Targeting RNA:protein interactions with an integrative approach leads to the identification of potent YBX1 inhibitors

Targeting RNA:protein interactions with an integrative approach leads to the identification of potent YBX1 inhibitors

RNA-protein interactions (RPIs) are promising targets for developing new molecules of therapeutic interest. Nevertheless, challenges arise from the lack of methods and feedback between computational and experimental techniques during the drug discovery process. Here, we tackle these challenges by de...

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Bibliographic Details
Main Authors: Krystel El Hage, Nicolas Babault, Olek Maciejak, Bénédicte Desforges, Pierrick Craveur, Emilie Steiner, Juan Carlos Rengifo-Gonzalez, Hélène Henrie, Marie-Jeanne Clement, Vandana Joshi, Ahmed Bouhss, Liya Wang, Cyril Bauvais, David Pastré
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-01-01
Series:eLife
Subjects:
YBX1
RNA-binding proteins
small molecules
molecular dynamics
free energy simulations
microtubule bench
Online Access:https://elifesciences.org/articles/80387

Internet

https://elifesciences.org/articles/80387

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