrophage Chemotaxis towards the Complement Component C5a.

Netrin-1 Reduces Monocyte and Macrophage Chemotaxis towards the Complement Component C5a.

Netrin-1, acting at its cognate receptor UNC5b, has been previously demonstrated to inhibit CC chemokine-induced immune cell migration. In line with this, we found that netrin-1 was able to inhibit CCL2-induced migration of bone marrow derived macrophages (BMDMs). However, whether netrin-1 is capabl...

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Bibliographic Details
Main Authors: Lewis Taylor, Maximillian Hugo Brodermann, David McCaffary, Asif Jilani Iqbal, David R Greaves
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4980032?pdf=render

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