Association between serum uric acid levels and clinical outcomes in patients with acute kidney injury
AbstractBackground The effects of serum uric acid (SUA) on clinical outcomes in patients with acute kidney injury (AKI) are unclear. The aim of this study was to investigate the association of SUA levels with clinical outcomes of AKI patients.Methods The data of AKI patients hospitalized in the Affi...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2169617 |
| _version_ | 1797658546482970624 |
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| author | Xunliang Li Jianping Sun Quandong Bu Bin Zhou Lin Li Xiaofei Man Long Zhao Yan Xu Hong Luan |
| author_facet | Xunliang Li Jianping Sun Quandong Bu Bin Zhou Lin Li Xiaofei Man Long Zhao Yan Xu Hong Luan |
| author_sort | Xunliang Li |
| collection | DOAJ |
| description | AbstractBackground The effects of serum uric acid (SUA) on clinical outcomes in patients with acute kidney injury (AKI) are unclear. The aim of this study was to investigate the association of SUA levels with clinical outcomes of AKI patients.Methods The data of AKI patients hospitalized in the Affiliated Hospital of Qingdao University were retrospectively reviewed. Multivariable logistic regression was utilized to assess the association between SUA levels and the clinical outcomes of AKI patients. Receiver operating characteristic (ROC) analysis was applied to assess the predictive ability of SUA levels for in-hospital mortality in patients with AKI.Results A total of 4,646 AKI patients were eligible for study inclusion. In multivariable analysis, after adjustment for various confounding factors in the fully adjusted model, a higher SUA level was found to be associated with increased in-hospital mortality of AKI patients with an odds ratio (OR) of 1.72 (95% CI, 1.21–2.33, p = 0.005) for the SUA level >5.1–6.9 mg/dl group and 2.75 (95% CI, 1.78–4.26, p < 0.001) for the SUA level >6.9 mg/dl group compared with the reference group (SUA ≤3.6 mg/dl). In the ROC analysis, the area under the curve (AUC) of SUA was 0.65 with a sensitivity of 51% and a specificity of 73%.Conclusions An elevated SUA level is associated with an increased risk of in-hospital mortality in patients with AKI, and it appears to be an independent prognostic marker for these patients. |
| first_indexed | 2024-03-11T18:00:37Z |
| format | Article |
| id | doaj.art-fba97aaf614c4c29aac5b5bbcdad80bb |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-03-11T18:00:37Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-fba97aaf614c4c29aac5b5bbcdad80bb2023-10-17T09:23:23ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492023-12-0145110.1080/0886022X.2023.2169617Association between serum uric acid levels and clinical outcomes in patients with acute kidney injuryXunliang Li0Jianping Sun1Quandong Bu2Bin Zhou3Lin Li4Xiaofei Man5Long Zhao6Yan Xu7Hong Luan8Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaAbstractBackground The effects of serum uric acid (SUA) on clinical outcomes in patients with acute kidney injury (AKI) are unclear. The aim of this study was to investigate the association of SUA levels with clinical outcomes of AKI patients.Methods The data of AKI patients hospitalized in the Affiliated Hospital of Qingdao University were retrospectively reviewed. Multivariable logistic regression was utilized to assess the association between SUA levels and the clinical outcomes of AKI patients. Receiver operating characteristic (ROC) analysis was applied to assess the predictive ability of SUA levels for in-hospital mortality in patients with AKI.Results A total of 4,646 AKI patients were eligible for study inclusion. In multivariable analysis, after adjustment for various confounding factors in the fully adjusted model, a higher SUA level was found to be associated with increased in-hospital mortality of AKI patients with an odds ratio (OR) of 1.72 (95% CI, 1.21–2.33, p = 0.005) for the SUA level >5.1–6.9 mg/dl group and 2.75 (95% CI, 1.78–4.26, p < 0.001) for the SUA level >6.9 mg/dl group compared with the reference group (SUA ≤3.6 mg/dl). In the ROC analysis, the area under the curve (AUC) of SUA was 0.65 with a sensitivity of 51% and a specificity of 73%.Conclusions An elevated SUA level is associated with an increased risk of in-hospital mortality in patients with AKI, and it appears to be an independent prognostic marker for these patients.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2169617Acute kidney injuryserum uric acidmortalityprognostic |
| spellingShingle | Xunliang Li Jianping Sun Quandong Bu Bin Zhou Lin Li Xiaofei Man Long Zhao Yan Xu Hong Luan Association between serum uric acid levels and clinical outcomes in patients with acute kidney injury Renal Failure Acute kidney injury serum uric acid mortality prognostic |
| title | Association between serum uric acid levels and clinical outcomes in patients with acute kidney injury |
| title_full | Association between serum uric acid levels and clinical outcomes in patients with acute kidney injury |
| title_fullStr | Association between serum uric acid levels and clinical outcomes in patients with acute kidney injury |
| title_full_unstemmed | Association between serum uric acid levels and clinical outcomes in patients with acute kidney injury |
| title_short | Association between serum uric acid levels and clinical outcomes in patients with acute kidney injury |
| title_sort | association between serum uric acid levels and clinical outcomes in patients with acute kidney injury |
| topic | Acute kidney injury serum uric acid mortality prognostic |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2169617 |
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